Clinical trials: Heavy Smokers
Cigarette Smoking, Alcohol Consumption
Effects of Varenicline in Heavy Drinking Smokers
This laboratory study will examine if varenicline can reduce alcohol-induced smoking lapse in heavy drinking smokers.
- Trial name
- VAR (NCT02488889)
- Testing
- Varenicline, Alcohol
- Where
- United States
- Sponsor
- University of California, Los Angeles
Lung Cancer (Diagnosis), Smoking Cessation
Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers
Lung cancer is common and serious, but when detected early, the chances of recovery are significantly better. Tobacco use is the leading cause.
- Conditions
- Lung Cancer (Diagnosis), Smoking Cessation, Lung Neoplasm
- Trial name
- NCT07860359
- Testing
- Image-Based Counseling, Smoking Cessation Coaching, Low-Dose Chest Computed Tomography (LDCT)
- Where
- Switzerland
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Hôpital Fribourgeois
Cigarette Smoking, Smoking Cessation
Benefits of Tobacco Free Cigarette
Background. Smoking is considered a global public health problem. For this reason, the smoking dependence was called by experts as a global epidemic.
- Trial name
- BETOFREE (NCT02422914)
- Testing
- Smoking cessation program TFC and activity tracker, Smoking cessation program TFC-free and activity tracker, Smoking cessation program and activity tracker
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Milan
Smoking Dependence, Smoking Among Youth
Efficacy of Diaphragmatic Proprioceptive Neuromuscular Facilitation on Functional Capacity and Pulmonary Function in Heavy Twenties Smokers
Although research on the health risks of e-cigarettes is still limited, there is increasing evidence of debilitating lung disease and general immune dysfunction from e-cigarettes, leading to various infections.
- Trial name
- NCT07003893
- Testing
- Diaphragmatic Proprioceptive Neuromuscular Facilitation + Aerobic exercises
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Lung Cancers
Identification and Validation of Blood-Based Biomarkers for Early Detection of Asymptomatic Lung Cancer in High-Risk Heavy Smokers
The goal of this observational study is to develop and evaluate a blood test for asymptomatic heavy smokers to screen for those at highest risk of developing lung cancer.
- Trial name
- NCT06816121
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Everest Detection, Inc.
Lung Cancer
Sputum Cytology in Screening Heavy Smokers For Lung Cancer
RATIONALE: Screening tests, such as sputum cytology, may help doctors find tumor cells early and plan better treatment for lung cancer.
- Trial name
- NCT00103363
- Testing
- cytology specimen collection procedure, physiologic testing, annual screening
- Where
- United States
- Volunteers
- 3,270 people
- Sponsor
- University of Colorado, Denver
Nicotine Addiction
Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers
Background: Central nicotinic acetylcholine receptors (nAChRs) are primary targets for the action of nicotine. In addition to being involved in tobacco dependence, they are also involved in a variety of brain disorders, including…
- Trial name
- NCT01038245
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cigarette Smoking-Related Carcinoma
Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers
This phase II trial tests whether broccoli seed and sprout extract works to break down cancer causing substances of tobacco in heavy smokers. Smokers are at increased risk for developing lung, head and neck, and other cancers.
- Trial name
- NCT05121051
- Testing
- Biospecimen Collection, Broccoli Sprout/Broccoli Seed Extract Supplement, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Non Small Cell Lung Cancer
Study of Blood, Tumor and Adjacent Normal Tissue Samples From Chinese Smoking Induced Lung Cancer Patients
This is an epidemiological,multicenter study of genomic and expression profiles of patients with newly diagnosed NSCLC.Two hundred and fifty NSCLC patients who fulfill the criteria are to be recruited by investigational…
- Trial name
- CHOICE (NCT02113852)
- Volunteers
- 250 people
- Sponsor
- Guangdong Association of Clinical Trials
Peri-Implantitis, Type 2 Diabetes Mellitus
Surgical Treatment of Periimplantitis in Patients With Risk Factors
This study evaluates clinical and radiographic parameters among riks factor groups in patients with periimplantitis. This study will also treat and evaluate the patients response before and after surgical treatment.
