Clinical trials: Gastrointestinal Bleed
Bleeding After GI Endoscopy
Endoscopic Application of Hemostatic Drug Powder in Lower Gastrointestinal Bleeding: A Pilot Study
This clinical trial will enroll patients at National Cheng Kung University Hospital. All patients who are hospitalized for lower gastrointestinal bleeding and undergo colonoscopy will be invited to participate.
- Trial name
- NCT07679139
- Testing
- Tranexamic acid and sucralfate powder spray, Standard endsocopic hemostasis
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Peptic Ulcer Hemorrhage
The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers
The purpose of this prospective study is to identify risk factors which could predict poor fading of SRH or early recurrent bleeding of peptic ulcer hemorrhage after successful endoscopic hemostasis and high-dose PPI infusion.
- Trial name
- CSE (NCT02197039)
- Testing
- esomeprazole or pantoprazole, Endoscopic hemostasis
- Where
- Taiwan
- Volunteers
- 316 people
- Sponsor
- National Cheng-Kung University Hospital
Portal Hypertension, Cirrhosis
The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed
Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies.
- Conditions
- Portal Hypertension, Cirrhosis, Hematemesis, Melena
- Trial name
- NCT00534677
- Testing
- Terlipressin, Octreotide
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- Aga Khan University
Peptic Ulcer Hemorrhage
Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common emergency for patients who need therapeutic endoscopy. According to international guidelines and Taiwan consensus, the standard therapy included proton pump inhibitor (PPI) and endoscopic…
- Trial name
- NCT05248321
- Testing
- Tranexamic Acid Powder
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -Healthy Volunteers Study
The objective of the investigation is to evaluate the feasibility of detecting blood in healthy volunteers after ingestion of autologous blood mixed with water.
- Trial name
- NCT05631652
- Testing
- PillSense System
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- EnteraSense Limited
Gastric Varices
Secondary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal rebleeding and improvement in survival.
- Trial name
- NCT02468206
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 64 people
- Sponsor
- West China Hospital
Esophageal Varices
Beta Blockers Versus Variceal Band Ligation and Beta Blockers for Primary Prophylaxis of Variceal Bleeding
Patients with scarring of the liver (cirrhosis) and portal hypertension (elevated blood pressure in the liver vasculature) can develop esophageal varices (dilated veins). These have an increased risk of bleeding each year.
- Trial name
- NCT00409084
- Testing
- endoscopic variceal band ligation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Virginia Commonwealth University
Von Willebrand Diseases
Prognostic Value of Implementing VCE on Top in Constitutional VWD-patients With GI-bleeding
Inclusion criteria: Only constitutional VWD-patients fulfilling the inclusion criteria of the French reference center for VWD will be included. Patients with acquired von Willebrand syndrome will not be included.
- Trial name
- NCT04466878
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Upper GI Bleeding
Clinical Risk Scores in Prediction Outcome of Acute UGIT Bleeding in Non Cirrhotic Patients
To compare the ability of 4 bleeding risk scoring systems (Glasgow -Blatchford score, MAP, H3B2 and ABC scores ) in prediction of: Need of intervention, Re bleeding, Thirty-day mortality, length of hospital stay
- Trial name
- NCT06254352
- Testing
- scoring system
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gastrointestinal Hemorrhage, Crohn Disease
Prucalopride Prior to Small Bowel Capsule Endoscopy
Small bowel capsule endoscopy is a test used to investigate for any abnormalities in the small bowel. The small bowel is about 4 meters long. The battery time of the capsule is about 8 hours.
- Conditions
- Gastrointestinal Hemorrhage, Crohn Disease, Celiac Disease, Intestinal Diseases
- Trial name
- NCT02806206
- Testing
- Prucalopride
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- University of British Columbia
Acute Bleeding Esophageal Varices, Liver Cirrhosis
Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding
Study hypothesis: Hepatic venous pressure gradient (HVPG)-directed primary prophylaxis with nonselective beta-blocker therapy (NSBB) leads to a reduction in first variceal bleeding episodes and is cost-effective in the long term.
