Clinical trials: High Energy Trauma
Cardiac Valve Disease, Coronary Artery Disease
The PRE-OP ENERGY Trial
The PRE-OP ENERGY Trial proposes to test the overarching hypothesis that a pre-surgery high energy diet will protect patients against organ damage during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- NCT04015973
- Testing
- High energy diet
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Leicester
Post-traumatic; Arthrosis, Tibial Fractures
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis.
- Conditions
- Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
- Trial name
- NCT05652881
- Testing
- Joint Lavage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Limb Salvage, Braces
The IM ABLE Study: A Study of Warriors & Veterans Following Neuromusculoskeletal Injury of the Lower Limb
The purpose of the IM ABLE(Injuries Managed with Advanced Bracing for Lower Extremities) study is to determine if advanced (ADV) ankle foot orthoses (AFOs) will enable users to achieve greater levels of physical and self-reported…
- Conditions
- Limb Salvage, Braces, Lower Extremity
- Trial name
- NCT03107728
- Testing
- Advanced orthotic brace, Conventional orthotic brace
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of South Florida
Trauma, Posttraumatic Stress Disorder
Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-01 Study
The purpose of this study is to evaluate the efficacy and safety of Polyunsaturated Fatty Acid for the prevention of Posttraumatic Stress Disorder (PTSD) in patients with accidental injuries.
- Trial name
- NCT00671489
- Testing
- Omega-3 Polyunsaturated Fatty Acid
- Where
- Japan
- Volunteers
- 15 people
- Sponsor
- Japan Science and Technology Agency
Muscle Tear
Effects of High Intensity Laser Therapy in Muscle Injuries
Muscle injuries are frequent traumatic events in daily life, particularly during sports. In sports, their incidence varies from 10% to 55% of total injuries.
- Trial name
- THEALinMJ (NCT06812611)
- Testing
- High Energy Laser Group, Exercise
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Surgical Site Infection
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
The purpose of this study is to see whether applying povidone iodine (PVI) to the noses of patients undergoing lower extremity (leg, ankle, or foot) orthopedic fixation procedures of high-energy lower extremity fractures (HELEF)…
- Trial name
- POTENT (NCT05763602)
- Testing
- povidone-iodine topical ointment
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Loreen Herwaldt
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Thumb Osteoarthritis, Hand Injuries
High-Energy Laser in the Conservative Treatment of Rhizarthrosis
Osteoarthritis (OA) is a degenerative joint disease that can affect the hands and is particularly debilitating when it involves the trapeziometacarpal joint (rhizarthrosis).
- Conditions
- Thumb Osteoarthritis, Hand Injuries, Laser, Exercise
- Trial name
- HLEX-TO (NCT07566507)
- Testing
- THEAL:Ixyon XP (Mectronic, