Clinical trials: Hemorrhagic Shock
Hemorrhage, Trauma
Evaluation of Transthoracic Echocardiography Parameters and Their Changes in Blood Donor Volunteers
This study investigates the impact of blood donation on transthoracic echocardiography (TTE) parameters in healthy volunteers, aiming to enhance the understanding of hemodynamic changes associated with mild blood loss and assess…
- Conditions
- Hemorrhage, Trauma, Shock Hypovolemic
- Trial name
- EDoS (NCT07207629)
- Testing
- Transthoracic Echocardiography measurements
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Hypofibrinogenemia, Hemorrhage
Cryo-FIRST: Effectiveness of INTERCEPT Fibrinogen Complex (IFC) for Trauma-Associated Hemorrhage
The objective of this multicenter, single-arm, observational study is to determine the feasibility and effectiveness of early administration of FDA-approved, pre-thawed Pathogen Reduced Cryoprecipitated Fibrinogen Complex…
- Conditions
- Hypofibrinogenemia, Hemorrhage, Trauma Associated Hemorrhage, Hemorrhagic Shock
- Trial name
- CRYO-FIRST (NCT07218185)
- Testing
- Pathogen Reduced Cryoprecipitated Fibrinogen Complex
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Cerus Corporation
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Trauma, Hemorrhage
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and…
- Trial name
- CAVALIER (NCT05958342)
- Testing
- Calcium Gluconate, Vasopressin
- Where
- 18 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- Jason Sperry
Wounds and Injuries, Shock, Hemorrhagic
Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and…
- Trial name
- TROOP (NCT05638581)
- Testing
- LTOWB, Components
- Where
- 13 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- University of Alabama at Birmingham
Hemorrhagic Shock, Trauma Injury
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion.
- Trial name
- MATIC-2 (NCT06070350)
- Testing
- Low Titer Group O Whole Blood (LTOWB), Tranexamic Acid (TXA), Component Therapy (CT)
- Where
- 23 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Philip Spinella
Hemorrhagic Shock, Trauma
Inferior Vena Cava Versus Subclavian Vein Collapsibility for Predicting Fluid Responsiveness in Trauma Hemorrhagic Shock
Hemorrhagic shock from severe bleeding is a leading cause of preventable death in trauma patients. Intravenous (IV) fluid resuscitation is essential for stabilizing blood pressure and organ perfusion, but administering too much…
- Conditions
- Hemorrhagic Shock, Trauma, Hypovolemia, Fluid Responsiveness
- Trial name
- NCT07817966
- Volunteers
- 120 people
- Sponsor
- Assiut University
Trauma, Haemorrhagic Shock
Fibrinogen Early In Severe Trauma StudY II
Annually over 7000 Australians are treated for severe trauma. Haemorrhage secondary to severe trauma is a major cause of potentially preventable death and poor outcomes in Australian adults.
- Conditions
- Trauma, Haemorrhagic Shock, Coagulopathy
- Trial name
- FEISTY II (NCT05449834)
- Testing
- Fibrinogen Concentrate, Cryoprecipitate
- Where
- 24 sites in Australia, New Zealand
- Volunteers
- 900 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Hemorrhagic Shock, Pediatric Trauma
Effect of Resuscitation on Gastric Emptying Using POCUS in Pediatric Trauma Patients
Pediatric trauma often leads to hemorrhagic shock, which reduces blood flow to the digestive tract and delays gastric emptying. This delay can cause fluid and food to remain in the stomach, increasing the risk of pulmonary…
- Conditions
- Hemorrhagic Shock, Pediatric Trauma, Delayed Gastric Emptying, Gastric Dysmotility
- Trial name
- NCT07810907
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hemorrhagic Shock, Pelvic Fractures
Hemorrhagic Shock in Orthopedic Fractures
The goal of this observational study is to learn about the incidence and predators of hemorrhagic shock in patients with Long bone and pelvic fractures .The main question it aims to answer is: In which bone fracture the…
- Conditions
- Hemorrhagic Shock, Pelvic Fractures, Long Bone Fractures
- Trial name
- NCT07695129
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Sohag University
Cardiac Arrest From Trauma
Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma
The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed…
- Trial name
- EPR-CAT (NCT01042015)
- Testing
- Emergency preservation and resuscitation, Standard resuscitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland, Baltimore
Trauma and Emergency Care, Shock,Hemorrhagic
Delayed Fluids in Hemorrhagic Shock Due to Severe Injuries.