- Trial name
- Porthos (NCT01618890)
- Testing
- Hepatic venous pressure gradient measurement
- Where
- 6 sites in Belgium, Netherlands
- Volunteers
- 78 people
- Sponsor
- Leiden University Medical Center
Intraventricular Hemorrhage, Sepsis
Placental Transfusion Project for Preterm Infants
The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants.
- Conditions
- Intraventricular Hemorrhage, Sepsis, Necrotizing Enterocolitis
- Trial name
- NCT02400697
- Testing
- <30 wks gestation or 1500 grams
- Where
- United States
- Volunteers
- 2,856 people
- Sponsor
- Indiana University
Portal Hypertension, Bleeding Gastric Varices
TIPS in Fundal Variceal Bleeding (the TFB Study)
In the last years, important advances have been done in the treatment and prevention of fundal variceal bleeding in patients with cirrhosis.
- Trial name
- TFB (NCT02364297)
- Testing
- Early TIPS
- Where
- 5 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigacions Biomèdiques August Pi i Sunyer
GastroIntestinal Bleeding
Analysis of Blood Metabolomics to Identify Potential Biomarkers of Gastrointestinal Bleeding
Despite advances in gastrointestinal endoscopy and pharmaceuticals, gastrointestinal bleeding is still a significant emergency disease with a high mortality rate of 1.9-5 per 100 people due to excessive bleeding and shock.
- Trial name
- NCT05547360
- Where
- Singapore
- Volunteers
- 32 people
- Sponsor
- National University of Singapore
Bleed Ulcer
Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding: A Randomized Controlled Trial
Background and Aim: Gastrointestinal bleeding (GIB) is a common problem in the hospital. GIB can be divided into upper GIB, small bowel bleeding, and lower GIB.
- Trial name
- NCT06421389
- Testing
- Tranexamic Acid Powder
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Peptic Ulcer, Bleeding
TAE and Surgery in Patients With Peptic Ulcer Bleeding Uncontrolled by Endoscopic Therapy
The aim of the study is to compare the outcomes of trans-catheter arterial embolization (TAE) and surgery as salvage therapy of peptic ulcer bleeding after failed endoscopic therapy.
- Trial name
- NCT00766961
- Testing
- Trans-catheter arterial embolization, Surgery
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Chinese University of Hong Kong
Gastric Cancer, Pancreatic Cancer
Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery
Primary objective of the study is to compare requirement of blood transfusion and mortality in patients receiving Tranexamic acid (Cyklokapron®) and those not receiving it.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Hepatocellular Cancer, Colon Cancer
- Trial name
- TMGS (NCT01655641)
- Testing
- Tranexamic acid, Standard of care
- Where
- Nepal
- Volunteers
- 118 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Esophageal Varices
Preventing Recurrent Bleeding After Eradication of Esophageal Varices
Esophageal variceal bleeding is a severe complication of portal hypertension. Banding ligation plus non-selective beta-blockers is the current recommendation for prevention of recurrent bleeding.
- Trial name
- NCT02740166
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 212 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Peptic Ulcer, Bleeding
Effect of IV and Oral Esomeprazole in Prevention of Recurrent Bleeding From Peptic Ulcers After Endoscopic Therapy
The investigators previously showed that the use of a high-dose intravenous PPI regimen after endoscopic control of bleeding from peptic ulcers reduced rate of recurrent bleeding, decreased the need for endoscopic and surgical…
- Trial name
- IOE (NCT01142245)
- Testing
- Oral esomeprazole, Intravenous Esomeprazole
- Where
- 2 sites in China
- Volunteers
- 263 people
- Sponsor
- Chinese University of Hong Kong
Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding
Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
The goal of this randomized controlled clinical trial is to evaluate the efficacy of Tranexamic acid and vitamin K injection versus placebo in control of upper gastrointestinal bleeding (UGIB) in Egyptian cirrhotic patients.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis
- Trial name
- NCT06881628
- Testing
- Tranexamic Acid and vitamin K
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University