Clinical trials: Gene Expression
Adolescents
Adolescents' Non-suicidal Behavior and Perception of Parents' Negative Emotional Expression and Family Communication
The starting point of this project is to study young people and adolescents, aiming to explore the correlation between non-suicidal behavior of young people and adolescents and the negative emotional expression of their parents…
- Trial name
- NCT06290115
- Testing
- Questionnaires set 1, Questionnaires set 2, Questionnaires set 3
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Schizophrenia Disorders, Major Depression
Non-Coding RNAs Gene Expression in Psychiatric Disorders
This study aims to investigate whether specific non-coding RNAs, molecules involved in the regulation of gene expression, are altered in individuals with psychiatric disorders such as schizophrenia, bipolar disorder, major…
- Conditions
- Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD)
- Trial name
- PsiRNA26 (NCT07649993)
- Testing
- Reverse Transcription Quantitative Polymerase Chain Reaction
- Where
- 5 sites in Italy
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Carmen Concerto
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Study During Pregnancy of Expression of miRNAs in RA or SLE
Rheumatoid arthritis (RA) is a systemic disease, which mainly targets joints and results in osteoarticular destruction and serious disability.
- Trial name
- SPIRALE (NCT02350491)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Gene Expression Profiling, Gastric Intestinal Metaplasia
Gene Expression Profiling in Human Gastric Intestinal Metaplasia Mucosa and Duodenal Mucosa
To analyze the genome pattern in human gastric Intestinal Metaplasia Mucosa and duodenal Mucosa.
- Conditions
- Gene Expression Profiling, Gastric Intestinal Metaplasia, Duodenum
- Trial name
- NCT02846688
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Shandong University
Poor Ovarian Response
SIRT3 Expression in Granulosa Cells and the Levels of Follicular Fluid Metabolites Among POR Subgroups
The goal of this prospective, observational study is to learn about the pathogenesis and biological target of the subtypes of poor ovarian response (POR) during In vitro fertilization and embryo transfer (IVF-ET).
- Trial name
- POR SIRT3 (NCT06617988)
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University of Traditional Chinese Medicine
Non-melanomatous Skin Cancer, Precancerous Condition
Effect of Solar-Simulated Ultraviolet Radiation on Gene Expression in Unprotected and Sunscreen-Protected Skin of Healthy Adults With Fitzpatrick Skin Type II
RATIONALE: Testing of skin that has been exposed to artificial sunlight may help in understanding the genetic processes involved in the development of skin cancer.
- Trial name
- NCT00099112
- Testing
- microarray analysis, biopsy, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Nasal Polyp, Smoking
The Factors Associated With the Formation of Nasal polyp-a Case Control and Descriptive Study
Nasal polyp is a significant health problem with a prevalence of 4%. It is increased in patients with asthma (7-15%), Cystic fibrosis (39-56%) or aspirin intolerance (36-96%).The quality of life (QOL) is worse than in patients…
- Conditions
- Nasal Polyp, Smoking, Rhinosinusitis, Allergic Rhinitis
- Trial name
- ACAAGSONP (NCT01278719)
- Where
- India
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karnataka Institute of Medical Sciences
Obesity
Effect of Oryza Sativa l Extract to LPS, ZO-1, and Intestinal Microbiota in Obese Individuals
Background : Obesity prevalence rises among adults and leads to morbidity and mortality due to subsequent inflammation pathway activation.
- Trial name
- NCT04827628
- Testing
- Oryza Sativa Extract, Control
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Fertility
Time Course of Endometrium's Gene Expression Profiles Using Endometrial Tissue and Blood Samples
This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.
- Trial name
- NCT06786273
- Testing
- Small RNA sequencing
- Where
- Taiwan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Inti Labs
Breast Pumping
Testing of New Method in Sanitizing Breast Pump Equipment in the NICU
This study will evaluate a newly developed device, Q. Basin. The Q. Basin is a multifunctional, single patient use device that can sanitize breast pump parts, bottles, and reusable feeding devices for patients admitted under one…
- Trial name
- NCT05248828
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Allergic Rhinitis
Integrative Omics Approach to Allergic Rhinitis
Nasal mucus and nasal epithelium are the first defense barriers against allergens. Various proteins are found in nasal mucus that play a role in allergic rhinitis and reflect immune response to allergen exposure.
- Trial name
- IntegOmics (NCT03324100)
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Gut Microbiota, Gastrointestinal Symptoms
Mother-Infant Cohort Study in Malaysia and China
This mother-infant cohort study aims to determine the geographic differences in the microbial profiles in breast milk from mothers living in Malaysia and China that are potentially important determinants of infant development.
- Conditions
- Gut Microbiota, Gastrointestinal Symptoms, Temperament, Eczema
- Trial name
- NCT04919265
- Testing
- No intervention - mother-infant cohort study
- Where
- Malaysia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Sensation Diminished, Pinprick, Pain
Tactile and Pain Sensory Thresholds and Hand Grip Strength
The aim of this study was to compare fingertip tactile sensation, hand and finger grip strength, and hand pain thresholds in children diagnosed with specific learning disorder with impairment in written expression and healthy…
- Conditions
- Sensation Diminished, Pinprick, Pain, Specific Learning Disorder, With Impairment in Written Expression
- Trial name
- NCT07533409
- Testing
- Treatment outcome
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Sultan 1. Murat State Hospital
Uveitis
Uveitis Gene-Expression Profiling
Uveitis is a group of troublesome diseases that collectively represent a cause of blindness comparable to diabetes. Most forms of uveitis are either infectious or immune-mediated.
- Trial name
- NCT00874471
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Diabetes, Diabetes Mellitus, Type 1
Evaluation of Biomarker Expression in Diabetic and Healthy Subjects Over a One Year Period
This study is conducted in the United States of America (USA). The aim of this study is to assess longitudinal variation of immune biomarkers in subjects with type 1 diabetes (T1D), type 2 diabetes (T2D) and healthy, non-diabetic…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT01900834
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Seaweed Associated Changes in Healthy Subjects
Dietary Seaweed and Early Breast Cancer: A Randomized Trial
Could daily consumption of seaweed help explain lower postmenopausal breast cancer (BC) incidence and mortality rates in Japan? This small proof of principle clinical trial was designed to test the idea that the same amount of…
- Trial name
- NCT01663792
- Testing
- Seaweed
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Aging
Infrared and Broadband Light for Skin Aging
In this exploratory study, we hope to learn if treatment of broadband light with infrared light can alter the molecular pathways associated with aging.
- Trial name
- NCT03243981
- Testing
- Sciton SkinTyte (800-1800 nm) with Broadband Light Technology
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Obstructive Pulmonary Disease
Expression of miR-204 and Consequences on Capillarization in Limb Muscles of Patients With COPD
Limb muscle dysfunction, characterized by loss of capillaries, is amongst the most troublesome systemic consequences of chronic obstructive pulmonary disease (COPD) leading to poor functional status and premature mortality.
- Trial name
- NCT02903043
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Laval University
Pharmacogenomics, Systems Biology
Progestagen Type in Postmenopausal Hormone Therapy and Blood Gene Expression Profile
The purpose of this study is to compare combined postmenopausal hormone therapy natural progesterone to the one containing synthetic progestagen (i.e. chlormadinone acetate) at the blood transcriptome level.
- Trial name
- ProGEP (NCT01123538)
- Testing
- Progesterone, Chlormadinone acetate
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway