Clinical trials: Gingival Condition
Acne Vulgaris, Gingivitis and Periodontal Diseases
Retinoic Acid Therapy and Regulation of Salivary and Serum IL-1β, IL-8 and MCP-1 Levels
This prospective cohort study analysed the effects of systemic retinoic acid use on periodontal status, salivary flow rate (SFR), and salivary and serum levels of interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein…
- Conditions
- Acne Vulgaris, Gingivitis and Periodontal Diseases, Saliva Collection, Inflammation Biomarkers
- Trial name
- NCT06879795
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Gingivitis, Periodontitis
Circadian Clock Gene Expression in Periodontal Disease
This observational study aims to investigate whether periodontal inflammation is associated with alterations in the expression of circadian clock-related genes and proteins in gingival tissues.
- Trial name
- PERIOCLOCK (NCT07452783)
- Testing
- Gingival Tissue Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Gingival Recession
Assessment of The Accuracy of Complete Crown 3D Superimposition Technique Relative to The Gold Standard Technique for Digital Quantification of Volumetric Soft Tissue Changes in The Esthetic Zone
The aim of this study is to assess the precision of the complete crown technique employed for the superimposition of 3D models, specifically in the quantitative volumetric evaluation of gingival tissues.
- Trial name
- NCT06457672
- Testing
- Group I, Group II
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Gingival Recession
Comparison of Using Collagen Membrane and A-PRF Using VISTA Technique in Gingival Recession Treatment
To assess the efficacy of minimally invasive Vestibular Incision Subperiosteal Tunnel Access (VISTA) with collagen membrane and Advanced Platelet-rich Fibrin (A-PRF) in the treatment of multiple buccal gingival recession type…
- Trial name
- NCT06357351
- Testing
- vestibular incision sub periosteal tunnel access ( VISTA) technique.
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Gingival Overgrowth
Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox
Since the introduction of the lip repositioning procedure by a number of modifications to the technique have been introduced. All these modifications were made to prevent the main complication of lip repositioning surgeries…
- Trial name
- NCT04030767
- Testing
- Botox Injectable Product
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases, Gingivitis
The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases
A review of the literature revealed that while there are studies investigating the relationship between vitamin D and periodontal disease, there are no studies investigating the anti-inflammatory effect of vitamin D on…
- Conditions
- Periodontal Diseases, Gingivitis, Vitamin D Deficiency
- Trial name
- NCT07636733
- Testing
- Non-surgical periodontal treatment, Vitamin D administration, Oral Hygiene Education and Patient Motivation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Orthodontic Tooth Movement
Gingival Crevicular Fluid Cytokine Levels in Response to Orthodontic Forces
The aim of this randomized split-mouth study was to quantify simultaneously 30 analytes including cytokines, chemokines and growth factors in gingival crevicular fluid (GCF) in response to different magnitudes of forces during…
- Trial name
- GCF (NCT03555747)
- Testing
- Canine distalization
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Smoking, Chronic Periodontitis
Apoptotic Changes in Gingiva Caused by Smoking
Smoking is a major environmental risk factor associated with common forms of human chronic periodontitis. The aim of the present study was to evaluate apoptotic tissue alterations and tissue destruction in smoker and non-smoker…
- Trial name
- NCT03631498
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Gingivitis
Evaluation of Air Polishing With Ultrasonic Debridement in the Treatment of Initial Periodontal Pockets
Clinical evaluation of using erythritol powder as air polishing with ultrasonic scaling and root planing in the treatment of initial periodontal pockets.
