Clinical trials: Guillain Barré Syndrome
Myasthenia Gravis, Guillain-Barre Syndrome
Ventilator Weaning Practices in Patients Intubated for Guillain-Barré Syndrome or Myasthenia Gravis
Guillain-Barré syndrome and myasthenia gravis are two neuromuscular diseases that are commonly managed in ICUs that may require different weaning protocols.
- Trial name
- GUIMAUVE (NCT07022028)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Poitiers University Hospital
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes.
- Conditions
- Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Peripheral Nerve Disorder, Peripheral Nerves US
- Trial name
- NCT06615622
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Guillain-Barre Syndrome
Mini-pool Intravenous Immunoglobulin (MP-IVIG) in Guillain-Barré Syndrome
1. study the pharmacokinetics of mini-pooled intravenous immunoglobulin( MP-IVIG) 2. to determine the efficacy of intravenous immunoglobulin (IVIg) in hastening recovery and reducing the complications of Guillain-Barré syndrome…
- Trial name
- NCT04550611
- Testing
- Mini-pool Intravenous Immunoglobulin (MP-IVIG), plasma exchange
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Guillain Barré Syndrome
Exoskeleton Gait Training in Guillain-Barré Syndrome: Safety, Feasibility, Usability, and Longitudinal Outcomes
The main objective of the study is to determine if the Atalante X exoskeleton by Wandercraft is a safe, reliable, and usable device for people with Guillain-Barré Syndrome (GBS) who are unable to walk.
- Trial name
- Atalante GBS (NCT07556809)
- Testing
- Exoskeleton Wandercraft Atalante X, usability and gait rehabilitation
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Institut Guttmann
Tetraplegia, Respiratory Failure
Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome.
To estimate, in a longitudinal and not invasive way, in patients with SGB at respiratory risk, the function of respiratory muscles and that of the upper airways muscles by investigating the force of the tongue, the gulp, and the…
- Trial name
- DGVSB (NCT01024088)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Guillain-Barré Syndrome, Miller Fisher Syndrome
International Guillain-Barré Syndrome Outcome Study
International GBS Outcome Study (IGOS) is a study conducted by the members of the Inflammatory Neuropathy Consortium (INC) and Peripheral Nerve Society (PNS) on disease course and outcome in Guillain-Barré syndrome (GBS).
- Trial name
- IGOS (NCT01582763)
- Where
- 138 sites in United States, Argentina and 19 more
- Volunteers
- 2,000 people
- Sponsor
- Erasmus Medical Center
Guillain-Barré Syndrome
Efficacy and Safety of Efgartigimod in the Treatment of Guillain-Barré Syndrome(GREAT)
The goal of this clinical trial is to evaluate the safety and effectiveness of Efgartigimod in patients with Guillain-Barre syndrome (GBS).
- Trial name
- GREAT (NCT07806916)
- Testing
- Intravenous immunoglobulin (IVIG), Efgartigimod Alfa-Fcab
- Volunteers
- 110 people
- Sponsor
- Beijing Tiantan Hospital
Guillain-Barre Syndrome, Constipation
Gastrointestinal Transit Time in Patients With Guillain-Barré Syndrome
Constipation is a common condition among patients with Guillain-Barré Syndrome. It is believed, that the constipation is caused by autonomic neuropathy.
- Trial name
- NCT02459808
- Where
- Denmark
- Sponsor
- University of Aarhus
Guillain Barré Syndrome
Effect of PNF + Core Strengthening Exercise in Sub-acute Guillain Barre Syndrome
This randomized controlled trial will evaluate the effectiveness of proprioceptive neuromuscular facilitation combined with core strengthening exercises in Guillain barre syndrome patients on balance, strength and ADLS.
