Clinical trials: Generations
Neutrophil-mediated Inflammatory Dermatoses, Inflammatory Dermatoses
Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
This study is to identify rare, disease-causing mutations of several rare neutrophil dermatoses. To identify associations between NMID and variants in the genome next generation sequencing, mainly whole exome sequencing, will be…
- Trial name
- NEUTROSKIN (NCT05732987)
- Testing
- Analysis of samples
- Where
- Switzerland
- Volunteers
- 3,370 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infant, Newborn
Whole Exome Screening of Newborns
The aim of the study is to obtain the initial experience of the inclusive genetic screening of newborn. Two groups of newborns born in RCOGP will be enlisted to the study: 1.
- Trial name
- NCT05325749
- Testing
- Screening, Family history record, Questionnaire survey
- Where
- Russia
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Changes Associated With H. Pylori and Gastric Carcinogenesis
This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care.
- Trial name
- IIT H pylori (NCT02164409)
- Testing
- Endoscopy tissue collection
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy Volunteers
Normal Values of Parameters of Thrombin Generation in Function of Different Tissue Factor Concentrations
The thrombin generation assay (TGA) is a good tool for measuring clot formation in plasma.TGA using Calibrated Automated Thrombography method, enables the quantification of thrombin concentrations in platelet-rich plasma (PRP)…
- Trial name
- NUAGE (NCT04842084)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Beta Thalassemia Major Anemia
Thrombin Generation in Beta-thalassemia Major
This study aims to evaluate the persistence of a hypercoagulable state in chronically-transfused patients with beta thalassemia major, by using the thrombin generation test (performed in whole blood and plasma).
- Trial name
- TG-THAL (NCT04962984)
- Testing
- blood sampling
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Difficult Intubation
Comparing the Efficiency of Three Third-generation Supraglottic Airways as an Intubation Route
A "can't intubate, can't oxygenate" situation is life-threatening and the physician must be prepared to react quickly. Similarly, a difficult intubation with adequate ventilation is associated with complications.
- Trial name
- NCT02975466
- Testing
- Insertion of AirQ Blocker and intubation through the device, Insertion of AuraGain and intubation through the device, Insertion of I-Gel and intubation through the device
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Diabetes Mellitus, Sport Injury
Cryopreserved Hair Follicles for Disease and Cell Replacement
To explore the application of cells expanded from plucked hair follicles after collection, transport, and cryopreservation, in disease modeling and cell-based therapies.
- Conditions
- Diabetes Mellitus, Sport Injury, Injury Traumatic
- Trial name
- NCT06764719
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Acorn Biolabs Inc.
School Readiness
Broader Implementation of a Successful Dual-Generation Intervention in Partnership With Head Start of Lane County
This project involves the development of a scaled-up model of a successful dual-generation intervention targeting attention, stress, and self-regulation in families attending Head Start, and improvements of outcome assessments of…
- Trial name
- NCT02945384
- Testing
- Creating Connections: Strong Families, Strong Brains
- Where
- United States
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Healthy Volunteers
Generation of Biological Samples Positive to Hydrochlorothiazide for Anti-doping Control
Background: Hydrochlorothiazide is a diuretic that inhibits the reabsorption of sodium and chloride in the renal tubules, thus increasing the excretion of water.
- Trial name
- HCTZ (NCT04197622)
- Testing
- Hydrochlorothiazide
- Where
- Spain
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Healthy
A Study to Evaluate the Reactogenicity, Safety, and Immunogenicity of the Third Generation Hepatitis B Vaccine
A single center, randomized, double blinded phase I/IIa exploratory study to evaluate reactogenicity, safety, immunogenicity and dose-response of a new hepatitis B vaccine in human adult
- Trial name
- NCT02692170
- Testing
- CVI-HBV-001, Conventional Hepatitis B vaccine (20 μg)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aribio Lab Co., Ltd.
Covid19, Interstitial Pneumonia
Identification of Predictors for the Evolution of COVID-19 Related Pneumonia by Transcriptomic and Seroproteomic
The investigating group aims at performing an observational, prospective study that involves the evaluation of circulating biomarkers predictive of clinical evolution in patients suffering from COVID-19 disease.
- Trial name
- COVID_OMICS (NCT04441502)
- Where
- Italy
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Feasibility
Microenterprise Intervention to Reduce Sexual Risk Behaviors in Young Adults
The study team will conduct a two-group study to examine the feasibility of implementing an enhanced microenterprise intervention to reduce sexual risk behaviors. The team will enroll approximately 40 young adults.
- Trial name
- EMERGE (NCT03766165)
- Testing
- Intervention, Control
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Healthy
A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser
This research study aims assess whether the Difference Frequency Generation (DFG) laser could be a better alternative to the CO2 laser in terms of reduced side effects and patient downtime.
- Trial name
- NCT06295471
- Testing
- DFG Laser, CO2 Laser, Optical coherence tomography (OCT)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Reference Values
Generation of Standard Laboratory Values for Pneumococci Antibodies
The determination of reference values is a necessary basis for research and clinical routine testing for pneumococci antibodies
- Trial name
- NCT00567632
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Primary Care
Relisten: Enhancing Care Quality and Saving Time With Automatic Clinical Note Generation in Primary Care
Background: Relisten is an artificial intelligence-based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between healthcare professionals and patients.
- Trial name
- Relisten (NCT06618092)
- Testing
- Relisten
- Where
- 6 sites in Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Alcohol Drinking, Alcohol Intoxication
Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms
The study will employ a combined laboratory-ambulatory design. Participants will engage in ambulatory assessment over the course of 14 days, wearing biosensors assessing transdermal alcohol concentration (TAC) and providing…
- Trial name
- NCT05692830
- Testing
- Alcohol
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Chronic Obstructive Pulmonary Disease
A Study to Assess the Pharmacokinetics and Safety of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) With a Next-Generation Propellant (NGP) With a Spacer, BGF MDI Hydrofluoroalkane (HFA) With a Spacer, as Well as BGF MDI NGP Without a Spacer
This study aims to assess the effect on total systemic exposure and to characterize exposure BGF MDI HFO with a spacer compared to without a spacer; also, to demonstrate that total systemic exposure of BGF when administered as…
- Trial name
- NCT06297668
- Testing
- Treatment A: BGF MDI HFA, Treatment B: BGF MDI HFO, Treatment C: BGF MDI HFO
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
BCL2 Gene mRNA Overexpression
Validation of Useful Markers Generated by Next Generation Bio-data Based Genome Research and Cohort Study
Multiple biomarker development through validation of useful markers generated by next generation bio-data based genome research and cohort study
- Trial name
- miRNA_Chip (NCT02807896)
- Where
- South Korea
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- CHANGHEE LEE
Functional Dyspepsia
Duodenal Microbiota in Functional Dyspepsia
The goal of this observational study is to assess the type of duodenal microbiota and duodenal microbiome in in FD patients compared to control group.
- Trial name
- NCT06326918
- Testing
- Duodenal mucosal brushing, Duodenal mucosal biopsy
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Stress, Stress-related Problem
Mental Health of the Polycrisis Generation
The goal of this observational, longitudinal study is to identify risk and protective factors that buffer the effects of individual daily stress and adaptation to global crises on the quality of life and mental health conditions…
- Conditions
- Stress, Stress-related Problem, Cumulative Trauma, Mental Health Issue
- Trial name
- NCT06515704
- Where
- 2 sites in Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University