- Conditions
- Peri-Implantitis, Type 2 Diabetes Mellitus, Smoking, Cigarette, Periodontal Diseases
- Trial name
- NCT03814434
- Testing
- Non-Surgical treatment, Surgical Treatment
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Luiz Antonio Pugliesi Alves de Lima
Smoking Cessation
Nicotine Substitute Prescribed at Hourly Intake or ad Libitum for Heavy Smokers Willing to Quit
Objective: To assess the impact of instructional guidance in the regular use of use nicotine nasal spray (NNS) on the true use of NNS during the first three weeks of smoking cessation for heavy smokers who are willing to quit.
- Trial name
- SUNIC (NCT00861276)
- Testing
- Nasal Spray Nicotine Substitute (Experimental), Nasal Spray Nicotine Substitute (ad libitum)
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Heavy Smoker or Non-smoker
Antioxidant Effect of Aged Garlic Extract
This is a randomized, double-blind, placebo controlled, crossover study to determine the antioxidant effect of aged garlic extract. This study will also compare the oxidative status in heavy smokers with that in non-smokers.
- Trial name
- NCT02019368
- Testing
- Aged garlic extract
- Where
- Japan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Lung Cancer, Tobacco Use Disorder
Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. Green tea extract may keep cancer from forming.
- Trial name
- NCT00573885
- Testing
- defined green tea catechin extract
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- British Columbia Cancer Agency
Atherosclerosis, Smoking
Vascular Endothelial Protection Effects of Dextromethorphan
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular protection effect on heavy smokers.
- Conditions
- Atherosclerosis, Smoking, Inflammation
- Trial name
- NCT00605605
- Testing
- Dextromethorphan
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Cancer
Green Tea Anticancer Mechanisms in Smokers
The purpose of this study is to determine whether green tea may lower the risk of certain cancers.
- Trial name
- NCT01162642
- Testing
- Green Tea
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Philip Diaz
Cigarette Smoking, Alcohol Use Disorders
Varenicline + Prazosin for Heavy Drinking Smokers
The purpose of this study is to examine the effect of varenicline and prazosin on smoking, drinking, and sleep among cigarette smokers who report heavy alcohol use. Varenicline is an FDA approved smoking cessation medication.
- Trial name
- NCT02193256
- Testing
- Varenicline, Prazosin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Smokers
Isometric Versus Isotonic Trunk Muscle Strength Training on Lung Function in Heavy Smokers
Smoking is a major public health concern, significantly affecting lung function and overall respiratory health. Heavy smoking leads to chronic obstructive pulmonary disease (COPD), emphysema, and a decline in lung capacity.
- Trial name
- NCT07241624
- Testing
- Isometric trunk exercises, Isotonic trunk exercises
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- MTI University
Lung Cancer
Celecoxib in Preventing Lung Cancer in Former Heavy Smokers
RATIONALE: Chemoprevention therapy uses certain drugs to try to prevent the development or recurrence of cancer. Celecoxib may be effective in preventing the development or recurrence of lung cancer in former heavy smokers.
- Trial name
- NCT00055978
- Testing
- celecoxib
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of California, Los Angeles
Smoking Cessation
The Effectiveness of Using E-Cigarettes for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers
The goal of this clinical trial is to evaluate effectiveness of using e-cigarettes as harm reduction strategy for smoking cessation and decreasing risk of diseases in heavy smokers.
- Trial name
- NCT05639790
- Testing
- Electronic cigarettes + Health Counselling, Health Counselling
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shenzhen Smoore Technology Limited
HEAVY TOBACCO SMOKERS
Docosahexaenoic Acid (DHA) Effects on Cognitive Function, Craving and Psychosocial Factors in Heavy Cigarette Smokers
The purpose of this study is to assess effects of Docosahexaenoic Acid (DHA) as an add-on novel supplement on quality of life, cognitive function, craving and psychosocial factors in heavy cigarette smokers.
- Trial name
- NCT01284660
- Testing
- DHA
- Where
- Israel
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center