- Trial name
- PNF-CORE-GBS (NCT07745556)
- Testing
- Proprioceptive neuromuscular facilitation combined with core strengthening exercise, conventional physiotherapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Rida
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
Guillain-Barré Syndrome
Phase III Clinical Trial of NPB-01 in Patients With Guillain-Barré Syndrome
Patients diagnosed with Guillain-Barré syndrome were confirmed based on the diagnostic criteria for Guillain-Barré syndrome. Patients who meet all inclusion criteria and do not conflict with the exclusion criteria will receive…
- Trial name
- NCT02221271
- Testing
- NPB-01
- Where
- Japan
- Volunteers
- 22 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Guillain-Barre Syndrome
Safety Study of GBS Following Menactra Meningococcal Vaccination
We are conducting a large, record-based study to assess the risk of Guillain-Barré Syndrome (GBS), a serious demyelinating disease, following immunization with the tetravalent meningococcal conjugate vaccine (Menactra) that is…
- Trial name
- NCT00575653
- Where
- 6 sites in United States
- Volunteers
- 6,000,000 people
- Sponsor
- Harvard Pilgrim Health Care
Guillain-Barre Syndrome
Noninvasive Support for Acute Respiratory Failure in Guillain-Barré Syndrome
This study will involve 70 adult patients with Guillain-Barré syndrome who have severe breathing problems. It will compare two types of breathing support: high-velocity nasal cannula (HVNC) (which delivers heated and humidified…
- Trial name
- NCT06996509
- Testing
- Non-Invasive Ventilation (NIV), High Velocity Nasal Insufflation
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Myocardial Dysfunction, Guillain-Barre Syndrome
Myocardial Changes in Pediatric Guillain-Barré Syndrome
This prospective cohort study aims to identify and characterize cardiac changes including electrocardiographic, echocardiographic, and biochemical abnormalities in pediatric patients with Guillain-Barré syndrome.
- Trial name
- NCT07842705
- Volunteers
- 72 people
- Sponsor
- Assiut University
Guillain-Barré Syndrome (GBS)
A Study of Empasiprubart as Add-On Therapy to IVIg in Adult Participants With Guillain-Barré Syndrome
The main purpose of this study is to learn whether empasiprubart, when given in addition to intravenous immunoglobulin (IVIg), helps adults with Guillain-Barré syndrome (GBS) recover and whether it is safe.
- Trial name
- embridge (NCT07821762)
- Testing
- Empasiprubart IV, Intravenous immunoglobulin (IVIg)
- Volunteers
- 63 people
- Sponsor
- argenx
Guillain-Barré Syndrome
RehabGBs: Rehabilitation in People With Guillain-Barré Syndrome
Guillain-Barré syndrome (GBS) is a neurological disease characterized by an inflammation of peripheral nerves, which might be responsible for long-term disability.
- Trial name
- RehabGBs (NCT05461898)
- Testing
- Inpatient Rehabilitation, Inspiratory muscle training
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Centro de Reabilitacao do Norte
Inclusion Body Myositis, Myotonic Dystrophy 1
The Use of Assistive Gait Devices Can Reduce the Risk of Falls in Patients With Neuromuscular Diseases Following a Training Period.
The planned project is an intervention study to assess the risk of falling after adaptation of an assistive gait devices in patients with the following neuromuscular diseases: Inclusion body myositis, myotonic dystrophy, limb…
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy 1, Myotonic Dystrophy 2, Facio-Scapulo-Humeral Dystrophy
- Trial name
- Risk of fall (NCT07072676)
- Testing
- Assistive gait devices combined with physiotherapy
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- LMU Klinikum
Myositis, Myasthaenia Gravis
Neuromuscular Complications of MEK Inhibitors: a French Case Series and a Systematic Review of the Literature
MEK inhibitors (trametinib, cobimetinib, selumetinib or binimetinib) have been used since 2016 to treat metastatic melanoma, by targeting the MAPK pathway Neuromuscular complications (neuropathy, myasthenia or myositis) have been…
- Conditions
- Myositis, Myasthaenia Gravis, Neuropathy, Guillain Barré Syndrome
- Trial name
- NCT06740656
- Testing
- No Interventions
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Central Hospital, Nancy, France
Guillain-Barré Syndrome
A Clinical Trial of CK0801 (a New Drug) In Patients With Treatment-Resistant Guillain-Barré Syndrome (GBS)
The goal of this research study is to determine whether it is safe and practical to give CK0801 (a cord-blood derived T-regulatory cell product) to patients with Guillain-Barré Syndrome (GBS).
- Trial name
- NCT03773328
- Testing
- CK0801
- Sponsor
- Cellenkos, Inc.