Clinical trials: Generations
COVID-19
A 2nd Generation E1/E2B/E3-Deleted Adenoviral COVID-19 Vaccine: The TCELL VACCINE TRIAL
This is a phase 2/3, multicenter, randomized, placebo-controlled, observer-blind study assessing the safety, tolerability, immunogenicity, and efficacy of prophylactic hAd5-S-Fusion+N-ETSD against COVID-19.
- Trial name
- NCT06022224
- Testing
- hAd5-S-Fusion+N-ETSD
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ImmunityBio, Inc.
Familial Lipomatosis, Very Rare Dermatologic Diseases
Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
The primary purpose of the protocol is to use next generation sequencing to identify pathogenic variants in genes involved in very rare skin diseases.
- Trial name
- DERMA-SEQ (NCT02509650)
- Where
- 2 sites in France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Ageing
Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study
Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.
- Trial name
- GEN100 (NCT01666340)
- Testing
- Exercise intervention
- Where
- Norway
- Volunteers
- 1,567 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Healthy Volunteers
Generation of Biological Samples Positive to Hydromorphone for Anti-doping Control
Background: Hydromorphone (HM) is a semi-synthetic derivative of morphine used for pain control. Like other opiates, due to its high potential of abuse HM is included on the World Anti-Doping Agency (WADA) list of prohibited…
- Trial name
- HM (NCT04081376)
- Testing
- Hydromorphone Hydrochloride
- Where
- Spain
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Low Immunization Uptake
Tunatar da ni. The Immunization Reminder and Information SMS System (IRISS)
In 2016, only 33% of Nigerian children aged 12-23 months had been vaccinated with the 3rd dose of the pentavalent vaccine. Lack of knowledge was the leading reason for non-vaccination.
- Trial name
- IRISS (NCT04001322)
- Testing
- Community engagement, IRISS advert for opt-in, One-time SMS broadcast on immunization
- Where
- Nigeria
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Genetic Disorders
Clinical Implementation of Carrier Status Using Next Generation Sequencing
This study is conducting a randomized controlled trial (RCT) with up to 400 subjects (women \& partners) seeking pre-conception carrier testing to assess the impact of the program using Whole Genome Sequencing (WGS). 1.
- Trial name
- NextGen (NCT01902901)
- Testing
- Whole Genome Sequencing, Carrier status testing
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Contribution of Ethanol on Hydroxytyrosol Formation
Relevance of the Ethanol Dose in the Generation of Endogenous Hydroxytyrosol
Health benefits for humans derived from low dose intake of ethanol could partially be explained by its interaction with dopamine (DA) oxidative metabolism.
- Trial name
- NCT01788670
- Testing
- Ethanol, Water
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Electrical Stimulation
Influence of Electrode Positioning and Current Type on Fatigue, Force and Discomfort
Introduction: Neuromuscular electrical stimulation (NMES) has the purpose of generating muscle contractions to minimize muscular atrophy and to improve neuromuscular performance.
- Trial name
- NCT04200677
- Testing
- Monophasic Current (100 Hz) with 1ms pulse width applied to the Tibial Nerve, Biphasic current (100 Hz) with pulse width 0.5ms applied to the Tibial Nerve, Biphasic current (100 Hz) with 1ms pulse width applied to the Tibial Nerve
- Where
- 2 sites in Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Neonatal Vitamin A Supplementation
Efficacy of Newborn Vitamin A Supplementation Versus Placebo in Improving Child Survival (NeoVitA Trial)
The study is a large randomized controlled trial to assess the efficacy and safety of neonatal vitamin A supplementation administered to neonates once orally either on the day of birth or in the next 2 days in improving infant…
- Trial name
- NCT01138449
- Testing
- Vitamin A
- Where
- India
- Volunteers
- 44,984 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
HIV Infections, Syphilis
Estimating the Incidence of HIV Infection Among Men Who Have Sex With Men in Peru and Ecuador
The purpose of this observational study is to estimate the number of new HIV infections and the number and variability of antiretroviral-resistant HIV strains among men who have sex with men (MSM).