- Trial name
- NCT03863093
- Testing
- Electro Medical Systems AIRFLOW®, Electro Medical Systems Piezo
- Where
- Syria
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Syrian Private University
Tooth Eruption Disorder
Digital Planning and Guided Dual Technique in Aesthetic Crown Lengthening
Excessive gingival exposure, commonly named gingival smile, results in a dentogingival disharmony. One of the gingival smile treatment is the aesthetics-related crown lengthening surgery (ACL) to provide a adequate clinical crown…
- Trial name
- NCT04922086
- Testing
- Conventional aesthetic crown lengthening surgery, Guided dual aesthetic crown lengthening surgery
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Alfenas
Wound Heal, Graft Pain
The Effectiveness of Different Methods for Healing a Palatal Donor Site
Postoperative complications associated with free gingival graft (FGG) procedures are prolonged bleeding from the donor site, postoperative pain and delayed wound healing which increases the patients' morbidity.
- Conditions
- Wound Heal, Graft Pain, Palate; Wound
- Trial name
- NCT03567148
- Testing
- PRF, Essix retainer, Ozone therapy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gazi University
Periodontal Diseases
TNF-α/HIF-1α/VEGF Pathway in Periodontal Diseases
This study aimed to investigate gingival crevicular fluid (GCF) and salivary hypoxia inducible factor-1 alpha (HIF-1α), vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) levels in different…
- Trial name
- NCT03558906
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Gingival Recession, Lack of Keratinized Gingiva
A Comparison of Side Access Mucosal Releasing Incision (SAMRI) and Sulcular Tunnel Access to Treat Gingival Recession.
This study will compare two incision designs to allow for coronal gingival/mucosal flap advancement and tissue augmentation with acellular dermal matrix (ADM) graft around teeth with gingival recession and a lack of adequate…
- Trial name
- NCT04179448
- Testing
- SAMRI, STA
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gingivitis, Plaque, Dental
Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash
Qualified subjects will be enrolled and randomized to either one of the two study groups described above based on their initial modified gingivitis and plaque scores.
- Trial name
- NCT07263698
- Testing
- cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Recession, Connective Tissue Defect
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Periodontal health and preservation of the dentition without tooth loss are important quality of life components and should be safeguarded in order to provide optimal function and esthetics.
- Trial name
- FibroGide (NCT07437417)
- Testing
- Volume stable collagen matrix, Control
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dental Plaque, Gingivitis
Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)
The objective of this clinical research study is to assess the efficacy of a commercially available triclosan/copolymer toothpaste compared to a commercially available oral hygiene multi-component regimen encompassing the use of…
- Trial name
- NCT02366689
- Testing
- Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Caries, Dental, Gingivitis
Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits
An epidemiological survey for prevalence description of dental morbidity (caries, gingivitis, dental trauma and fluorosis) among Israel Defense Forces (IDF) general recruits.
- Conditions
- Caries, Dental, Gingivitis, Fluorosis, Dental Trauma
- Trial name
- NCT02958891
- Testing
- Data collection
- Where
- Israel
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Periodontitis, Gingivitis
Interleukin-38 Levels in Individuals With Periodontitis
Interleukin (IL)-38 is the newest member of the IL-1 family. It can bind to receptors through various pathways and regulate the formation and function of inflammatory cytokines.
- Conditions
- Periodontitis, Gingivitis, Healthy
- Trial name
- NCT05568290
- Testing
- Saliva, gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Gingivitis, Periodontal Disease
Rapid Point-of-Care Salivary Diagnostic for Periodontal Health
The purpose of this study is to learn if a chair-side testing device will accurately measure levels of a salivary biomarker and thus indicate if a patient has periodontal health, gingivitis or periodontal disease.
- Trial name
- NCT02403297
- Testing
- Quik Check PD
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Innovative Diagnostics Inc
Gingivitis, Periodontitis
OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study.
Periodontal disease- Inflammatory, Multifactorial, and Threshold disease. Periodontal disease is a highly prevalent dental disease, an almost 100% prevalence in developing countries.
- Conditions
- Gingivitis, Periodontitis, Aerosol Disease, Gingival Disease
- Trial name
- NCT03839719
- Testing
- Group PI, Group OC, Group CHX
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College of Dentistry, Indore
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