Clinical trials: Heart Arrest, Out-Of-Hospital
Mental Health, Stress Disorder, Post Traumatic
Psychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts
Out-of-hospital cardiac arrest is a serious emergency. In many areas, trained volunteers are alerted by a smartphone app to help before emergency services arrive.
- Trial name
- BRAVE (NCT07607808)
- Testing
- Structured Debriefing
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital, Aachen
Cardiac Arrest, Brain Injuries
A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest
Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of the extent of brain damage.
- Trial name
- COMA-PROTECT (NCT04774055)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Cardiac Arrest (CA)
Adapted Cardiopulmonary Resuscitation Study
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest.
- Trial name
- NCT07754656
- Testing
- aCPR algorithm, ERC ALS 2025
- Where
- Austria
- Volunteers
- 216 people
- Sponsor
- Johannes Kepler University of Linz
Out-Of-Hospital Cardiac Arrest
Biochemical Makers for Outcome After Pediatric out-of Hospital Cardiac Arrest
This single-center study will validate serum, imaging and clinical markers to determine outcome of pediatric patients early after Out-of-Hospital cardiac arrest (OHCA).
- Trial name
- BIMOPECA (NCT03873662)
- Testing
- Blood sample
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Cardiac Arrest
Doppler Sonography of Cerebral Blood Flow for Early Prognostication After Out-of-hospital Cardiac Arrest
Objective: To assess neurologic prognostication by early Transcranial Doppler Sonography (TCD) in comatose survivors after cardiac arrest.
- Trial name
- DOTAC (NCT03270683)
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Rennes University Hospital
Out-Of-Hospital Cardiac Arrest
Medical Dispatchers' Perception of Visual Information in Real Out-of-hospital Cardiac Arrest
Dispatcher-assisted cardiopulmonary resuscitation is a complex, nonvisual procedure that is challenging for the dispatcher. The aim was to explore the medical dispatchers' perception of bystanders' responses and dispatchers'…
- Trial name
- NCT03721666
- Testing
- CCTV footage to the medical dispatcher in OHCA
- Volunteers
- 10 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest, Pneumothorax
Post-Resuscitation Pneumothorax - Analysis of Incidence, Risk Factors and Outcome Relevance
In this retrospective study, the investigators seek to investigate the incidence of pneumothorax following possible risk factors, and elucidate its association with outcomes.
- Conditions
- Cardiac Arrest, Pneumothorax, Resuscitation
- Trial name
- NCT06182007
- Testing
- Cardiopulmonary Resuscitation
- Where
- Austria
- Volunteers
- 237 people
- Sponsor
- Auinger, Daniel MD
Cardiac Arrest
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs.
- Trial name
- OPTIVO (NCT07479836)
- Testing
- Low Volume Ventilation, High Volume Ventilation
- Where
- Canada
- Volunteers
- 1,656 people
- Sponsor
- Sunnybrook Health Sciences Centre
Out-Of-Hospital Cardiac Arrest, Pneumonia
Ceftriaxone to PRevent pneumOnia and inflammatTion aftEr Cardiac arresT (PROTECT)
Randomized-controlled trial and microbiome assessment to understand the risk-to-benefit ratio of prophylactic antibiotics (Ceftriaxone) vs placebo in patients with pneumonia and inflammation after cardiac arrest outside the…
- Trial name
- PROTECT (NCT04999592)
- Testing
- Standard of care without prophylaxis, Antibiotic prophylaxis
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- David J. Gagnon
Sudden Cardiac Death, Acute Myocardial Infarction
Thrombus and Inflammation Study in Sudden Cardiac DEath
Sudden death is a natural death occurring within one hour after the onset of symptoms. It remains a major public health problem and accounts for 5 to 10 % of the annual total mortality ie about 300.000 in the United States.
- Trial name
- TIDE (NCT00748111)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-of-hospital Cardiac Arrest (OHCA), Agonal Breathing
CPR and Agonal Breathing Recognition Training for Police Officers
This study will evaluate an educational training program for police officers in New Taipei City, Taiwan. Police officers may arrive at out-of-hospital cardiac arrest events before emergency medical services and may be able to…
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Agonal Breathing, Cardiopulmonary Resuscitation Training
- Trial name
- CPR-AB Police (NCT07695766)
- Testing
- CPR Refresher and Agonal Breathing Recognition Training
- Where
- Taiwan
- Volunteers
- 3,439 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA)
Abdominal Aortic Tourniquet Application for Non-Traumatic Out-of-Hospital Cardiac Arrest
The aim of the study is to investigate whether occluding the abdominal aorta with an external device could be a potential therapeutic option in cases of non-traumatic cardiac arrest occurring outside of a hospital.
- Conditions
- Cardiac Arrest (CA), Out-of-hospital Cardiac Arrest (OHCA), Asystole, Pulseless Electrical Activity
- Trial name
- ATTICA (NCT07573566)
- Testing
- Abdominal Aortic Junction Tourniquet in non-traumatic out-of-hospital cardiac arrest
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Klinikum Klagenfurt am Wörthersee
Health-Related Quality-of-Life, Satisfaction With Care
V-CARE (Virtual Care After REsuscitation)
Out-of-hospital cardiac arrest (OHCA) survivors and their relatives may face challenges following hospital discharge, relating to mood, cognition, and returning to normal day-to-day activities.
- Conditions
- Health-Related Quality-of-Life, Satisfaction With Care, Self-management Behaviors
- Trial name
- V-CARE (NCT07498764)
- Testing
- Virtual Care After REsuscitation, Digital Information Leaflet
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Out-Of-Hospital Cardiac Arrest
The Systematic Approach for Identification of Cause Among Out-of-hospital Cardiac Arrest Survivors
The cause of cardiac arrest mostly determines outcomes of cardiac arrest survivors. Identifying and treating the cause of cardiac arrest constitute a critical part in post-arrest care.
- Trial name
- NCT06012838
- Testing
- Cause classification of OHCA protocol
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Cardiac Arrest, Cardiopulmonary Resuscitation
Comparison of Manual Cardiopulmonary Resuscitation (CPR) Versus Automatic CPR Machine During Ambulance Transport.
This is a randomized controlled prospective study which assigned patient to receive manual CPR or automatic CPR machine use. The quality and efficacy between manual CPR and machine CPR will be evaluated.
- Trial name
- NCT00308815
- Testing
- Automatic CPR machine
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Out-Of-Hospital Cardiac Arrest
The Development of the Simulation Curriculum and AI-incorporated Assessment Tool for Transesophageal Echocardiography
This study aims to establish a novel transesophageal echocardiography (TEE) simulation curriculum based on previous research results and suggestions from the American College of Emergency Physicians.
- Trial name
- NCT06567912
- Testing
- TEE simulation curriculum
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction
Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
This study evaluate the association of some in-ICU factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Coma, Outcome, Fatal
- Trial name
- ACR-MI (NCT04584463)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Out-of-hospital Cardiac Arrest (OHCA)
Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome
This study will test whether a lower dose of epinephrine (0.5 mg) given during emergency treatment for out-of-hospital cardiac arrest helps more patients survive with good brain function, compared to the standard dose (1 mg).
- Trial name
- Low-EPI (NCT07442071)
- Testing
- Epinephrine 0.5 mg intravenous bolus, Epinephrine 1 mg intravenous bolus
- Where
- 26 sites in France
- Volunteers
- 4,336 people
- Sponsor
- Central Hospital, Nancy, France
Cardiopulmonary Arrest
Effect of ETI Performance on CPR Outcomes
This is a clinical observation study based on analysis of video-clip data of cardiopulmonary resuscitation (CPR) for out-of hospital cardiac arrest (OHCA) in emergency department.
- Trial name
- NCT04451733
- Testing
- Endotracheal intubation
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Konkuk University Medical Center
Out of Hospital Cardiac Arrest
Developing a Digital Handover Application for Paramedics to Provide a Personalized Approach to Pre-hospital Stratification for Out of Hospital Cardiac Arrest
A prospective study validating the role of the MIRACLE2 score in patients with resuscitated out of hospital cardiac arrest in a pre-hospital setting.
- Trial name
- RAPID-MIRACLE (NCT05185063)
- Testing
- Point of Care blood test
- Volunteers
- 500 people
- Sponsor
- King's College London