Clinical trials: Gum Disease
Post COVID-19 Condition
Periodontal Health in Post COVID-19 Patients
The aim of this study is; To Assess the association between periodontal health and Matrix metalloproteinase-8 (MMP-8) level in Gingival Crevicular Fluid (GCF) in post COVID-19 patients.
- Trial name
- NCT05950230
- Testing
- Assess Periodontal Health Status, Collecte GCF samples by paperstrip
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Tooth Loss, Partial Edentulism in the Maxilla or in the Mandible
Evaluation of Autogenous Bone Graft on Immediate Dental Implant Osseointegration Using Piezosurgery
This clinical study aims to evaluate the clinical and radiographic outcomes of immediate dental implant placement in mandibular premolar sites.
- Trial name
- ABG-IDIP (NCT07705399)
- Testing
- Immediate implant with autogenous bone graft, Immediate implant without bone graft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Tobacco Dependence
Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment
To evaluate the safety, smoking cessation and reduction rate during 3 months of active nicotine replacement therapy (NRT) and a follow-up period of 3 months in smoking hospital physicians and staff who are motivated to quit
- Trial name
- NCT00749463
- Testing
- Nicotine Gum, Nicotine Patch
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- McNeil AB
Periodontitis
Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis
Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens.
- Trial name
- PerioFPS (NCT07070453)
- Testing
- Non-surgical periodontal treatment, Scaling and root planing + aPDT
- Where
- 2 sites in Portugal
- Volunteers
- 20 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Healing Surgical Wounds, Periodontitis
Modified Vertical Internal Mattress Suture Versus Simple Loop Interrupted Suture.
Aim of study was clinical comparative evaluation of using modified vertical internal mattress suturing technique and simple loop interrupted suturing technique in the outcome of modified Widman flap surgery for the management of…
- Trial name
- NCT03556163
- Testing
- Modified vertical internal mattress sutures + MWF surgery., Simple loop interrupted sutures + MWF surgery.
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingival Recession
Two Techniques for Root Coverage With a Xenogeneic Collagen Matrix
Gingival recessions are often successfully treated by coronally advanced flap technique (CAF) associated with subepithelial connective tissue grafts (SCTG).
- Trial name
- NCT02129504
- Testing
- root coverage comparing two techniques
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Plaque, Dental
Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva
This 4-week clinical study was designed to examine the antibacterial efficacy of brushing with a 0.454% stannous fluoride toothpaste with potassium nitrate and pyrophosphate compared to a toothpaste containing 0.76% MFP (marketed…
- Trial name
- NCT06353165
- Testing
- Stannous fluoride toothpaste, Colgate Dental Cream
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontitis, Diabete Mellitus
Omega-3 Pufa and Aspirin as Adjunctive Therapy in Treatment of Smoker Patients With Stage Iii Periodontitis
Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without…
- Trial name
- NCT07385300
- Testing
- Omega-3 PUFA and Aspirin as adjunctive therapy to (SRP), Omega-3 PUFA and Aspirin and doxycycline as adjunctive therapy to (SRP), scaling and root planning (SRP)
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Alexandria University
Periimplantitis
Evaluation of the Effects of the Low-level Laser Therapy as an Adjunct to Nonsurgical Treatment in Patients With Periimplantitis
The main objective of this study is to evaluate the clinical efficacy of low-level laser therapy (LLLT) in addition to non-surgical periodontal treatment in patients with peri-implantitis.