This study will provide information on the quality of care in hemorrhagic shock of severe injuries in a limited resource facility of Latin America, the strategies of fluid resuscitation, and outcomes.
- Conditions
- Trauma and Emergency Care, Shock,Hemorrhagic, Intravenous Fluid Therapy
- Trial name
- PERMIT-LATAM (NCT07530653)
- Testing
- Crystalloid below 1000 mL., IV fluids more than 1,000 mL
- Where
- Colombia
- Volunteers
- 716 people
- Sponsor
- Hospital Departamental de Villavicencio
Severe Trauma, Traumatic Shock
Efficacy and Safety of Early Use PCC in Severe Trauma
Uncontrolled hemorrhage within 24 hours after severe trauma is the main cause of death in trauma patients. Hemorrhagic shock may be accompanied by traumatic coagulopathy in the early stages of severe trauma.
- Trial name
- eFAST (NCT05738642)
- Testing
- 4 factor Prothrombin Complex Concentrates
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hemorrhage, Cardiac Surgery
Biological and Clinical Relevance of Quantra Viscoelastic Hemostatic Assay in Hemorrhagic Cardiac Surgery
The goal of this observational study is to assess the correlation between Quantra viscoelastometric assay and laboratory hemostasis biology in a cardiac surgery cohort presenting with acute hemorrhage in the operating room.
- Conditions
- Hemorrhage, Cardiac Surgery, Hemorrhagic Shock
- Trial name
- QASH (NCT07105904)
- Testing
- Viscoelastometric hemostatic assay
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Pitié-Salpêtrière Hospital
Hemorrhage, Trauma
Empiric Calcium in Massive Transfusion
Calcium helps blood to clot and thereby stop bleeding. Trauma patients who experience large volume blood loss often require blood transfusions and bleeding is the most common cause of death.
- Conditions
- Hemorrhage, Trauma, Hypocalcemia, Shock, Hemorrhagic
- Trial name
- NCT05953376
- Testing
- Calcium Gluconate
- Sponsor
- University of California, Irvine
Acute Kidney Injury
Comparison of Early Proton Pump Inhibitor Initiation Versus Usual Care on Acute Kidney Injury in Hemorrhagic Shock Patients
The investigators propose a single-center, randomized, controlled trial to determine whether early initiation of proton pump inhibitor (PPI), pantoprazole, will decrease acute kidney injury (AKI) for trauma patients presenting…
- Trial name
- Trauma AKI PPI (NCT06531642)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 2 days, Protonix (pantoprazole) 40 mg q 24 hrs for 2 days
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Hemorrhagic Shock, Traumatic Injury
Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in…
- Trial name
- TOWAR (NCT04684719)
- Testing
- low titer whole blood, Standard Care
- Where
- 10 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Jason Sperry
Haemorrhagic Shock, Trauma Coagulopathy
Implementation of an Empiric Transfusion Bundle for Out of Hospital Patients With Haemorrhagic Shock
The investigators will evaluate the implementation of a treatment bundle (Fibrinogen, Plasma and Tranexamic Acid)
- Trial name
- C-TOP (NCT06891131)
- Where
- Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Graz
Hemorrhagic Shock, Trauma
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy…
- Conditions
- Hemorrhagic Shock, Trauma, Exsanguinating Hemorrhage, Shock; Traumatic
- Trial name
- REVIVE (NCT02880163)
- Testing
- ResQFoam
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Arsenal Medical, Inc.
Hemorrhage, Hemorrhagic Shock
Optimization Strategies for Blood Transfusion Protocols in the Emergency Treatment of Hemorrhagic Shock
This single-center, prospective, randomized controlled trial was approved by the institutional ethics committee and overseen by an independent data and safety monitoring board.
- Conditions
- Hemorrhage, Hemorrhagic Shock, Upper Gastrointestinal Bleeding (UGIB)
- Trial name
- NCT07129031
- Testing
- low-titer O-group whole blood, 1:1:1 component transfusion, ABO- and Rh-compatible whole blood
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xijing Hospital