- Conditions
- HIV Infections, Syphilis, Sexually Transmitted Diseases
- Trial name
- NCT00279331
- Where
- 6 sites in Ecuador, Peru
- Volunteers
- 2,608 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Preterm Rupture of Membranes
Identification of Microbial DNA in Maternal Plasma After PPROM
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
- Trial name
- NCT04318470
- Testing
- mNGS
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, Prenatal Care
Comparing AI and Standard Pregnancy Chatbots
Many pregnant women in India use mobile phones to get health information. Nivi runs a free WhatsApp service called askNivi that answers questions about pregnancy and sends reminders about prenatal care visits.
- Conditions
- Pregnancy, Prenatal Care, Maternal Health
- Trial name
- NCT07883993
- Testing
- Scripted maternal health chatbot, MATRI retrieval-augmented maternal health chatbot
- Where
- India
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Nivi, Inc.
Stress, Stress-related Problem
Mental Health of the Polycrisis Generation
The goal of this observational, longitudinal study is to identify risk and protective factors that buffer the effects of individual daily stress and adaptation to global crises on the quality of life and mental health conditions…
- Conditions
- Stress, Stress-related Problem, Cumulative Trauma, Mental Health Issue
- Trial name
- NCT06515704
- Where
- 2 sites in Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Type 1 Diabetes
Accuracy, Reliability and Safety of GlucoMen®Day, a New Generation Microdialysis Continuous Glucose Monitor
Monocenter single-arm, prospective clinical study in 20 type 1 diabetic subjects, equipped with the GlucoMen®Day system, over up to 100 hours observation after implantation of the microdialysis probe.
- Trial name
- NCT01407315
- Testing
- GlucoMenDay
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cancer
Cost of Cancer Diagnosis Using Next-generation Sequencing Targeted Gene Panels in Routine Practice
The aim of this study was to measure the total cost of performing next-generation sequencing (NGS) in clinical practice in France, in both germline and somatic cancer genetics.
- Trial name
- NCT04656717
- Testing
- Measure of the total cost of performing next-generation sequencing (NGS)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Urologic Diseases
Bioequivalence Study of the Second Generation Dutasteride and Tamsulosin Hydrochloride (HCL) Combination Capsule in Fasted State
The purpose of this study is to assess the bioequivalence of the second generation dutasteride and tamsulosin hydrochloride (HCL) combination capsule versus currently available commercial combination of dutasteride 0.5 milligram…
- Trial name
- NCT02052713
- Testing
- Commercially available combination of dutasteride 0.5 mg and tamsulosin HCL 0.4 mg, Second generation dutasteride 0.5 mg and tamsulosin HCL 0.4 mg combination capsule
- Where
- United Kingdom
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Normal Subject, Patient With Pharmaco-resistant Epilepsy
Helium 4 Optically Pumped Magnetometers : a New Generation of Sensors for High Speed Functional Brain Imaging
Our goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography sensors (OPM He4) to record brain magnetic activities.
- Trial name
- NEW MEG (NCT04615637)
- Testing
- MEG recordings
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Generation of Reactive Oxygen Species, Intestinal Inflammation
Assessment of Complementary Feeding of Canadian Infants
With the recent recommendation from Health Canada to extend exclusive breast-feeding to 6 months of age there has arisen concern about what is the best solid food to introduce at that time.
- Trial name
- Infant Feeding (NCT01790542)
- Testing
- Iron fortified cereal, Iron fortified cereal with fruit, Meat
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Overweight and Obesity
Next-Generation Synbiotic in Individuals With Overweight or Obesity
This study plans to evaluate the effect of consuming a symbiotic (probiotic + prebiotic) for 3 months on body weight, body composition, glucose sensitivity, and psychological parameters, as well as on gut and blood microbial…
- Trial name
- NCT06213480
- Testing
- Synbiotic Group
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Texas Christian University