Clinical trials: Gingival Condition
Liver Cancer
Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection
Every patient undergoing surgery in the abdomen, such as hepatic resection, will experience temporary paralysis of bowel function.
- Trial name
- SP/GC-HCC (NCT02649153)
- Testing
- smoked plum, gum chewing
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Chronic Periodontitis, Diabetes Mellitus
Chemerin and IL-6 Levels in Diabetes and Periodontitis
The aims of the present study were to determine the gingival crevicular fluid (GCF) chemerin and interleukin-6 (IL-6) levels and to analyse the relationship between chemerin and IL-6 in periodontal health and in chronic…
- Trial name
- NCT02596581
- Testing
- non-surgical periodontal treatment
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Gingival Recessions, Gingival Recession, Mucogingival Surgery
Histological and Clinical Evaluation of De-epithelialized Connective Tissue Grafts Obtained by Different Methods
This randomized controlled clinical study aimed to evaluate the effectiveness of two different de-epithelialization techniques-extraoral scalpel and intraoral radiofrequency (RF)-used in the preparation of de-epithelialized…
- Trial name
- DEEP-RCT (NCT07521566)
- Testing
- Extraoral de-epithelialization Group, Radiofrequency De-epithelialization
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Gingival Recession
Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession
Gingival recession is defined as the apical migration of gingival margin beyond cemento-enamel junction with the exposure of root surface.
- Trial name
- NCT02835430
- Testing
- Coronally advanced flap and PRF with DFDBA, Coronally advanced flap and PRF without DFDBA
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Hypercholesterolemia
The Effect of BiosLife on Serum Lipids
This is a double-blind, placebo-controlled study to assess the effectiveness of BiosLife in lowering serum LDL cholesterol and raising HDL cholesterol.
- Trial name
- NCT00457756
- Testing
- BiosLife Complete
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Utah
Xerostomia
Influence of Two Paraffin Wax Chewing Gums of Different Consistency on the Stimulated Saliva Flow Rate
The study examines two different chewing gums with regard to consistency and its influence on the result of sialometry
- Trial name
- NCT04661761
- Testing
- Paraffin Pellets from Aurosan GmbH, Chewing wax from the Saliva-Check Buffer from GC Europe
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hypersialorrhea (Excessive Salivation), Psychiatric Disorders
Chewing Gum as a Therapeutic Intervention for the Management of Hypersalivation
Psychiatric disorders often require specific treatments, usually involving medications called psychotropic drugs. While effective, these medications can cause significant side effects.
- Trial name
- Chew Daily (NCT07158359)
- Testing
- chewing gum mastication
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Cadillac
Type 2 Diabetes Mellitus
Prolactin Levels in Type 2 Diabetic Patients With Stage III Periodontitis
evaluate the role of prolactin hormone in the pathogenesis of periodontitis by assessing its local gingival levels and assess clinical parameters in patients who have type two diabetes
- Trial name
- prolactin (NCT06941246)
- Testing
- Non Surgical Periodontal Treatment, paper points, ELISA Kits
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Cognitive Dysfunction
Chewing Gum and Cognitive Function
This study is to investigate whether the improvement or maintenance of cognitive function is superior to the control group when gum chewing is performed in elderly people with subjective cognitive decline or mild cognitive…
- Trial name
- NCT05873023
- Testing
- Chewing gum
- Where
- 4 sites in South Korea
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Inha University Hospital
Postoperative Pain
Factors Influencing Postoperative Pain After Gingival Graft Harvesting
This prospective cohort study aims to evaluate patient-related, psychological, and clinical factors influencing postoperative pain following gingival graft harvesting from the palate.
- Trial name
- NCT07377370
- Testing
- Gingival graft harvesting from the palate
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Dental Plaque, Gingivitis
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of…
- Trial name
- NCT02366689
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Pulpitis, Pulpitis - Irreversible
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible…
- Conditions
- Pulpitis, Pulpitis - Irreversible, Pulp Inflammation, Healthy Pulp
- Trial name
- NCT06938191
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Pain, Postoperative, Gingival Diseases
Effect of Using Placental Membranes on Healing and Post-op Pain After Gum Surgery
When harvesting autogenous free grafts to treat periodontal conditions (e.g., lack of attached keratinized tissue, ridge defects, and other mucogingival deformities), the hard palate is the preferred donor site.
- Trial name
- NCT04957342
- Testing
- amnion-chorion membrane, Sutures
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Free Gingival Graft, Survey and Questionnaire
Free Gingival Graft Patients' Treatment Perception and Experience
Free gingival graft (FGG) is a common and effective periodontal procedure used to improve gum health; however, it can involve challenges such as postoperative pain and discomfort due to the requirement of a secondary donor site.
- Conditions
- Free Gingival Graft, Survey and Questionnaire, Postoperative Pain
- Trial name
- NCT07568327
- Testing
- Free Gingival Graft
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Periodontal Diseases, Smoking
The Effect of Scaling and Root Planing on Oral Inflammatory Biomarkers Among E-cig Users and Non-smokers
Background/Aim: There are no studies that have compared the gingival crevicular fluid (GCF) levels of IL-1β in non-smokers (NS) and electronic nicotine delivery system (ENDS)-users before and after scaling and root planing (SRP)…
- Trial name
- ENDS-SRP (NCT05745324)
- Testing
- Scaling and root planing
- Where
- Kuwait
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Plaque, Gingivitis
Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study
The objective of this randomized, single-center, examiner-blind, controlled, parallel group, six-month clinical study is to compare the antiplaque/antigingivitis potential of a no-alcohol essential oil containing mouthrinse and…
- Conditions
- Plaque, Gingivitis, Gum Inflammation, Bleeding
- Trial name
- NCT02980497
- Testing
- Listerine Zero Mouthwash (without alcohol), Listerine Antiseptic Mouthwash (with alcohol)
- Where
- Brazil
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dental Plaque and Gingivitis
The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
This is a six (6) month, double-blind, parallel, controlled clinical trial utilizing one hundred and sixty (160) adults to evaluate the reduction of dental plaque and gingivitis.
- Trial name
- NCT02243046
- Testing
- Control toothpaste, Experimental toothpaste, Active Comparator
- Where
- Dominican Republic
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis and Periodontal Diseases, Periodontitis
Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax
This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University…
- Trial name
- NCT07551115
- Testing
- Clinical Periodontal Evaluation, Microscopic Examination of Oral Protozoa
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Periodontitis, Gingivitis
Interleukin-38 Levels in Individuals With Periodontitis
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to receptors through various pathways and regulate the formation and function of inflammatory cytokines.
- Conditions
- Periodontitis, Gingivitis, Healthy
- Trial name
- NCT05568290
- Testing
- Saliva, gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Disease
Periodontal Disease and Circulatory Microbial Components
The goal of this project is to study the immune activity of certain proteins present in the blood of patients with severe periodontal disease. Periodontal disease (gum disease) is the major cause of tooth loss among adults.
- Trial name
- CirCo (NCT01154855)
- Testing
- Prophylaxis ; Gross debridement for diseased patients
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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