Clinical trials: Heart Infarction
Myocardial Infarction, Myocardial Ischemia
A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy Volunteers
The purpose of this study is to determine whether the intravenous administration of single- and multiple-ascending doses of Thymosin Beta 4 is safe and tolerable in healthy volunteers.
- Trial name
- NCT00743769
- Testing
- thymosin beta 4
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- RegeneRx Biopharmaceuticals, Inc.
Acute Myocardial Infarction (AMI)
Counterpulsation Reduces Infarct Size Pre-PCI for AMI
Subjects with anterior acute STEMI who receive an IABC before primary PCI will have decreased MI size.
- Trial name
- CRISP-AMI (NCT00833612)
- Testing
- Counterpulsation with IAB
- Where
- 40 sites in United States, Australia and 8 more
- Volunteers
- 339 people
- Sponsor
- Datascope Corp.
Myocardial Infarction
Abbott i-STAT High Sensitivity Troponin I Study
The goal of this observational multi-center study is to evaluate the clinical performance of the i-STAT hs-TnI test (i-STAT High Sensitivity Troponin I) using the investigational i-STAT hs-TnI cartridge for the proposed intended…
- Trial name
- i-STAT hs-TnI (NCT05629572)
- Testing
- i-STAT hs-TnI Cartridge Testing on i-STAT 1 and i-STAT Alinity
- Where
- 28 sites in United States
- Volunteers
- 3,697 people
- Sponsor
- Abbott Point of Care
PreDiabetes, Myocardial Infarction
Effect of Dapagliflozin on the Progression From Prediabetes to T2DM in Subjects With Myocardial Infarction
It is hypothesize that, because dapagliflozin will reverse the metabolic defects responsible for the development of prediabetes (i.e.
- Conditions
- PreDiabetes, Myocardial Infarction, T2DM (Type 2 Diabetes Mellitus), CVD
- Trial name
- NCT03658031
- Testing
- Dapagliflozin 10mg
- Where
- Qatar
- Volunteers
- 576 people
- Sponsor
- Hamad Medical Corporation
Heart Attack and Stroke
Emergency Call for Heart Attack and Stroke (ECHAS) - ECHAS One Study
ECHAS One will test the use of a smartphone app to assist patients to decide if it is necessary to call for emergency care with symptoms that could represent a heart attack or stroke.
- Trial name
- ECHAS (NCT05230069)
- Testing
- Interview
- Volunteers
- 200 people
- Sponsor
- Emergency Call for Heart Attack and Stroke (ECHAS)
Acute Myocardial Infarction
Long-term Follow-up Study Following the Approval of Hearticellgram-AMI Administration
This Long-term follow-up is designed to evaluate the safety of patient with Acute Myocardial Infarction who had administered Hearticellgram-AMI.
- Trial name
- NCT07400458
- Testing
- Hearticellgram-AMI
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Pharmicell Co., Ltd.
Cardiovascular Risk Factor, Cardiovascular Diseases
Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Further LDL-C Reduction
This study is to assess LDL-C reductions at Week 52 with monthly (Q4W [≤31 days]) dosing of LIB003 (lerodalcibep) 300 mg administered subcutaneously (SC) compared to placebo in patients with CVD, or at high risk for CVD, on a…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Stroke, Hypercholesterolemia
- Trial name
- LIBerate-HR (NCT04806893)
- Testing
- lerodalcibep
- Where
- 6 sites in United States, India and 1 more
- Volunteers
- 900 people
- Sponsor
- LIB Therapeutics LLC
STEMI - ST Elevation Myocardial Infarction, CAD
CorPath GRX STEMI Study
This study will evaluate the performance of the CorPath GRX System in Robotic Primary PCI (RPPCI) in the treatment of ST-elevated myocardial infarction (STEMI).
- Trial name
- TREAT GRX (NCT04459299)
- Testing
- Robotic-PCI (CorPath GRX System)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Siemens Healthineers Endovascular Robotics, Inc.
Coronary Artery Disease
An Evaluation of the Commercially Available Medtronic Resolute Integrity Zotarolimus-Eluting Coronary Stent System
The purpose of this post approval study is to conduct a prospective, multicenter evaluation of the procedural and clinical outcomes of subjects that are treated with the commercially available Medtronic Resolute Integrity…
- Trial name
- RI-US (NCT01638507)
- Testing
- Resolute Integrity Stent
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Medtronic Vascular
Cardiovascular Disease and Lipoprotein(a)
Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
- Trial name
- Lp(a)HORIZON (NCT04023552)
- Testing
- TQJ230
- Where
- 902 sites in United States, Argentina and 41 more
- Volunteers
- 8,323 people
- Sponsor
- Novartis Pharmaceuticals
Myocardial Infarction, Arrhythmia, Ventricular
MASTER II - Microvolt T Wave Alternans Testing for Risk Stratification of Post MI Patients
The purpose of the study is to determine the usefulness of Microvolt T Wave Alternans (MTWA) testing of patients that have had a heart attack and have decreased pumping ability of the lower chamber of their heart.
- Conditions
- Myocardial Infarction, Arrhythmia, Ventricular, Ischemic Cardiomyopathy
- Trial name
- NCT00305214
- Testing
- T Wave Alternans Test
- Where
- 47 sites in United States
- Volunteers
- 405 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
PCI Patients, de Novo Coronary Lesions
iLITE, Clinical Performance of the Angiolite™ Drug-Eluting Stent
Prospective, multi-center, all comers, post market clinical follow-up (PMCF) registry.
- Conditions
- PCI Patients, de Novo Coronary Lesions, Restenotic Coronary Lesions, Acute Myocardial Infarction (AMI)
- Trial name
- iLITE (NCT07887230)
- Testing
- Percutaneous Coronary Intervention
- Volunteers
- 5,000 people
- Sponsor
- iVascular S.L.U.
STEMI
The First-In-Man Use of Coronary Sinus Balloon Pump in STEMI Patients Treated by Primary PCI
This is a prospective, multicenter clinical investigation aiming to evaluate the safety and efficacy of the coronary sinus balloon pump in its first application in patients with acute ST-segment elevation myocardial infarction…
- Trial name
- REVIVE-FIM (NCT07082153)
- Testing
- the coronary sinus balloon pump
- Volunteers
- 10 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Cardiovascular Disease
The Evaluation of Bococizumab (PF-04950615;RN316) in Reducing the Occurrence of Major Cardiovascular Events in High Risk Subjects
This study evaluates the PCSK9 inhibitor, Bococizumab (PF-04950615;RN316), compared to placebo, in reducing the occurrence of major cardiovascular events, including cardiovascular death, myocardial infarction, stroke, and…
- Trial name
- SPIRE-1 (NCT01975376)
- Testing
- bococizumab (PF-04950615)
- Where
- 1,745 sites in United States, Argentina and 34 more
- Volunteers
- 16,784 people
- Sponsor
- Pfizer
STEMI - ST Elevation Myocardial Infarction
Effects of Salvianolate Injection on Myocardial Microcirculation in Patients With Acute STEMI After Primary PCI
To evaluate the influence of Salvianolate injection on myocardial microcirculation perfusion in subjects with STEMI who underwent primary PCI
- Trial name
- SISTEMI (NCT03045562)
- Testing
- Normal saline, Salvianolate injection
- Where
- China
- Volunteers
- 536 people
- Sponsor
- Green Valley Group of China
Acute Myocardial Infarction
Safety Study of Clinical Cell Transplant Therapy Using Hearticellgram-AMI for Patients With Acute Myocardial Infarction
The purpose of this study is to evaluate the safety of the previously conducted clinical trial cell transplant therapy using Hearticellgram-AMI for patients with acute myocardial infarction.
- Trial name
- NCT01595113
- Volunteers
- 41 people
- Sponsor
- Pharmicell Co., Ltd.
Stent Thrombosis, Ischemic Stroke
Association Between Genetic Variant Scores and P2Y12 Inhibitor Effects
The goal of this study is to predict and prevent adverse drug events by investigating the impact of genetic variants, demographics, and environmental factors in subjects status post myocardial infarction and percutaneous coronary…
- Conditions
- Stent Thrombosis, Ischemic Stroke, Myocardial Infarction, Acute Coronary Syndrome
- Trial name
- CARES1 (NCT04580602)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Cipherome, Inc.
AMI Cardiogenic Shock
Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
The observational study titled "Observational Assessment of Support with Impella Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock (OASIS-AMICS)" aims to evaluate the safety outcomes of patients with…
- Trial name
- OASIS-AMICS (NCT06964685)
- Testing
- Impella
- Where
- 21 sites in United States
- Volunteers
- 350 people
- Sponsor
- Abiomed Inc.
Myocardial Infarction, Acute, Myocardial Infarction
A Behavioral Economics-Based Telehealth Intervention to Improve Post-MI Medication Adherence
The proposed study is a pilot randomized clinical trial (RCT). Participants in the intervention arm will participate in a 90-day adherence promotion program based on the theory of behavioral economics and administered through the…
- Trial name
- NCT03022266
- Testing
- Financial Incentive and Mobile Phone App
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Wellth Inc.
Coronary Artery Disease
The Study to Assess AMI Treated With Balloon Angioplasty.
The main objective of this study is to assess the effectiveness and safety of the CYPHER™ (CYPHER SELECT™) (Sirolimus-eluting) stent in reducing the occurrence of a composite endpoint of target vessel failure (TVF) in subjects…
- Trial name
- TYPHOON (NCT00232830)
- Testing
- drug-eluting stent, bare-metal stent
- Where
- 2 sites in France, Germany
- Volunteers
- 715 people
- Sponsor
- Cordis US Corp.