Clinical trials: Haematological Malignancies
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COVID, Oncology
Remote Monitoring of Cancer Patients With Suspected Covid-19
Since emerging in December 2019, coronavirus disease 2019 (Covid-19) has developed into an unprecedented global pandemic. The causative pathogen, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential…
- Conditions
- COVID, Oncology, Haematological Malignancy
- Trial name
- RECAP (NCT04397705)
- Testing
- Patient Status Engine
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- The Christie NHS Foundation Trust
Hematological Malignancies Treated With Intensive Chemotherapy
Evolution of Thromboelastography During Tranexamic Acid Treatment
Patients with hematological malignancies are at increased risk of bleeding, especially during intensive chemotherapy. The aim of this study is to compare by thromboelastography changes during the intensive chemotherapy in…
- Trial name
- TTRAP-Bleeding (NCT03801122)
- Testing
- Tranexamic acid
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diffuse Large B Cell Lymphoma
Acalabrutinib in Combination With R-CHOP for Previously Untreated Diffuse Large B-cell Lymphoma (DLBCL)
This study evaluates the addition of Acalabrutinib to current standard therapy of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (R-CHOP) for patients with previously untreated CD20 positive Diffuse Large…
- Trial name
- REMoDL-A (NCT04546620)
- Testing
- R-CHOP, R-CHOP + acalabrutinib
- Where
- 33 sites in United Kingdom
- Volunteers
- 453 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child
Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant
This study will evaluate pediatric patients with malignant or non-malignant blood cell disorders who are having a blood stem cell transplant depleted of T cell receptor (TCR) alfa and beta cells that comes from a partially…
- Conditions
- Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child, Lymphoma, Non-Hodgkin, Myelodysplastic Syndrome
- Trial name
- NCT02065869
- Testing
- BPX-501 T cells, Rimiducid
- Where
- 4 sites in Italy, United Kingdom
- Volunteers
- 187 people
- Sponsor
- Bellicum Pharmaceuticals
Haematological Malignancy, Acute Leukemia
A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults Requiring Hematopoietic Stem Cell Allografts
To date, allogeneic haematopoietic stem cell transplantation (aHSCT) is the only curative treatment for many paediatric and young adult haematological pathologies (acute leukaemia, myelodysplastic syndromes, haemoglobinopathies…
- Conditions
- Haematological Malignancy, Acute Leukemia, Myelodysplastic Syndromes, Hemoglobinopathy in Children
- Trial name
- EVAADE (NCT04331483)
- Testing
- Physical activity program
- Where
- France
- Sponsor
- Centre Leon Berard
Haematological Malignancy
Economic Evaluation of Innovative Molecular Analyses in Onco-haematology
To evaluate the impact of innovative molecular diagnostics on the clinical management of patients with haematological malignancies via updated Appropriate-Prescribing-Guides including Next-Generation Sequencing (NGS) panels…
- Trial name
- NCT03750994
- Where
- 26 sites in France
- Volunteers
- 3,960 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Colorectal Cancer
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies
This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.
- Conditions
- Breast Cancer, Colorectal Cancer, Adenoid Cystic Carcinoma, Non-hodgkin Lymphoma
- Trial name
- NCT03422679
- Testing
- CB-103
- Where
- 17 sites in United States, France and 4 more
- Volunteers
- 79 people
- Sponsor
- Cellestia Biotech AG
Myeloid Leukemia, Myelodysplastic Syndrome
Treatment of Imminent Haematological Relapse in Patients With AML and MDS Following Allogeneic Stem Cell Transplantation With 5-azacitidine (Vidaza®)
Efficacy and safety of 5-Azacytidin in the treatment of the haematological relapse in patients suffering from acute myeloid leukaemia or myelodysplastic syndrome with falling CD34-chimerism after hematopoietic stem cell…
- Trial name
- NCT00422890
- Testing
- 5-Azacytidin
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Technische Universität Dresden
Haematological Malignancy
Hématologie Adulte Prevalence of Adrenal Insufficiency Post-chemotherapy Adrenocorticotropia in Adult Hematology
A recent meta-analysis involving 3753 patients treated with corticosteroids notes that the population with the highest prevalence of biological IS (68%) is onco-hematology.
- Trial name
- HemaSur (NCT03688789)
- Testing
- Hydrocortisone supplementation
- Sponsor
- Rennes University Hospital
Cytomegalovirus Infections, Haematological Malignancy
Cytomegalovirus (CMV) Reactivation in Allogeneic HSCT Recipient
This study consists of two parts: 1) Part 1, a retrospective part on 250 consecutive patients following allogeneic haematopoietic stem cell transplant (allo-HSCT) at the Royal Melbourne Hospital from 2012 to 2017, inclusive, and…
- Conditions
- Cytomegalovirus Infections, Haematological Malignancy, Organ or Tissue Transplant; Complications, Immune Suppression
- Trial name
- CReSCT (NCT03806764)
- Testing
- Blood sampling
- Where
- Australia
- Volunteers
- 370 people
- Sponsor
- Melbourne Health
Haematological Malignancy
Concordance Between 2 Means of Temperature Measure in Neutropenic Patients Hospitalized in Intensive Hematology Care Units
Connected medicine "2.0" is a major challenge that will lead in the near future to profound changes in medical practices. Our study is part of this technological transformation, which is already taking the form of multiple…
- Trial name
- TEMPET (NCT04174053)
- Testing
- Enteric capsule
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Henri Becquerel
Advanced Haematological Malignancies
AZD4573 in Novel Combinations With Anti-cancer Agents in Patients With Advanced Blood Cancer
This is a modular, multicentre, open-label, non-randomised, Phase I/II, dose-setting and expansion study including an intra-participants dose ramp up.
- Trial name
- NCT04630756
- Testing
- AZD4573, Acalabrutinib
- Where
- 17 sites in United States, Australia and 7 more
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Haematological Malignancies
Study of AZD0466 Monotherapy or in Combination in Patients With Advanced Haematological Malignancies
The purpose of the study is to the evaluate safety, tolerability, pharmacokinetics (PK), and efficacy of AZD0466 as monotherapy in partciapants with advanced haematological malignancies and also to assess drug-drug interaction…
- Trial name
- NCT04865419
- Testing
- AZD0466, Voriconazole
- Where
- 15 sites in United States, Australia and 4 more
- Volunteers
- 46 people
- Sponsor
- AstraZeneca
Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia
Hematological Disorders in EHPVO Patients
This study focuses on patients who have a condition called extrahepatic portal vein obstruction (EHPVO), where a blood clot blocks the portal vein outside the liver.
- Conditions
- Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia, Myeloproliferative Neoplasms (MPN), Antiphospholipid Syndrome (APS)
- Trial name
- EHPVO-HEM (NCT07108023)
- Testing
- No intervention (Observational Study)
- Volunteers
- 115 people
- Sponsor
- Rahab Nady
Fungal Infection
Efflux Pump Mediated Azole Resistance in Candida Albicans
Candida albicans is the major fungal pathogen causing infections in humans, ranging from superficial mucosal infection to systemic mycoses.
- Trial name
- NCT03659162
- Testing
- Azole Antifungal
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hematological Malignancies
The Use of Intensive Care in Critically Ill Cancer Haematological Patients: "TRIAL-OH"
The purpose of this study is to determine: Condition of intensive care unit (ICU) admission in patients with haematological malignancies. ICU hospital and up to one year mortality.
- Trial name
- NCT01172132
- Where
- France
- Volunteers
- 1,011 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Leukaemia, Chronic Leukaemia
Targeted Radiotherapy in HSCT for Poor Risk Haematological Malignancy
To determine whether a radiolabelled antibody that targets the bone marrow (the 'anti-CD66') can be administered safely to patients as part of the preparative treatment prior to haematopoietic stem cell transplantation ('a bone…
- Conditions
- Acute Leukaemia, Chronic Leukaemia, Myeloma, Lymphoma
- Trial name
- NCT01521611
- Testing
- Targeted radiotherapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 62 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Hematological Malignancy
Clinical Study of CAR-T Technology for the Treatment of Relapsed Refractory Malignant Haematological Tumours
The trial is designed as an early exploratory single-centre, open, single-arm clinical trial. The trial is planned to evaluate the safety and efficacy of CAR-T for the treatment of relapsed refractory malignant haematological…
- Trial name
- NCT06238336
- Testing
- CAR-T cell therapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanxi Bethune Hospital
Anemia, Iron-Deficiency, Intravenous Drug Usage
Intravenous Iron for Correction of Anaemia After Colorectal Surgery
This 4-week prospective double blind anaemia management study evaluates the effect of high-dose postoperative intravenous iron vs placebo for patients after colorectal cancer surgery.
- Conditions
- Anemia, Iron-Deficiency, Intravenous Drug Usage, Colorectal Neoplasms, Colorectal Surgery
- Trial name
- NCT02999217
- Testing
- Iron isomaltoside, Saline
- Where
- Lithuania
- Volunteers
- 100 people
- Sponsor
- Kaunas University of Medicine