Clinical trials: Genome
Knowledge, Attitudes, Practice
Public Perception and Policy for SARS-CoV-2 Whole Genome Sequencing and Genomics for All
Gap in understanding undermines government and public support for SC2-WGS, and other wide-scale genomic sequencing (Gut microbiome, Genome Wide Sequencing for Prenatal Detection, Tuberculosis Metagenomic sequencing, Nutrigenetics…
- Trial name
- NCT06441981
- Testing
- Education
- Where
- Indonesia
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Prenatal, Genome-wide High Throughput Sequencing
ANDDI-PRENATOME - Feasibility Study for a " Fast " Pangenomic High Throughput Sequencing Analysis in Prenatal Diagnosis
Prenatal diagnosis of genetic diseases is a real medical challenge. The discovery of antenatal abnormalities on ultrasound is frequent (5 to 10% of pregnancies), and when an abnormalities is seen on ultrasound, it raises the…
- Trial name
- AnddiPrenatome (NCT03964441)
- Testing
- Invasive fetal sampling, blood sampling of mother and father, blood sampling from the mother to recover the circulating cell free fetal DNA, Parent interviews (optional organizational study)
- Where
- France
- Volunteers
- 149 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Multiple Myeloma
Genomic-Based Diagnosis, Classification and Targeted Treatment of Multiple Myeloma
Multiple myeloma is an incurable bone marrow cancer characterized by an abnormal expansion of plasma cells that secretes monoclonal immunoglobulin.
- Trial name
- NCT01619358
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Breast Cancer, Nipple Discharge
A Study on Combined Low-pass Whole-genome and Methylome Testing of Bloody Nipple Discharge Specimens for Benign-Malignant Differentiation.
This is a prospective, single-center diagnostic study testing whether a new, minimally invasive analysis of nipple fluid can distinguish benign from malignant causes of pathologic nipple discharge.
- Trial name
- NCT07250204
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Psychosis
Multiomic Diagnostics in Youth With Psychosis
Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic…
- Trial name
- NCT05457140
- Testing
- Genetic: Genomic sequencing and molecular diagnostic results, if any., Phage display ImmunoPrecipiation Sequencing (PhIP-Seq)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rady Pediatric Genomics & Systems Medicine Institute
NSCLC Stage IV, Brain Metastases
Genomic Study in Non-small Cell Lung Cancer Brain Metastasis
The investigators collected the data from the investigators' center between January 2011 and October 2020. The study included all non-small cell lung cancer patients with surgically excised brain metastasis.
- Trial name
- NCT04745715
- Testing
- craniectomy
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Cheng-Kung University Hospital
Multiple Sclerosis, MS
Evaluating Multiple Sclerosis Patients ShOWing A GEnomic Signature of Therapy Response
To develop a test to characterize and monitor Multiple Sclerosis (MS) disease status and therapy response from a participant's home by analyzing the gene expression from participant self-collected blood samples using a novel…
- Trial name
- EMPOWER (NCT03316404)
- Where
- United States
- Volunteers
- 1,168 people
- Sponsor
- DxTerity Diagnostics
Breast Cancer
Standard Neoadjuvant Chemotherapy Versus Genomic Driven Chemotherapy in Patients With Breast Cancer
This randomized trial is comparing a standard neoadjuvant chemotherapy with a genomic driven chemotherapy in patients with breast cancer.
- Trial name
- REMAGUS04 (NCT01180335)
- Testing
- Chemotherapy, Genomic driven chemotherapy
- Where
- France
- Volunteers
- 303 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Malignant Neoplasm
Targeted Genomic Analysis of Blood and Tissue Samples From Patients With Cancer
This research trial studies the use of targeted genomic analysis of blood and tissue samples from patients with cancer. Genomic sequencing is a laboratory method that is used to determine the entire genetic makeup of a specific…
- Trial name
- NCT02688517
- Testing
- Cytology Specimen Collection Procedure, Laboratory Biomarker Analysis
- Where
- 11 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Rutgers, The State University of New Jersey
Familial Pancreatic Cancer
Understanding Genetic Incidental Findings in Your Family (UNIFY Study)
Currently, there is no clear legal or ethical guidance about how researchers and IRBs ought to proceed when the research participant in a biobank is deceased and there is clinically relevant information that could be disclosed to…
- Trial name
- UNIFY (NCT02560896)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Alcoholic Liver Disease, Severe Alcoholic Hepatitis
Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease
Alcoholic hepatitis carries a risk of high mortality at short term, especially in its severe form. Its diagnosis is confirmed by liver biopsy.
- Conditions
- Alcoholic Liver Disease, Severe Alcoholic Hepatitis, Alcoholic Cirrhosis
- Trial name
- COMADHAA (NCT04106518)
- Where
- 9 sites in France
- Volunteers
- 447 people
- Sponsor
- University Hospital, Lille
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Breast Cancer, Breast Neoplasms
A Study of Breast Cancer Risk Factors and Outcomes of People in Florida
The purpose of this study is to understand why different people have different risks and outcomes for breast cancer and non-breast cancer.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Diseases
- Trial name
- NCT06780176
- Testing
- Biospecimen Collection, Surgical Tissue Collection, Survey Collection
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Carcinoma, Non-Small-Cell Lung, Non-small Lung Cancer
Genomic Landscape of Ceritinib
The investigators propose to conduct a retrospective study of single agent ceritinib in patients with previously untreated anaplastic lymphoma kinase (ALK) rearranged adenocarcinoma of the lung with the sole purpose of…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Non-small Lung Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT02554591
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Washington University School of Medicine
Whole Genome Sequencing
South-seq: Deoxyribonucleic Acid (DNA) Sequencing for Newborn Nurseries in the South
2,000 infants with signs suggestive of a genetic disorder being treated at a neonatal intensive care unit (NICU) in which African-American and rural populations are highly represented will be enrolled.
- Trial name
- NCT03842995
- Testing
- Genetic Counselor, Trained Healthcare Provider
- Where
- 3 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Interstitial Lung Disease, Interstitial Fibrosis
Integrating Molecular, Genomic, Morphology and Environmental Features to Improve Precision Diagnosis and Treatment in Interstitial Lung Diseases (PRECISION-ILD)
Integrating Molecular, Genomic, Morphology and Environmental Features to Improve Precision Diagnosis and Treatment in Interstitial Lung Diseases (PRECISION-ILD) Background: Interstitial Lung Diseases (ILDs) are a heterogeneous…
- Trial name
- PRECISION-ILD (NCT05998512)
- Testing
- Observational register
- Where
- 3 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Genetic Conditions
TRIAGE-GS: Towards Reducing Inefficiencies Affecting Genetics Encounters Through Genome Sequencing
Individually rare genetic diseases are collectively common, and affect many Canadian families. Making the right diagnosis is both important and challenging.
- Trial name
- TRIAGE-GS (NCT06935019)
- Testing
- Genome sequencing pre-geneticist evaluation
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- The Hospital for Sick Children
Multiple Myeloma
Detecting Minimal Residual Diseases (MRD) and Monitoring Clonal Evolution Using Ultrasensitive Chromosomal Aberrations Detection (UCAD) in Multiple Myeloma
The presence of minimal residual disease (MRD) is an important prognostic factor for multiple myeloma, while copy number variation (CNV) is a widely accepted biomarker used for multiple myeloma (MM).
- Trial name
- NCT06302699
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
Treatment for Advanced Non-small Cell Lung Cancer With Actionable Genomic Alterations After Targeted Treatment and Chemotherapy (An Expanded Lung-MAP Treatment Trial)
This phase II Expanded Lung-MAP treatment trial compares how well sacituzumab govitecan alone, ivonescimab alone, or sacituzumab govitecan in combination with ivonescimab works in treating patients with non-small cell lung cancer…
- Trial name
- NCT07393555
- Testing
- Biospecimen Collection, Computed Tomography, Ivonescimab
- Where
- 41 sites in United States
- Volunteers
- 117 people
- Sponsor
- SWOG Cancer Research Network
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