Clinical trials: Generations
Insomnia
The Long-term Impact of Massage Chairs on Sleep Quality.
Modern technology is reshaping the massage industry, improving relaxation and well-being with pioneering devices. The automatic massage chairs stand as a testament to this evolution, integrating ergonomic design with advanced…
- Trial name
- autosleepilot (NCT06788288)
- Testing
- Massage Chair session, Washout period
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Thessaly
Cirrhosis, Liver
Microbiome Translocation in Different Circulatory Compartments in Decompensated Cirrhosis
Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections contributing to disease progression and may lead to the development of acute-on-chronic liver failure (ACLF).
- Trial name
- NCT04195724
- Testing
- mNGS for pathogen detection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Functional Dyspepsia
Duodenal Microbiota in Functional Dyspepsia
The goal of this observational study is to assess the type of duodenal microbiota and duodenal microbiome in in FD patients compared to control group.
- Trial name
- NCT06326918
- Testing
- Duodenal mucosal brushing, Duodenal mucosal biopsy
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Breast Cancer, Arthralgia
Loss of Grip Strength, BMI, and Adjuvant Endocrine Therapy Breast Cancer
Early stage hormone receptor positive breast cancer is typically treated with adjuvant endocrine therapy in order to decrease risk of breast cancer recurrence and to improve overall survival from the disease.
- Conditions
- Breast Cancer, Arthralgia, Obesity
- Trial name
- LOGRIBMET (NCT01896050)
- Testing
- anastrozole, letrozole, exemestane, Tamoxifen
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Michigan Rogel Cancer Center
Whole Genome Sequencing
Ultra Rapid GEnome Sequencing
Next-generation sequencing (NGS) has revolutionized the field of genomics, allowing the detection of genetic abnormalities for diagnostic or therapeutic purposes.
- Trial name
- URGES (NCT06555731)
- Testing
- Ultra rapid genome sequencing
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- CMC Ambroise Paré
Triple Negative Breast Cancer
Cellular Immune Responses in Triple-negative Breast Cancer - High Throughput Immunogenetic Studies
This project introduces a novel methodology for the in-depth immunogenetic characterization of the TR gene repertoire in solid tumors, holding the promise to offer unprecedented insights into the TR anti-tumor specificity and the…
- Trial name
- NCT06646263
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Institute of Applied Biosciences
Healthy Volunteers
Generation of Biological Samples Positive to Salmeterol for Anti-Doping Control
Background: In terms of doping, there is controversy regarding the beneficial effects of β2-agonists like salmeterol on physical performance.
- Trial name
- SALM (NCT04195867)
- Testing
- Salmeterol Xinafoate
- Where
- Spain
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Lung Cancer
Clinical and Molecular Staging of Lung Cancer Stages I and IIp
The classification of lung cancer (LC) according to the degree of anatomical extension (TNM) allows the estimation of the prognosis of the patient, although its accuracy is limited.
- Trial name
- NCT03286036
- Testing
- biomarkers
- Where
- 4 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Corporacion Parc Tauli
Rare Malignant Neoplasm
Marker Assisted Selective ThErapy in Rare Cancers: Knowledge Database Establishing registrY Asia
This is a registry study that aims to collect patients' data with advanced-stage rare cancer in Asia-Pacific region. Data includes clinical information, details of treatment, prognosis, pathological diagnosis and genetic…
- Trial name
- MASTERKEY ASIA (NCT05217407)
- Testing
- Genomic sequence
- Where
- 18 sites in Japan, Malaysia and 5 more
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Center, Japan
Cirrhosis
Thrombin Generation Test in Patient With Liver Cirrhosis
Cirrhotic patients are patients with high morbidity and mortality, it is very important for determining the prognosis of these patients. The importance increases when these patients waiting for a liver transplant.
- Trial name
- NCT02484534
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- HaEmek Medical Center, Israel
Type 2 Diabetes Mellitus
Efficacy Study of the DIAMOND System to Treat Type 2 Diabetes Mellitus
The study purpose is to demonstrate the benefit of a simplified version of the DIAMOND System (A third Generation) in comparison to a sham treatment in terms of Glycemic control, measured as A1c, FBG and Post-Prandial Glucose…
- Trial name
- RUBY (NCT01529216)
- Testing
- DIAMOND System
- Where
- 2 sites in France, Netherlands
- Volunteers
- 2 people
- Sponsor
- MetaCure Limited
Myeloma Multiple
Study of Daratumumab in Multiple Myeloma (MM) Patients in >VGPR/MRD-positive
Aim of this study is to evaluate Daratumumab effect on MRD-positive patients with Multiple Myeloma (MM) who achieved >VGPR after any therapy (ASCT, VMP, Rev-Dex).
