Clinical trials: Hemodiafiltration
End-Stage Kidney Disease, Hemodiafiltration
Comparison of Citrate and Heparin Anticoagulation During Postdilution Hemodiafiltration
This randomized crossover clinical trial will compare regional citrate anticoagulation (RCA) and standard heparin anticoagulation (HA) during postdilution hemodiafiltration (HDF) in chronic dialysis patients with end-stage kidney…
- Conditions
- End-Stage Kidney Disease, Hemodiafiltration, Chronic Hemodialysis, Renal Failure
- Trial name
- CITRA-HDF (NCT07618858)
- Testing
- Regional citrate anticoagulation, Unfractionated heparin
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Renal Dialysis, Hemodiafiltration
Effect of Intradialytic Exercise on Left Ventricular Diastolic Function in Hemodialysis Patients
Introduction: Cardiovascular disease is the leading cause of morbidity and mortality in patients undergoing hemodialysis, largely due to structural cardiac changes associated with left ventricular diastolic dysfunction.
- Conditions
- Renal Dialysis, Hemodiafiltration, Diastolic Dysfunction, Kidney Failure
- Trial name
- EXE-HDF (NCT06584734)
- Testing
- Not exercise, Exercise during hemodiafiltration session
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis
Expanded Hemodialysis Versus High-Volume Online Hemodiafiltration for Uremic Toxin Removal
People with advanced kidney disease need dialysis to remove waste products from the blood. Some of these waste products, called uremic toxins, are small, while others are medium-sized and more difficult to remove.
- Conditions
- End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis, Renal Dialysis, Uremia; Chronic
- Trial name
- REMOV-HDx (NCT07348536)
- Testing
- Expanded Hemodialysis With Medium Cut-Off Membrane, High-Volume Online Hemodiafiltration
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hemodialysis, Hemodiafiltration
Hemodiafiltration Versus Hemodialysis in Older People
This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF).
- Conditions
- Hemodialysis, Hemodiafiltration, Fatigue Symptom, Quality of Life of Patients
- Trial name
- HD-OLDER (NCT07278973)
- Testing
- High-flux hemodialysis, Hemodiafiltration
- Where
- 4 sites in France
- Volunteers
- 62 people
- Sponsor
- AUB Santé
Hemodialysis, Hemodiafiltration
Comparing Hemodiafiltration with and Without Hemoadsorption
Goals: The aim of the study is to assess the efficacy and safety of the combination of HDF + HA compared to HDF. To do this, we will evaluate the elimination of a wide range of molecular weight molecules, including small…
- Conditions
- Hemodialysis, Hemodiafiltration, Hemoadsorption
- Trial name
- NCT06710834
- Testing
- Hemoadsorption cartridge, Hemodiafiltration
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
End Stage Renal Disease on Dialysis, Biocompatibility
Efficiency and Biocompatibility in Hemodiafiltration Procedure
Hemodiafiltration is a modern, increasingly used special hemodialysis method. Compared to hemodialysis, it allows greater clearance of medium- and high-molecular-weight molecules.
- Conditions
- End Stage Renal Disease on Dialysis, Biocompatibility, Anticoagulation, Hemodiafiltration
- Trial name
- NCT06807905
- Testing
- Heparin anticoagulation, Citrate anticoagulation
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration
Comparative Effectiveness of Oxiris Hemofilters Versus Conventional Hemofilters in Septic Patients
We divided patients in 2 groups. First group was the patients who received Oxiris filters during CRRT. Second group was the patiens who have received CRRT filters other than Oxiris.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Hemodiafiltration, Cytokine
- Trial name
- NCT06735365
- Testing
- CRRT
- Where
- Turkey (Türkiye)
- Volunteers
- 426 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Hemodiafiltration, Sepsis
Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)
Study: Open label, non-randomized, observational, descriptive and prospective pharmacokinetic. Patients: sepsis patients undergoing continuous renal replacement therapy (CRRT) and admitted at the Intensive care unit of Bellvitge…
- Conditions
- Hemodiafiltration, Sepsis, Acute Kidney Injury
- Trial name
- NCT04033029
- Testing
- Continuous venovenous hemodiafiltration with high adsorption membrane (oXiris®), Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
End-stage Renal Disease, Prevention of Thromboembolic Events
Study to Investigate the Safety of a Drug Called Osocimab at Low and High Doses in Adult Patients With Kidney Failure Requiring Regular Hemodialysis
In this study researchers want to learn about the safety of drug Osocimab at lower-dose and higher-doses in adult participants with kidney disease undergoing regular dialysis (a procedure that uses a machine to get rid of toxins…
- Conditions
- End-stage Renal Disease, Prevention of Thromboembolic Events, Hemodialysis, Hemodiafiltration
- Trial name
- CONVERT (NCT04523220)
- Testing
- BAY1213790 (Osocimab)
- Where
- 151 sites in United States, Australia and 17 more
- Volunteers
- 704 people
- Sponsor
- Bayer
Hemodiafiltration, Heparin
Citrate Dialysate in Online Hemodialfiltration
Online hemodiafiltration (Ol-HDF) is increasingly being used for patients on chronic dialysis due to in its superiority compared with standard hemodialysis HDF.
