Clinical trials: GI Disorders
Esophageal Neoplasms
Barrett's Esophagus and Esophageal Adenocarcinoma, Searching for Reliable Diagnostic RNA Plasma-based Biomarkers
This study is designed to perform a explorative search of the transcriptome to detect new circulating diagnostic sensitive and specific biomarkers in patients with Barrett's esophagus or esophageal adenocarcinoma.
- Trial name
- NCT05688176
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cervical Cancer, Breast Cancer
Using Effective Provider-Patient Communication to Improve Cancer Screening Among Low Literacy Patients
What's the purpose of this study? This 4-year study is designed: (1) to teach primary care physicians how to recognize low health literacy patients and effectively counsel them on cancer screening using risk communication and…
- Conditions
- Cervical Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT01361035
- Testing
- Cancer risk communication skills training
- Where
- 5 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Medicine
Liver Cirrhoses, Chronic Pancreatitis
Malnutrition in Chronic Gastrointestinal Diseases, Cross-sectional Study
Malnutrition and muscle wasting are common consequences of life-threatening, chronic diseases of the gastrointestinal tract. Such diseases include liver cirrhosis, chronic pancreatitis and short bowel syndrome.
- Conditions
- Liver Cirrhoses, Chronic Pancreatitis, Short Bowel Syndrome
- Trial name
- NCT04474743
- Testing
- No intervention - cross-sectional observational only
- Where
- 3 sites in Germany
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Gastric Cancer, Colorectal Cancer
Evaluation of Fecal Multi-target Biomarkers in the Screening of Digestive Tract Cancers
This study is a multi-center, observational study. Participants scheduled for gastroscopy and colonoscopy will undergo an epidemiological assessment and provide a stool sample prior to endoscopy for qualitative Fecal…
- Trial name
- NCT07600125
- Testing
- Qualitative Fecal Immunochemical Test (FIT), quantitative (FIT), and testing for new biomarkers
- Where
- 13 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Colorectal Cancer
Prevention and Early Detection Biomarkers of Adenomas and CRC Lesions During CRC Screening
The investigators designed a prospective study to evaluate the predictive ability of detection of mutations in genes involved in carcinogenesis of the colon (eg hMLH1, K-Ras, B-Raf, ccfDNA) in a sample of Greek population…
- Trial name
- NCT02596113
- Where
- Greece
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
Colorectal Cancer
Colon Cancer Screening in First-Degree Relatives of Hispanic Colorectal Cancer (CRC) Patients
Primary Objectives: 1. To evaluate knowledge, beliefs, attitudes and values that influence perceptions and utilization of colorectal cancer screening (CRCS) among first-degree relatives of Hispanic CRC patients. 2.
- Trial name
- NCT00838318
- Testing
- Interview
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer, Esophageal Cancer
PAN-study: Pan-Cancer Early Detection Study (PAN)
The PAN-cancer Early Detection study or PAN-study is a prospective cross-sectional observational case-control study evaluating whether Breath Biopsy can differentiate between patients with and without different cancer types by…
- Conditions
- Gastric Cancer, Esophageal Cancer, Liver Cancer
- Trial name
- NCT03756597
- Testing
- ReCIVA, CASPER
- Where
- United Kingdom
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Owlstone Ltd
Stress, Psychological, Sleep
Mindfulness, Emotional Well-being, and Sleep Quality
The purpose of this study is to determine whether participating in a Mindfulness-Based Stress Reduction (MBSR) program increases mindful attention and awareness, and whether anticipated changes in mindfulness relate to improved…
- Trial name
- NCT00887614
- Testing
- Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Duke University
Gastric Carcinoma Stage IV, Esophagogastric Junction Adenocarcinoma Stage IV
FOLFOX6 Versus mFOLFIRINOX as First Line Chemotherapy in Metastatic Gastric Cancer or Esophagogastric Junction Adenocarcinoma (Type II-III)
Patients with metastatic adenocarcinoma of the stomach or the esophagogastric junction (II-III type by Siewert) without previous therapy will be treated with one of two chemotherapy combinations .
- Trial name
- IRIGA (NCT04442984)
- Testing
- Irinotecan, Oxaliplatin, 5-FU
- Where
- Russia
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Blokhin's Russian Cancer Research Center
Residents of Palau Aged 18 Years or Older
Prevalence of Helicobacter Pylori Infection
1. To investigate the prevalence of Helicobacter pylori infection among adults in Palau using stool antigen testing. 2. To analyze the correlation between H.
