Clinical trials: Glial Fibrillary Acidic Protein
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Multiple Sclerosis, NMO Spectrum Disorder
China National Registry of Neuro-Inflammatory Diseases
Central nervous system (CNS) idiopathic inflammatory demyelinating diseases (IDD) are mainly diseases caused by autoimmune factors that result in CNS demyelination damage and loss.
- Conditions
- Multiple Sclerosis, NMO Spectrum Disorder, Clinically Isolated Syndrome, CNS Demyelinating Autoimmune Diseases
- Trial name
- CNRID (NCT05154370)
- Testing
- Intravenous steroid
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Tiantan Hospital
Dexmedetomidine
Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in…
- Trial name
- NCT03234660
- Testing
- Dexmedetomidine Hydrochloride, control
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Sleep Apnea, Obstructive
Biological and Cognitive Marker of Neurodegeneration in Obstructive Sleep Apnea Patients
The goal of this observational study is to investigate biomarkers and neurocognitive markers of neurodegenerative processes in obstructive sleep apnea patients.
- Trial name
- NCT06167369
- Where
- Germany
- Volunteers
- 136 people
- Sponsor
- Technische Universität Dresden
Pediatric Traumatic Brain Injury
Validating a Blood Test for the Detection of Traumatic Brain Injury in Children
The primary objective of this study is to establish if Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) are predictive of computed tomography (CT) findings in pediatric traumatic brain…
- Trial name
- NCT06940232
- Testing
- Blood Test for Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acute Biomarkers
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of Nebraska
Head Injury Trauma, Traumatic Brain Injury, Mild
The PIONEER Comparative Effectiveness Study - Project 2
This is a pragmatic, open-label, multicenter, stepped-wedge, Type II hybrid effectiveness-implementation study. It is designed to evaluate both the comparative effectiveness and implementation feasibility of a…
- Trial name
- NCT07829107
- Testing
- Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only
- Where
- 6 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Michigan
Acute Stroke
Direct-to-angio Approach From loCal hOspitals Based on a PoInt-of-care bLOod Test for LVO
Direct-to-angio approach from loCal hOspitals based on a PoInt-of-care bLOod Test for LVO (COPILOT) is a multi-center, prospective, cluster-randomized crossover trial that will evaluate if the triage assessment to thrombectomy…
- Trial name
- COPILOT (NCT06910163)
- Testing
- Diagnostic standard of care, LVOne Test
- Where
- Puerto Rico
- Volunteers
- 520 people
- Sponsor
- Juan Vicenty
Donor Site Complication, Delirium
s100β, NSE n GFAP in Living Donor Hepatectomy and Delirium
The post-operative delirium picture is a serious and common complication seen after any major surgery, including hepatic resection.
- Conditions
- Donor Site Complication, Delirium, Uremic Encephalopathy, Neurologic Manifestations
- Trial name
- NCT04422925
- Testing
- Living Donor Hepatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Multiple Sclerosis
Serum Neurofilament-light Chain and GFAP Levels in Patients From the OFSEP Cohort at Different Landmarks of Multiple Sclerosis
The investigators hypothesize that serum neurofilament-light chain (NfL) levels can provide information about the level of activity and progression of Multiple Sclerosis at different stages and landmarks of the disease.
- Trial name
- NeurofilMS (NCT03981003)
- Testing
- Blood sample
- Where
- 28 sites in France, Martinique
- Volunteers
- 1,150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mild Traumatic Brain Injury
VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)
Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured.
- Trial name
- NCT06449183
- Testing
- VIDAS® TBI Test [GFAP and UCH-L1 assays]
- Where
- 5 sites in United States
- Volunteers
- 903 people
- Sponsor
- BioMérieux
Subarachnoid Haemorrhage (SAH)
Serum GFAP and UCHL1: Evaluation of Their Predictive Value for SAH
To verify the analytical performance of GFAP and UCH-L1 biomarkers marketed by Abbott Diagnostics and to assess diagnostic accuracy of these biomarkers in predicting subarachnoid haemorrhage
- Trial name
- SAH (NCT06581757)
- Where
- United Kingdom
- Volunteers
- 144 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Kidney Transplant; Complications, Neurologic Manifestations
Evaluation of s100β, NSE and GFAP Levels in Renal Transplantation
Uremic encephalopathy is an organic brain disorder may be frequently seen in patients with acute or chronic renal failure. Certain neurological symptoms can be found under clinical glomerular filtration rate of 15 ml/minutes.
- Conditions
- Kidney Transplant; Complications, Neurologic Manifestations, Uremic Encephalopathy
- Trial name
- NCT04042272
- Testing
- S100β, Neuron specific enolase (NSE) and Glial fibrillary acidic protein (GFAP)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Traumatic Brain INjury
Prognostic Potential of Prehospital Biomarkers in TBI Patients
The PreTBI III study aims to investigate the prognostic potential of prehospital and repeated in-hospital S100B, NSE and GFAP measurements as predictors of neurological outcome in patients suffering severe TBI.
- Trial name
- PreTBI III (NCT03062566)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- University of Aarhus
Amyotrophic Lateral Sclerosis (ALS), Neurodegenerative Disorders
Serum Neurofilaments in the Diagnosis of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease, often difficult to diagnose due to symptoms similar to other neurological pathologies.
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Neurodegenerative Disorders, Motor Neuron Diseases
- Trial name
- DIAGONALS (NCT07706270)
- Testing
- Serum Neurofilament Serum NfL Measurement
- Volunteers
- 138 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury.
- Trial name
- GUEST (NCT05885529)
- Testing
- UCH-L1 GFAP
- Where
- 15 sites in France, Monaco
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Princesse Grace
Concussion, Mild
Rapid, Accurate, Cost-effective Assessment of Blood Biomarkers for Diagnosis of Concussion
The goal of this observational study is to test if a biosensor can accurately measure a blood biomarker in adult patients presenting to the emergency department with concussion.
- Trial name
- RACE (NCT05588115)
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University of Calgary
NMOSD
Clinical Study to Evaluate the Effects of the Complement C5 Inhibitor Ravulizumab on Serum Neurofilament Light Chain (sNfL) and Glial Fibrillary Acidic Protein (sGFAP) Levels in Patients With Aquaporin-4-Positive (AQP4-Ab+) Neuromyelitis Optica Spectrum Disorder (NMOSD)
This is a nationwide observational study looking at how ravulizumab, a complement C5 inhibitor, affects blood biomarkers o sNfL and sGFAP in people with AQP4-antibody positive NMOSD.
- Trial name
- NCT06903130
- Testing
- Blood samples for sNfL and sGFAP levels
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- National and Kapodistrian University of Athens
Stroke Code, Large Vessel Occlusion
Evaluation of a Point-of-care Lateral Flow Assay in Glial Fibrillary Acidic Protein (GFAP) and D-dimer in Diagnosis of Large Vessel Occlusion Acute Ischemic Stroke in a Pediatric Hospital
The goal of this study is to test the efficacy of a rapid bedside blood test in determining if a stroke is happening in children who present to the emergency department with stroke symptoms.
- Conditions
- Stroke Code, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- NCT07474675
- Testing
- Point of Care Rapid Assay
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Neurofilament Light Chain, Glial Fibrillary Acidic Protein
Analysis of NfL and GFAP in Different Dietary Patterns
This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.
- Conditions
- Neurofilament Light Chain, Glial Fibrillary Acidic Protein, GFAP, Vegan Diet
- Trial name
- NCT07312994
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Multiple Sclerosis, Exercise
Impact of Exercise Training on Serum Glial Fibrillary Acidic Protein (GFAP), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis
This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period.
- Conditions
- Multiple Sclerosis, Exercise, Function
- Trial name
- NCT07521995
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University