- Trial name
- DART4MM (NCT03992170)
- Testing
- Daratumumab
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Newborn; Infection
Pilot Study - Monitoring the Nasal Microbiome and Viral Respiratory Infections in Newborn Hospitalized in Neonatalogy.
The objective of our study is therefore to study the evolution of the respiratory microbiome of hospitalized newborns, its interaction with viral infections and their impacts on the evolution of newborns.
- Trial name
- NEONATMICROBIO (NCT06389383)
- Testing
- Nasal Swab
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Caen
Breast Cancer, Early Breast Cancer
A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who…
- Trial name
- CAMBRIA-1 (NCT05774951)
- Testing
- Camizestrant, Tamoxifen, Anastrozole
- Where
- 709 sites in United States, Argentina and 37 more
- Volunteers
- 4,300 people
- Sponsor
- AstraZeneca
Non-small Cell Lung Cancer, ALK-Positive Lung Cancer
Plasma Molecular Profiling in ALK Inhibitor Resistant NSCLC
The investigators plan to understand a comprehensive molecular profiling via the plasma, with the primary aim of using this form on analysis to guide subsequent treatment selection.
- Trial name
- NCT04087473
- Where
- 5 sites in Hong Kong, Malaysia and 2 more
- Volunteers
- 50 people
- Sponsor
- National Cancer Centre, Singapore
Biliary Tract Cancer (BTC)
The Registry of Genetic Alterations of Taiwan Biliary Tract Cancer
Recent progress in comprehensive genomic profiling for advanced BTC has helped to clarify tumorigenesis and facilitate the coming era of precision medicine.
- Trial name
- NCT05036486
- Testing
- next-generation sequencing
- Where
- 13 sites in Taiwan
- Volunteers
- 480 people
- Sponsor
- National Health Research Institutes, Taiwan
Leptomeningeal Metastasis From Lung Cancer
ctDNA-driven Adaptive Proton Craniospinal Irradiation in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis After Resistance to Third-Generation TKIs in the Consolidation Phase
Brief Summary (English) The goal of this clinical trial is to learn if a risk-adaptive consolidation therapy, guided by cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) clearance kinetics after induction intrathecal…
- Trial name
- NCT07751536
- Testing
- proton craniospinal irradiation, Intrathecal pemetrexed
- Where
- 3 sites in China
- Volunteers
- 84 people
- Sponsor
- Shuanghu Yuan
Clear Cell Renal Cell Carcinoma
Biomarker Study of Pts With Metastatic ccRCC Undergoing Sequential Therapy With 1st Line Sunitinib and 2nd Line Axitinib
This is a prospective single arm phase II study to evaluate potential prognostic and/or predictive biomarkers in patients with metastatic ccRCC undergoing treatment with 1st line sunitinib on a 4/2 schedule followed by axitinib…
- Trial name
- SuAx (NCT03592199)
- Testing
- Sunitinib
- Where
- Brazil
- Volunteers
- 7 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Adult Patients Who Declare an Allergy to Penicillin During Anaesthetic Consultation Without Any Allergy Work up That Could Confirm This Declaration, Good Comprehension of French Language
Assessment of the Applicability and Acceptability of an Algorithm to Guide the Prescription of 1st and 2nd Generation Cephalosporins as Part of Intraoperative Antibiotic Prophylaxis in Patients With a Declared Allergy to Penicillin
According to the Centers for Disease Control and Prevention (CDC), a surgical site infection (SSI) is an infection that occurs after surgery at the site where the surgery was performed.
- Trial name
- PROPHYLAL (NCT06067919)
- Testing
- decision tree for the choice of intraoperative antibiotic prophylaxis
- Where
- France
- Volunteers
- 275 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Infertility, Male
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
Multi-centered, randomized controlled study, evaluating the safety and efficacy of the Ohana IVF Sperm Preparation Kit vs. a standard IVF sperm preparation kit.
- Trial name
- SPRING (NCT04142112)
- Testing
- Ohana IVF Sperm Preparation Kit (OHB035), Standard IVF Preparation Kit (OHB037)
- Where
- 7 sites in United States
- Volunteers
- 83 people
- Sponsor
- Ohana BioSciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.