- Conditions
- Hemodiafiltration, Heparin, Haemodialysis, Citrate Reaction
- Trial name
- NCT05280106
- Testing
- Pre-dilution online hemodiafiltration with citrate dialysate, Post-dilution hemodiafiltration with citrate dialysate
- Where
- 2 sites in Thailand
- Volunteers
- 9 people
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Multiple Myeloma, Acute Kidney Injury
Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury
In patients with multiple myeloma-related acute kidney injury, compare the renal outcome of chemotherapy combined with HFR-SUPRA to chemotherapy combined with hemodialysis.
- Conditions
- Multiple Myeloma, Acute Kidney Injury, Hemodiafiltration With Ultrafiltrate Regeneration (HFR)
- Trial name
- NCT05429515
- Testing
- HFR-SUPRA, hemodialysis, Chemotherapy
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
COVID-19, Hemodiafiltration
Immune Function in Elderly Patients With Mild to Moderate COVID-19 on Hemodialysis
This randomized controlled trial will focus on the effects of early oral nutritional supplementation on immune function in elderly patients with mild to moderate COVID-19 on maintenance hemodialysis.
- Trial name
- NCT05366205
- Testing
- Oral nutritional supplement, Nutrition consultation
- Volunteers
- 112 people
- Sponsor
- Ruijin Hospital
End Stage Renal Disease, Hemodiafiltration
To Assess the Effect of HDF Versus High Flux Dialysis on Free Light Chains and Cumulative Albumin Loss, in End Stage Renal Disease Patients.
Removal of uremic toxins is the main goal of HD, It was improved by using high volume convective technique with high flux (HF) dialyzer.
- Conditions
- End Stage Renal Disease, Hemodiafiltration, Hemodialysis
- Trial name
- NCT04747067
- Testing
- BIOPURE 260HF dialyzer
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Assessment of Activity of Anti-Xa Factor in Patients Treated With Continuous Veno-venous Hemodiafiltration Receiving Anticoagulant Prophylaxis
Impact of Continuous Veno-venous Hemodiafiltration on Efficacy of Administration of Prophylactic Doses of Enoxaparin or Fondaparinux in Critically Ill Patients.
Dose of anticoagulant prophylaxis in patients with continuous veno-venous hemodiafiltration may be insufficient to keep anti-Xa factor activity in prophylactic range.
- Trial name
- NCT04671160
- Testing
- Assessment the activity of anti-Xa factor.
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Hemodiafiltration, Chronic Kidney Disease Requiring Chronic Dialysis
Effect of Hemodiafiltration Plus MCOs on Uremic Toxins Removal
Conventional hemodialysis is essential for the treatment of ESRD patients by reducing serum concentration of uremic toxins and correcting fluid overload. Nevertheless, HD removes almost exclusively low-range uremic toxins.
- Trial name
- NCT03938285
- Testing
- Theranova 400 membrane, FxCordiax 120 membrane
- Where
- 2 sites in Mexico
- Volunteers
- 12 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Hemodiafiltration
Comparison of Post- and Pre-dilutional Hemodiafiltration in Hemodialysis Patients
Hemodiafiltration (HDF) is a choice of treatment modalities for patients with end-stage renal disease. Hemodiafiltration, combining diffusion and convection, may increase removal of large and middle molecule uremic toxins…
- Trial name
- NCT03288285
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
End-stage Renal Disease, Renal Replacement Therapy
Can High Convection Volumes be Achieved in Each Patient During Online Post-dilution Hemodiafiltration?
Two recent randomized controlled trials (RCT) on online hemodiafiltration (HDF) did not show a treatment effect on patient survival when compared with low- or high-flux hemodialysis.
- Conditions
- End-stage Renal Disease, Renal Replacement Therapy, Hemodiafiltration, Convection Volume
- Trial name
- NCT01877499
- Testing
- Optimization of HDF key parameters
- Where
- 7 sites in Netherlands
- Volunteers
- 86 people
- Sponsor
- Amsterdam UMC, location VUmc