Clinical trials: Galectin 3
Periodontitis, Periodontal Diseases
Determination of Salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible Factor-1 Alpha (HIF-1α), E-cadherin, Galectin 3, IL-4, IL-10 and TNF-α Levels in Individuals With Different Degrees of Periodontal Disease
The aim of this clinical study is; Comparatively comparing salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible factor-1 alpha (HIF-1α), E-cadherin, galectin 3, IL-4, IL-10 and TNF-α levels in…
- Trial name
- NCT06430450
- Testing
- Clinical measurements and saliva samples collection
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Hepatic Impairment
A Single and Repeat Dose Trial in Participants With Hepatic Impairment
This study is a a single (open-label) and repeat dose (randomised, placebo controlled) trial to assess the safety, tolerability and pharmacokinetics of GB1211 (Gal-3 inhibitor) in participants with hepatic impairment (Child Pugh…
- Trial name
- NCT05009680
- Testing
- GB1211
- Where
- 4 sites in Bulgaria
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Galecto Biotech AB
Idiopathic Pulmonary Fibrosis
RCT (Randomized Control Trial) of TD139 vs Placebo in HV's (Human Volunteers) and IPF Patients
This study will be divided into 2 parts. Part 1 is a randomized, double-blind, single centre, placebo-controlled, single ascending dose (SAD) phase I study designed to assess the safety, tolerability, PK and PD (Pharmacodynamic)…
- Trial name
- NCT02257177
- Testing
- Inhaled TD139
- Where
- 5 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galecto Biotech AB
HIV Infections, Frailty
Sleep Quality and Frailty Among People Living With HIV
With effective antiretroviral therapy (ART), people living with HIV (PLWH) are living longer and are increasingly experiencing aging-related conditions such as frailty and sleep problems.
- Conditions
- HIV Infections, Frailty, Sleep Quality, Oral Frailty
- Trial name
- NCT07880054
- Testing
- No intervention (observational assessments)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- National Sun Yat-sen University
Galectin-3 During Respiratory Weaning
Galectin and Respiratory Weaning
Galectin-3 is a biomarker for fibrotic activity. In the course of invasive ventilation, fibrotic changes in the lungs may occur.
- Trial name
- Gal-3 (NCT05054556)
- Testing
- Labaratory tests
- Where
- 2 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Asklepios Neurological Clinic Bad Salzhausen
Galectin 3, Healthy Aging
G3P-01 in Volunteers With Elevated Galectin-3
G3P-01 is an investigational pectin extracted, enriched and purified from commercial squash puree intended for human consumption.
- Trial name
- Galaxy (NCT06398821)
- Testing
- G3P-01
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- General Practitioners Research Institute
Transthyretin Amyloidosis
New Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin Amyloidosis
The development of cardiac amyloidosis is caused by the deposition of misfolded, insoluble proteins in the extracellular matrix of tissues.
- Trial name
- NCT06345235
- Testing
- blood test
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- John Paul II Hospital, Krakow
Ailesel Akdeniz Ateşi
"Galectin-3 as a Marker of Subclinical Inflammation in FMF"
The goal of this observational study is to learn about the relationship between serum Galectin-3 levels and subclinical inflammation in patients with Familial Mediterranean Fever (FMF).
- Trial name
- NCT06451471
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Turkish League Against Rheumatism
Galectin-3 and Pemphigus
Evaluation of Galectin-3 in Serum and Saliva of Pemphigus Patients
Assessment of the expression of galectin-3 in serum and saliva of pemphigus patients and compare it with age and sex matched controls.
- Trial name
- NCT05992727
- Testing
- Galectin 3 measurement in serum and saliva by ELIZA
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Gingivitis, Periodontitis
Galectin Role in Periodontal Disease
This study aimed at exploring the effect of nonsurgical periodontal treatment on galectin 1 and 3 GCF levels in patients having gingivitis, periodontitis stage III compared to periodontally healthy individuals and if galectin-1…
- Trial name
- NCT06038812
- Testing
- GCF sample collection, non-surgical periodontal treatment
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Periodontal Diseases
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
- Trial name
- NCT05281796
- Testing
- GCF obtaining, saliva obtaining
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endometriosis
Galectin-3 in Patients With Endometriosis
The exact cause of endometriosis is unknown ,so our study is to investigate the relationship between Galectin-3 and endometriosis by comparing between its level in healthy and endometriosis women.
- Trial name
- NCT03212612
- Testing
- samples obtained by laparoscopy or punch biopsy for analysis by ELISA
- Where
- 3 sites in Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
ST Elevation Myocardial Infarction, HF - Heart Failure
Diagnostic Values of Galectin-3, Soluble ST2 and BNP in Predicting the Clinical Outcome of ST-Segment Elevation Myocardial Infarction Patients
An acute ST-elevation myocardial infarction occurs due to occlusion of one or more coronary arteries, causing transmural myocardial ischemia which in turn results in myocardial injury or necrosis.
- Conditions
- ST Elevation Myocardial Infarction, HF - Heart Failure, Stable Angina
- Trial name
- NCT05246215
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spinal Anesthesia
Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery
Ropivacaine is one of commonly used anesthetics for spinal anesthesia. Usually L2-3 or L3-4 intervertebral space is chosen for spinal anesthesia.
- Trial name
- NCT02565303
- Testing
- Intervertebral space, Ropivacaine
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 6th People's Hospital
Human Papillomavirus Infection
Serum Galectin-3 as a Marker of Human Papillomavirus Infection
This study aimed to assess the serum Galectin-3 levels in patients with warts both before and after cryotherapy and to investigate its potential contribution to the pathogenesis of human papillomavirus infection.
- Trial name
- NCT06005389
- Testing
- cryotherapy, serum Galectin-3 assay
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Periodontal Diseases
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases
Objectives: The aim of this study is; detection of peptidyl arginine deiminase4 (PAD4), galectin-3 and tumor necrosis factor alpha (TNF-α) levels in gingival crevicular fluid (GCF) samples of periodontally healthy, gingivitis and…
- Trial name
- NCT04777487
- Testing
- GCF obtaining
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Placenta Accreta, Third Trimester
A Serum Galectin-3 Levels in Placenta Accreta Spectrum Pregnancies
Placenta Accreta Spectrum (PAS) represents a significant cause of maternal morbidity and mortality, causing complications that surpass those posed by most routine obstetric issues.
- Trial name
- NCT05945446
- Testing
- Galectin 3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Periodontitis, Periodontal Inflammation
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.
This study aims to evaluate gingival crevicular fluid Galectin-3 and Interleukin-1beta levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in…
- Trial name
- NCT05449093
- Testing
- Periodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Sedentary Lifestyle, Cardiometabolic Risk
Effects of Aerobic and Resistance Exercise on Cardiovascular Biomarkers in Sedentary Women
This randomized controlled trial investigated the effects of aerobic and resistance exercise on cardiovascular and inflammatory biomarkers in sedentary young women.
- Trial name
- NCT07457047
- Testing
- Aerobic Exercise Training, Resistance Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Ankylosing Spondylitis
Galectin-3 Level in Ankylosing Spondylitis Patients
Forty-five AS patients and 35 healthy controls were enrolled in this study. Patients diagnosed with AS according to Modified New York criteria were included in the study.
- Trial name
- NCT04746196
- Testing
- Serum galectin-3 concentration was measured.
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital