Clinical trials: Ghrelin, open to volunteers
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Growth Hormone Deficiency (GHD)
Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency
The OraGrowtH Phase 3 Trial is a multi-national trial. The goals of the trial are to study LUM-201 as a treatment for Pediatric Growth Hormone Deficiency (PGHD) in naive to treatment children and validate the LUM-201 predictive…
- Trial name
- NCT06948214
- Testing
- LUM-201
- Where
- 55 sites in United States, Argentina and 6 more
- Volunteers
- 150 people
- Sponsor
- Lumos Pharma
Eating Disorder, Bulimia Nervosa
Co-Feedback Action of Growth Hormone, PP and PYY on Ghrelin in Bulimia
This study evaluates the addition of Acipimox or placebo to exercise on growth hormone release and ghrelin secretion in bulimic patients and in healthy women.
- Trial name
- NCT03338387
- Testing
- Acipimox
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Obesity, Bariatric Surgery
Eating Behavior, Nutritional Status and Appetite Hormones After Bariatric Surgery
This study aims to evaluate changes in eating behavior attitudes, nutritional status, and appetite-regulating hormonal parameters in individuals who have undergone Laparoscopic Sleeve Gastrectomy (LSG).
- Conditions
- Obesity, Bariatric Surgery, Laparoscopic Sleeve Gastrectomy, Eating Behavior
- Trial name
- BCKYL-YDB (NCT07636239)
- Testing
- Anthropometric Measurements and Dietary Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Özlem ÖZPAK AKKUŞ
Anorexia Nervosa
Remission Factors in Anorexia Nervosa
Anorexia Nervosa (AN) is a complex and multifactorial psychiatric disease that affects mostly women and is characterized by a self-restriction of food intake leading to life-threatening consequences whose underlying mechanisms…
- Trial name
- REMANO (NCT04560517)
- Where
- France
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart Failure With Reduced Ejection Fraction (HFrEF)
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
The primary purpose of the study is to evaluate the safety and efficacy of 2 doses of AC01 compared to placebo over 12 weeks in participants with chronic advanced HFrEF.
- Trial name
- GOAL-HF2 (NCT07584967)
- Testing
- AC01
- Volunteers
- 400 people
- Sponsor
- AnaCardio AB
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Functional Proteins in Polycystic Ovary Syndrome
The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without…
- Trial name
- NCT06793098
- Testing
- Measurement of kisspeptin concentration, Measurement of ghrelin concentration, Measurement of zonulin concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
PARKINSON DISEASE (Disorder), Parkinson
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson Disease, Parkinson s Disease
- Trial name
- Met-Pro (NCT07786116)
- Testing
- Probiotic Supplementation with L. reuteri
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Obesity & Overweight
Investigating the Effects of 24 Hour LEAP2 Infusion in Individuals With Overweight and Obesity
This study investigates whether temporarily blocking the ghrelin receptor affects appetite and food intake in people with overweight or obesity.
- Trial name
- H24LEAP2 (NCT07897383)
- Testing
- Liver-expressed antimicrobial peptide 2
- Volunteers
- 18 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Obesity, Weight Loss
Bariatric Embolization of Arteries for the Treatment of Nonalcoholic Steatohepatitis
Obesity is an epidemic in the US. With progression of obesity, Nonalcoholic steatohepatitis (NASH) has been a growing public health issue.
- Conditions
- Obesity, Weight Loss, Body Weight, Nonalcoholic Steatohepatitis
- Trial name
- NCT02933554
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Keith Pereira, MD:
Obesity
Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)
The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone combined gastric mucosal ablation with endoscopic sleeve gastroplasty at True You…
- Trial name
- NCT06420700
- Testing
- Combined gastric mucosal ablation with endoscopic sleeve gastroplasty
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- True You Weight Loss
Growth Hormone Deficiency
A Long-Term Safety Trial of LUM-201 in Children With Idiopathic Growth Hormone Deficiency Who Have Previously Completed a LUM-201 Clinical Trial (OraGrowtH211)
This is a multi-national trial. The trial aims to study the long-term safety of LUM-201 in subjects with Idiopathic Pediatric Growth Hormone Deficiency (iPGHD).
- Trial name
- OraGrowtH211 (NCT05796440)
- Testing
- LUM-201
- Where
- 7 sites in United States, Australia
- Volunteers
- 60 people
- Sponsor
- Lumos Pharma
Obesity
Fundus Ablation Registry (Gastric Fundus Mucosal Ablation for Weight Loss)
The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone gastric fundus mucosal ablation at True You Weight Loss.
- Trial name
- NCT06428617
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- True You Weight Loss
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis
This observational cross-sectional study will evaluate salivary apelin, chemerin, ghrelin, and lipocalin-2 levels in individuals with different periodontal and systemic conditions.
- Trial name
- NCT07703345
- Testing
- Salivary Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Exercise Physiology, Metabolic Hormones
Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in…
- Trial name
- ILEX (NCT07805772)
- Testing
- Aerobic Exercise, Anaerobic Exercise, High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inonu University