Clinical trials: HIV Infection Primary
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Quality of Health Care, HIV/AIDS
Using Electronic Medical Record Data to Improve HIV Primary Care
This cluster randomized control trial examines whether an audit and feedback study improves care of patients living with HIV/AIDS in a family health team setting.
- Conditions
- Quality of Health Care, HIV/AIDS, Electronic Health Records
- Trial name
- NCT04107233
- Testing
- Audit and Feedback
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV Infections, Sexually Transmitted Diseases
Parents Matter!: Interventions to Promote Effective Parent-Child Communication
Parents Matter is a community-based project whose goal it is to develop and test an intervention designed to promote effective parent-child communication about sexuality in order to promote sexual health among adolescents.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Pregnancy
- Trial name
- NCT00137943
- Testing
- Full Parent communication intervention, Brief Parent Communication Intervention, Control Parent Intervention
- Where
- 3 sites in United States
- Volunteers
- 2,210 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV/AIDS, Tuberculosis
Comparison of Door-to-door Versus Community Gathering to Provide HIV Counseling and Testing Services in Rural Lesotho
The purpose of this trial is to determine if door-to-door is more effective than community gathering in providing voluntary HIV counseling and testing (VCT) in communities in rural Lesotho.
- Conditions
- HIV/AIDS, Tuberculosis, Diabetes Mellitus, Arterial Hypertension
- Trial name
- DoDoPi (NCT01459120)
- Testing
- Door-to-door, Pitso
- Where
- 2 sites in Lesotho
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- SolidarMed
HIV Infections
Love Infection: A Dramatized Story Intervention (Telenovela/Soap Opera) for HIV Prevention
Purpose: To test the feasibility, acceptability of the IA intervention (four telenovela episodes), assessment of the mechanisms of action (self-efficacy, narrative engagement, and emotional elicitation) and conduct a randomized…
- Trial name
- IA (NCT05358366)
- Testing
- Infeccion de Amor (Love Infection)
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Hiv
Engaging Men Through HIV Self-Testing With Differentiated Care to Improve ART Initiation and Viral Suppression Among Men in Malawi
Men in sub-Saharan Africa who test HIV-positive continue to have poor ART initiation and retention outcomes. The proposed project will test a home-based ART intervention for men who are living with HIV compared to facility-based…
- Trial name
- NCT04858243
- Testing
- Home-Based ART, Facility-Based ART
- Where
- Malawi
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
This is a randomized controlled trial to test a combination behavioral and biomedical interventions to improve the HIV prevention and care cascades in a population of mobile men in a high priority setting (fishermen in Kenya).
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, HIV Infections, Sexually Transmitted Diseases, Viral
- Trial name
- NCT04772469
- Testing
- Provision of multiple self-tests, Small monetary incentives, Use of SMS/text reminders to motivate adherence to ART or PrEP
- Where
- Kenya
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PrEP, HIV Prevention Program
Academic Detailing to Optimize PrEP Implementation in Pediatric Primary Care Settings: ADOPT-PrEP
In this study, 50 pediatricians will participate in academic detailing, an evidence-based, 1-on-1 outreach education technique intended to promote clinician behavior change through brief, highly interactive, and individualized…
- Trial name
- ADOPT-PrEP (NCT06804382)
- Testing
- Academic detailing
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pregnancy, HIV
Management and Optimization of Nutrition, Antenatal, Reproductive, Child Health & HIV Care
This study evaluates the impact of a quality improvement (QI) intervention on maternal and child healthcare services in seven primary healthcare (PHC) clinics, in a rural setting of KwaZulu-Natal, South Africa.
- Trial name
- MONARCH (NCT02626351)
- Testing
- Quality Improvement, Baseline data collection (active comparator)
- Where
- South Africa
- Volunteers
- 3,172 people, healthy volunteers welcome
- Sponsor
- University of KwaZulu
HIV Infections, HIV Primary Infection
A Couples-based Intervention for Transgender Women and Their Partners
This project seeks to test the efficacy of a couples-based HIV prevention program in large-scale randomized controlled trial (RCT) to reduce HIV risk among transgender woman and their partners.
- Trial name
- T2 (NCT04067661)
- Testing
- CHIP, Control
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Human Immunodeficiency Virus Transmission
PC4PrEP: Integrating PrEP Into Primary Care
Oral pre-exposure prophylaxis (PrEP) has been proven effective in reducing HIV infection in high-risk men who have sex with men, heterosexually active women and men, and injecting drug users.
- Trial name
- PC4PrEP (NCT03617874)
- Testing
- PC4PrEP- Intervention Clinics, Standard of Care Clinics
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
HIV Infection Primary
Assessing Differential Adherence to Medications and Quality of Life Among People Living With HIV and Comorbidities
The investigators propose to utilize quantitative and qualitative methodology to better understand the impact of multiple drug use (polypharmacy) on medication adherence as well as the driving forces behind differential adherence…
- Trial name
- TEAMH (NCT03387397)
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Northwell Health
HIV/AIDS and Infections, Drug Abuse
A Community-University Approach to Preventing HIV
Examine the feasibility and acceptability of delivering the S4E intervention to 20 African-American youths between the ages 16-21 in Flint, Michigan.
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03938077
- Testing
- Storytelling 4 Empowerment
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
HIV Seropositivity
A Multilevel, Multiphase Optimization Strategy for PrEP (MOST:PrEP)
What is known: There are 1.2 million people in the US who meet the indications for PrEP; yet, disparities exist in uptake. For example, only 9% of Black and 16% of Latino individuals, compared to 65% of White individuals, have…
- Trial name
- MOST:PrEP (NCT06334341)
- Testing
- Computer-based simulation training for providers, Best Practice Alert, HIV Risk Assessment
- Where
- United States
- Volunteers
- 1,380 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Infections, Streptococcal
Primary and Booster Vaccination Study With a Pneumococcal Vaccine in HIV Infected, HIV Exposed Uninfected and HIV Uninfected Children 6 to 10 Weeks of Age.
The purposes of this study: To evaluate the immunogenicity, safety and reactogenicity of pneumococcal vaccine GSK1024850A in HIV infected infants, HIV exposed uninfected infants and HIV unexposed uninfected infants following a…
- Trial name
- NCT00829010
- Testing
- Pneumococcal vaccine GSK1024850A, Tritanrix-HepB/Hib, measles
- Where
- South Africa
- Volunteers
- 489 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pre-Exposure Prophylaxis, Hiv
Peer-led Social Media Intervention to Prevent HIV Among Young Men Who Have Sex With Men (YMSM)
The aim of this study is to examine the effect of social media intervention on the use of pre-exposure prophylaxis (PrEP) by young men who have sex with men (YMSM) in the greater New Haven area.
- Conditions
- Pre-Exposure Prophylaxis, Hiv, Men
- Trial name
- NCT04417946
- Testing
- PrEP messages, Heath messages
- Where
- 2 sites in United States
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Yale University
Acceptability of Health Care, HIV Primary Infection
A Multicomponent Intervention to Address Gender-based Violence in HIV
This project seeks to adapt and pilot a trauma-informed combination intervention named 'Kickin' it with the Gurlz' that was designed with, for, and by transgender women of color to improve HIV prevention continuum outcomes.
- Trial name
- NCT04799197
- Testing
- Kicking it with the Gurlz
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sexually Transmitted Diseases, HIV
Effectiveness of HIV Risk Reduction Program Among African American Men
This study will test the effectiveness of a brief clinic-based program designed to promote the correct use of condoms among young African-American men newly diagnosed with a sexually transmitted disease.
- Trial name
- NCT00314028
- Testing
- Focus on the Future, Control standard of care treatment
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Richard Crosby
HIV Infections, Cancer, Second Primary
Micronutrient Supplemented Probiotic Yogurt for HIV/AIDS and Other Immunodeficiencies
We hypothesize that micronutrient fortified probiotic yogurt can improve nutritional status and enhance immunity parameters in subjects HIV/AIDS and other immunodeficiencies.
- Trial name
- NCT00517803
- Testing
- Probiotic Yogurt B: with various micronutrients, Probiotic Yogurt A: Kaiser micronutrients, Probiotic yogurt C: with basic micronutrients
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
HIV Infections
Impact of a Telenovela/Soap Opera for HIV Prevention in Latinas
Latinas continue to be affected disproportionally by HIV in the United States (US). Often, Latinas are not aware of their HIV status.
- Trial name
- NCT05929482
- Testing
- Infección de Amor (Infectious Love)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill