Clinical trials: Head Trauma
Brain Injuries, Acute, Brain Trauma
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago).
- Conditions
- Brain Injuries, Acute, Brain Trauma, Penetrating Head Injury, Traumatic Brain Injury
- Trial name
- BRIDGE-US (NCT07636213)
- Testing
- Blood Sample Collection
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Chicago
Head Injury
The "Concussion or Brain Bleed" Trial
Researchers are trying to understand the effect of educating patients and encouraging shared decision making on rates of CT scanning in head injured patients by using an already developed app and observing the effect on the…
- Trial name
- NCT04002505
- Testing
- Concussion and Brain Bleed App (CBB)
- Where
- United States
- Volunteers
- 370 people
- Sponsor
- Mayo Clinic
Head and Neck Cancer, Head and Neck Trauma
Skin Color Matching in Head and Neck Reconstructive Surgery
This study will examine whether cutaneous reconstruction with RECELL® atop de-epithelialized tissue provides better skin color matching than standard grafting methods.
- Trial name
- RECOLOR-HN (NCT07431099)
- Testing
- RECELL® Autologous Cell Harvesting Device
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Head Injury, Traumatic Brain Injury
Selective CT for Anticoagulated Head Injured Patients
The goal is to derive and a clinical decision rule for safe exclusion of traumatic brain injury without neuroimaging in head-injured ED patients who take anticoagulant medications. The objectives are to: 1.
- Conditions
- Head Injury, Traumatic Brain Injury, Intracranial Hemorrhage, Traumatic, Blunt Head Injury
- Trial name
- Can-SCAHn (NCT05364749)
- Where
- 7 sites in Canada
- Volunteers
- 4,000 people
- Sponsor
- Dr. Kerstin de Wit
Head Trauma, Crushing Skull Injury
Detecting Traumatic Intracranial Hemorrhage With the InfraScanner 2500™ in Uganda
The goal of this study is to determine the sensitivity, specificity, and positive and negative predictive values of the portable near-infrared-based device (portable NIR-based device), the InfraScanner 2500™, to detect…
- Conditions
- Head Trauma, Crushing Skull Injury, Head Injury, Head Injuries, Multiple
- Trial name
- NCT06491173
- Testing
- InfraScanner 2500™
- Where
- 2 sites in Uganda
- Volunteers
- 180 people
- Sponsor
- Duke University
Post-Concussion Syndrome, Concussion, Brain
Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
The goal of this study is to investigate a new treatment for chronic symptoms after concussion or mild traumatic brain injury in people aged 18-65 years old.
- Conditions
- Post-Concussion Syndrome, Concussion, Brain, Mild Traumatic Brain Injury, Head Injury
- Trial name
- NCT06073886
- Testing
- Active cTBS, Imaginal exposure
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Cerebral Edema
Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional Edema
The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI patients with brain contusions and…
- Conditions
- Traumatic Brain Injury, Cerebral Edema, Head Injury Trauma
- Trial name
- DEXCON-TBI (NCT04303065)
- Testing
- Dexamethasone Oral
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Jon Pérez Bárcena
Head Injury Trauma
Treatment and Outcome of Patients With Mild Head Injury
The study aims to assess the incidence of complications, such as intracranial haemorrhages and neurological deficits, in patients with head trauma treated in the emergency departments of the Emilia-Romagna Region and to compare…
- Trial name
- BTER23 (NCT07339319)
- Where
- 4 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Head Injury Trauma, Emergencies
Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?
At the emergencies rooms, patients with head trauma meeting one of the NICE criteria, which include antiplatelet inhibitors treatment, are considered as patients with a risk of cerebral haemorrage and are taken systematically for…
- Trial name
- TCAP (NCT03687528)
- Testing
- CT-scanner
- Where
- 12 sites in France
- Volunteers
- 3,200 people
- Sponsor
- Rennes University Hospital
Brain Lesion, Head Trauma
Feasibility Study of Cortical Recording Depolarizations in Brain-injured Patients, and Their Use as Biomarkers of New Lesions.
The progression of brain lesions after severe head trauma or subarachnoid hemorrhage results from extra cranial aggression which is well controlled in intensive care and intracranial aggression which is less well known and…
- Conditions
- Brain Lesion, Head Trauma, Subarachnoid Hemorrhage
- Trial name
- SD-ICU (NCT04585503)
- Testing
- Electrode implantation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Head Trauma
Infant Minor Head Trauma Clinical Decision Rule
The purpose of this study is to validate a clinical decision rule for the management of minor head trauma in infants aged less than two years, constructed with the intention of minimizing the rate of computed tomography scans…
- Trial name
- PELICAN (NCT03050970)
- Where
- France
- Volunteers
- 8,802 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neglect, Child, Non-Accidental Trauma
Supervisory Neglect, Non-Accidental Trauma, Brief Intervention, and Treatment Referral
The Supervisory Neglect, Non-Accidental Trauma, Brief Intervention, and Treatment Referral (SunBrite) protocol is a family-empowered, risk mitigation strategy that targets families with young children who present to the ED with…
- Conditions
- Neglect, Child, Non-Accidental Trauma, Non-Accidental Injury to Child, Head Trauma
- Trial name
- SunBrite (NCT03704272)
- Testing
- SunBrite
- Sponsor
- Phoenix Children's Hospital
Head Trauma, Head Injury
Delayed IntraCranial Hemorrhage in Oral AntiCoagulant Treated Patients With Mild Traumatic Brain Injury
As a low quality, weak recommendation, it is part of the Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults, that patient with a GCS of 14-15 and anticoagulation therapy and a…
- Conditions
- Head Trauma, Head Injury, Delirium, Thrombosis
- Trial name
- dICH-OAC (NCT07195760)
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Bispebjerg Hospital
Head Trauma
Single-center Transversal Observational Study on the Evaluation of S100B Changes in Subjects Attending the Emergency Department With Head Trauma
The aim of the study is to evaluate blood levels of the calcium-binding protein S100B as a diagnostic biomarker for the management of patients with suspected traumatic brain injury.
- Trial name
- NCT07036146
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Microsurgery, Head and Neck Reconstructive Surgery
Monitoring of Bone Free Flaps With Microdialysis
Microdialysis is admitted to be reliable by numerous surgeons to monitor flaps. Nevertheless, a few authors reported follow up with microdialysis in bone flaps, and they all described the position of the catheter in the…
- Conditions
- Microsurgery, Head and Neck Reconstructive Surgery, Head and Neck Cancer, Head and/or Neck Shotgun Trauma
- Trial name
- MTM (NCT01879384)
- Testing
- CMA 70 catheter directly positioned in bone tissue
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Head Injuries
Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts
The purpose of this Phase 2, double-arm study is to identify repetitive, non-concussive head impacts that impair neurologic functioning, and to test treatments that can mitigate these effects and return functioning to normal as…
- Trial name
- MONITOR-RHI (NCT06810193)
- Testing
- Aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Traumatic Brain Injury, Mild Traumatic Brain Injury
Diagnosis of mTBI in a Community Setting
The purpose of this research study is to test whether a portable goggle system (I-PAS) is good at diagnosing mild traumatic brain injury (mTBI) in a community setting.
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Brain Injuries, Brain Injuries, Traumatic
- Trial name
- NCT03539848
- Testing
- I-PAS Goggles
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Miami
Injuries, Head, Traumatic Brain Injuries
Point of Care Testing in Emergency Departments After Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is estimated to have the highest incidence of all common neurological disorders, affecting 50 to 60 million people worldwide each year.
- Trial name
- POCkET (NCT07129577)
- Volunteers
- 400 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Head Injury, Minor, Pediatric
Hypertonic Saline for Mild TBI in Pediatric Patients
The purpose of this study is to compare two different treatments (normal saline and hypertonic saline) for concussions to see if one makes more of a difference in symptoms that can occur following concussions.
- Conditions
- Head Injury, Minor, Pediatric, Emergency Department Patient
- Trial name
- NCT07060105
- Testing
- Hypertonic Saline ( 3% Sodium Chloride Saline), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Texas at Austin
Traumatic Brain Injury, Head Injury
Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery
This study has two main goals: 1) to refine and enhance the R2R-TBI intervention; and 2) to examine the efficacy of the R2R-TBI intervention in a randomized control trial.
- Conditions
- Traumatic Brain Injury, Head Injury, Head Injuries, Closed, Brain Hemorrhage, Traumatic
- Trial name
- NCT05622461
- Testing
- Road-to-recovery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati