Clinical trials: Heterotopic Ossification
Elbow Trauma Requiring Operative Management
Indomethacin Prophylaxis for Heterotopic Ossification After Surgical Treatment of Elbow Trauma
Patients who present to our institution with a traumatic injury to their elbow who need operative management will be randomized to one of two groups; a treatment arm and a control arm.
- Trial name
- NCT01744314
- Testing
- Indomethacin and Pantoprazole, microcrystalline cellulose powder tablets
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Systemic Sclerosis, Dermatomyositis
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study
Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare.
- Conditions
- Systemic Sclerosis, Dermatomyositis, iPPSD2
- Trial name
- ITS-PILOT (NCT03582800)
- Testing
- STS
- Where
- 11 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Elbow Fracture, Neurologic Deficits
Fracture and Neurological Injury
The goal of the project is to describe novel factors affecting outcome after elbow fracture surgery with an in-depth evaluation of the role played by neuro inflammation from concomitant peripheral nerve injury or head injury in…
- Trial name
- FIRE (NCT05075382)
- Testing
- Elbow surgery for fracture
- Sponsor
- Université de Montréal
Heterotopic Ossification
Assessment of Heterotopic Ossification of Elbow Joint in Relation of Serum Uric Acid.
Heterotopic ossification (HO) is a common complication after surgical repair of elbow trauma. Uric acid is the end-product of purine metabolism that has any physiological and pathogenic potential functions.
- Trial name
- NCT03925688
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ossification, Heterotopic
Prevention of Heterotopic Ossification With Arcoxia After Total Hip Replacement
The purpose of the study is to determine whether Arcoxia is effective in preventing heterotopic ossification after total hip arthroplasty.
- Trial name
- Arcoxia (NCT01022190)
- Testing
- Etoricoxib (Arcoxia)
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Radboud University Medical Center
Ossification of the Posterior Longitudinal Ligament
A Prospective Study Comparing the Efficacy of Laminoplasty and Laminectomy With Fusion for Ossification of the Posterior Longitudinal Ligament With High Occupation Rate in Cervical Spine
The efficacy of laminoplasty and laminectomy with fusion for ossification of the posterior longitudinal ligament with high occupation rate in the cervical spine is not clear in the literature report so far.
- Trial name
- NCT05019001
- Testing
- Laminoplasty, Laminectomy With Fusion
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Cervical Myelopathy, Ossification of Posterior Longitudinal Ligament in Cervical Region
The Establishment of the Integration of Surgery and Postoperative Intensive Recovery of Patients With CSM
This study aims to establish the specialist consensus of the integration of posterior approach surgical treatment and postoperative intensive recovery management for CSM or OPLL patients, and verify its safety, practicability and…
- Trial name
- NCT04947891
- Testing
- Intensive recovery management
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Femoral Neck Fractures, Hemiarthroplasty
Uncemented Hemiarthroplasty, Radiological Features Comparing Lateral Versus Anterolateral Approach
Uncemented Hemiarthroplasty, Radiological Features Comparing Lateral Versus Anterolateral Approach. Comparing leg length discrepancy, femoral offset, valgus/varus position of the stem.
- Conditions
- Femoral Neck Fractures, Hemiarthroplasty, Heterotopic Ossification
- Trial name
- NCT03974698
- Testing
- Hemiarthroplasty
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sorlandet Hospital HF
Acetabular Fracture, Heterotopic Ossification
Heterotopic Ossification Prophylaxis
One complication that can occur after surgery on the acetabulum is the development of bone in abnormal places such as muscle and soft tissues.
- Trial name
- NCT04867278
- Testing
- External Beam Radiation (XRT), Debridement
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Maryland, Baltimore
Hip Osteoarthritis, Heterotopic Ossification
Balance in Patients With Ectopic Bone Tissue After Total Hip Replacement
One of the typical complications which occurs after total hip replacement (THR) procedure is heterotopic ossification (HO). According to current studies abnormal formation of bone after trauma or replacement of the hip could…
- Conditions
- Hip Osteoarthritis, Heterotopic Ossification, Hip Arthropathy
- Trial name
- NCT05218954
- Testing
- Biomechanical analysis of risk fall
- Where
- Poland
- Volunteers
- 88 people
- Sponsor
- Medical University of Warsaw
Heterotopic Ossification
Early Ultrasound Screening of Heterotopic Ossification After Severe Neurological Trauma
Prospective, bi-centric diagnostic, performance study on a new diagnostic procedure with ultrasounds against a reference diagnostic procedure.
- Trial name
- POHER II (NCT04934332)
- Testing
- Ultrasound, CT scan, Clinical examination
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heterotopic Ossification
Defining the Pathophysiology of Heterotopic Ossification: A Prospective Study
Our overarching aim is to define the pathophysiology, epidemiology, and natural history of HO by following patients from date of injury until full wound healing has occurred and the window for HO has passed.
- Trial name
- NCT04867018
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Ossification Posterior Longitudinal Ligament, Cervical Spondylotic Myelopathy
Comparison of IONM Between Remimazolam and Propofol
Inhalation anesthetics significantly can delay latency and reduce amplitude of cortical MEPs and SSEPs signals compared to intravenous anesthetics by acting on not only GABA (γ-aminobutyric acid) receptors but also NMDA…
- Trial name
- NCT04968054
- Testing
- Arm I (Propofol), Arm II (Remimazolam)
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Fibrodyplasia Ossificans Progressiva (FOP), Heterotopic Ossification (HO)
Study to Assess the Efficacy and Safety of Garetosmab in Japanese Adult Patients With Fibrodysplasia Ossificans Progressiva (FOP)
The primary safety objective of the study is to assess the safety and tolerability of garetosmab in Japanese male and female adult patients with FOP.
- Trial name
- NCT04577820
- Testing
- garetosmab
- Sponsor
- Regeneron Pharmaceuticals
Ossification, Heterotopic
Celecoxib for Primary Prophylaxis of Combat-Related Heterotopic Ossification
Hypotheses: H1: Celecoxib, when given less than five days after injury will result in a statistical decrease in the incidence and/or severity of radiographically apparent Heterotopic Ossification when compared to controls.
- Trial name
- NCT01631669
- Testing
- Celecoxib
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Walter Reed National Military Medical Center
Heterotopic Ossification, Humeral Fractures
HO Prophylaxis Therapy for Distal Humerus Fractures
To determine the effectiveness of 500 cGy dose of radiation therapy vs. an untreated group in the prophylactic treatment of heterotopic ossification in distal humerus fractures
- Conditions
- Heterotopic Ossification, Humeral Fractures, Radiation Therapy
- Trial name
- NCT03724422
- Testing
- Radiation
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- University of Louisville
Traumatic Brain Injury, Spinal Cord Injuries
Continuous Passive Motion Versus Heterotopic Ossification
The investigators hypothesize that Heterotopic Ossification (HO) formation can be suppressed if the application of a Continuous Passive Motion (CPM) device can be performed for a substantial amount of time.
- Conditions
- Traumatic Brain Injury, Spinal Cord Injuries, Stroke
- Trial name
- CPMversusHO (NCT05906056)
- Testing
- Continuous Passive Motion (CPM), Conventional physiotherapy (PT), Zoledronic Acid Injection
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Ioannina
Fibrodysplasia Ossificans Progressiva
An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP)
Fibrodysplasia Ossificans Progressiva (FOP) is a rare, severely disabling disease characterized by heterotopic ossification (HO), i.e., abnormal bone formation, often associated with painful, recurrent episodes of soft tissue…
- Trial name
- NCT02279095
- Testing
- Palovarotene dose level 1, Palovarotene dose level 2, Palovarotene dose level 3
- Where
- 8 sites in United States, Argentina and 3 more
- Volunteers
- 58 people
- Sponsor
- Clementia Pharmaceuticals Inc.
Ossification of Posterior Longitudinal Ligament, Cervical Spondylosis With Myelopathy
Multi-centre Study to Evaluate ACAF Versus Laminoplasty in Treating Cervical Ossification of the Posterior Longitudinal Ligament
The purpose of this study is to compare the efficacy, safety and imaging outcomes between Anterior Controllable Antedisplacement and Fusion (ACAF) and Laminoplasty in the treatment of severe ossification of cervical posterior…
- Trial name
- NCT04968028
- Testing
- ACAF, Laminoplasty
- Where
- 12 sites in China
- Volunteers
- 167 people
- Sponsor
- Shanghai Changzheng Hospital
Heterotopic Ossification (HO)
A Study of Andecaliximab in People With Spinal Cord Injury at Risk for Bone Growth Outside of the Normal Skeleton.
This is an open-label study of andecaliximab in participants at risk of developing bone where bone should not be, such as in muscle, tendons, and other soft tissues following traumatic spinal cord injury.
- Trial name
- ANDECA-HO (NCT07024407)
- Testing
- Andecaliximab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ashibio Inc