- Trial name
- NCT07840833
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Stage IV Gastrointestinal Cancer, Advanced Gynecological Cancer
The Mediating Effects of Decentering on Self-Management of Stress and End of Life Planning
Caregivers of persons with cancer may face many challenges as they support and care for a person receiving treatment. Sometimes having to help make treatment decisions for a patient can cause distress for caregivers.
- Trial name
- NCT02842047
- Testing
- Stop, Breathe & Think™, End of Life Planning Videos, Caregiver wellness videos
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Fibromyalgia, Irritable Bowel Syndrome
Fecal Calprotectin Levels in Patients With Fibromyalgia
This study was designed to evaluate fecal calprotectin levels in patients with fibromyalgia syndrome. Fecal calprotectin levels from fibromyalgia patients with and without gastrointestinal symptoms as well as healthy controls…
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Abdominal Pain
- Trial name
- NCT05404893
- Testing
- Fecal calprotectin measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
GERD
A Study to Evaluate the PK, PD and Safety of CKD-382 in Healthy Subjects
to evaluate the pharmacokinetics, pharmacodynamics and safety after single/multiple administration of CKD-382, D860 and D027 in healthy subjects
- Trial name
- NCT05108038
- Testing
- CKD-382, D860, D027
- Where
- South Korea
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Inflammatory Bowel Diseases
Phenotypic Characteristics of Inflammatory Bowel Disease in Southeast Asian Population - A Multi-centered US Study
This is a retrospective, case control study of inflammatory bowel disease. This study will analyze the phenotypic characteristics of inflammatory bowel disease in the Southeast Asian population and will help describe clinical…
- Trial name
- NCT00573846
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Ineffective Esophageal Motility, GERD (Gastroesophageal Reflux Disease)
The Influence of Specialized Food Products Based on Ice-Cream on Esophageal Motility
This study aims to assess the influence of specialized products based on ice cream on esophageal motility
- Trial name
- MICE (NCT07121803)
- Testing
- specialized food based on ice cream, order 1, specialized food based on ice cream, order 2, specialized food based on ice cream, order 3
- Where
- Russia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Scientific Institution
Colon Polyp, Colon Adenoma
Impact of Screen Size on Colorectal Adenoma Detection
The purpose of this study is to assess whether the use of large screen during colonoscopy will increase adenoma detection rate.
- Conditions
- Colon Polyp, Colon Adenoma, Colorectal Neoplasms
- Trial name
- NCT04749303
- Testing
- Large Screen
- Where
- Hong Kong
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Short Bowel Syndrome
MENDD Tolerance Assessment Study
This study will utilize approved devices in an off-label manner to create forces required to induce intestinal lengthening. Radial and longitudinal forces are both required, and two devices will be used to create forces in order…
- Trial name
- NCT06185088
- Testing
- Coda® Balloon Catheters, Double Balloon Endoscope (DBE)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Colon Cancer, Rectal Cancer
Pilot Study Evaluating the Efficacy of AlloMEM After Loop Ileostomy
The objective of this study is to investigate whether the use of Human Peritoneal Membrane (HPM) in a temporary loop ileostomy is beneficial to patients.
- Trial name
- AlloMem (NCT01113736)
- Testing
- AlloMEM™
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Type 1 Diabetes, Celiac Disease
General Population Level Estimation for Type 1 Diabetes Risk in Children During Routine Care Delivery
In partnership with Helmsley Charitable Trust, the Sanford PLEDGE Study is a large-scale, observational, feasibility study of general population screening for T1D and celiac autoantibodies.
- Trial name
- PLEDGE (NCT04477928)
- Testing
- Sera and whole blood sampling, Differential Gene Expression (DGE)
- Where
- 4 sites in United States
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Intestinal Disorder, Glucose Metabolism Disorders
Grain Fibre and Gut Health
Wholegrain fibre is known to affect on the gut health, but also may cause intestinal discomfort. Thus, many individuals may avoid the consumption of whole grain cereals in spite of their known health benefits, and may in this…
- Conditions
- Intestinal Disorder, Glucose Metabolism Disorders, Inflammation
- Trial name
- FIBREFECTS (NCT03550365)
- Testing
- Rye bran bread intervention, Rye bread intervention, Wheat bread diet
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
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