- Trial name
- NCT07128134
- Testing
- Low Level Laser Therapy, Non-surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Mustafa Kemal University
Tooth Loss, Surface Treatment
Effect of Different Loading Protocols on Photofunctionalized Implants in the Posterior Maxilla
This randomized clinical trial evaluates different loading protocols for UV-photofunctionalized dental implants in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow
- Conditions
- Tooth Loss, Surface Treatment, Immediate Dental Implant Loading, Implant Loading
- Trial name
- PHOTOLOAD (NCT07700914)
- Testing
- Immediate loading of UV-photofunctionalized dental implants, Early loading of UV-photofunctionalized dental implants, Conventional loading of UV-photofunctionalized dental implants
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Orthodontic Tooth Movement
Gingival Crevicular Fluid Cytokine Levels in Response to Orthodontic Forces
The aim of this randomized split-mouth study was to quantify simultaneously 30 analytes including cytokines, chemokines and growth factors in gingival crevicular fluid (GCF) in response to different magnitudes of forces during…
- Trial name
- GCF (NCT03555747)
- Testing
- Canine distalization
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontal Diseases
Effect of Internal and External Micro-needling in Treatment of Stage III Periodontitis
Periodontitis is a dysbiotic disease characterized by the destruction of the periodontium (alveolar bone, cementum, periodontal ligament, gingiva) and considered the main cause of tooth loss which is linked to a change in the…
- Trial name
- NCT06578403
- Testing
- external microneedling, minimally invasive non- surgical periodontal therapy, internal micro_needling
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Chronic Periaortitis, Intrabony Periodontal Defect
Atorvastatin as an Adjunct to DFDBA in Intrabony Defects
Periodontitis is a major oral health problem which leads to the progressive destruction of periodontal ligament and alveolar bone with pocket formation, recession or both.
- Trial name
- NCT03009097
- Testing
- DFDBA, DFDBA with atorvastatin
- Volunteers
- 26 people
- Sponsor
- Kamineni Institute of Dental Sciences
Gingival Recession
A New Therapeutic Approach for Root Coverage
Different surgical techniques have been proposed for root coverage, showing varying results especially in areas of deep recessions.
- Trial name
- NCT01143610
- Testing
- Newly forming bone technique for root coverage, Subepithelial connective tissue graft for root coverage.
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peri-Implantitis, Peri-implant Mucositis
Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Implant Infection, Dental Implant Failed
- Trial name
- NCT05024760
- Testing
- Chlorhexidine, Hydrogen Peroxide
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Madigan Army Medical Center
Periodontitis, Arthritis, Rheumatoid
Rheumatoid Arthritis and Treatment of Periodontitis: a Randomized Clinical Trial.
Periodontitis is an infectious disease defined by bacteria-mediated inflammation of the supporting tissues of the teeth that if left untreated may ultimately lead to the destruction of the attachment apparatus, culminating in…
- Trial name
- NCT05271890
- Testing
- Immediate non-surgical periodontal treatment and oral hygiene instructions
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pisa
Periodontitis
Air Polishing as an Adjunct in Non-surgical Periodontal Therapy
Periodontal disease is an infection that causes inflammation and destruction of the tooth supporting structures, and if untreated, will eventually lead to tooth loss.
- Trial name
- NCT04178291
- Testing
- Ultrasonic scaler and Gracey currettes, Air polishing with erythritol powder
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Gingival Recession
Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects
This study deals with coverage of multiple denuded roots. The current standard treatment requires surgical correction and uses soft tissue taken from the roof of the mouth to enhance results.
- Trial name
- NCT01440426
- Testing
- Autologous connective tissue graft with rotated papilla flap, Collagen matrix construct (Mucograft)
- Where
- 13 sites in Belgium, Germany and 4 more
- Volunteers
- 187 people
- Sponsor
- Maurizio Tonetti
Periodontal Disease; Gingivitis; Dental Plaque; Malocclusion (Post-orthodontic Treatment)
Digital vs Conventional VFR in Post-Orthodontic Retention
This study is comparing two ways of making a retainer, the clear, removable kind worn after braces to see whether the way it's made affects gum health.
- Trial name
- NCT07760935
- Testing
- Digital Vacuum-Formed Retainer, Conventional Vacuum-Formed Retainer
- Volunteers
- 52 people
- Sponsor
- Ziauddin University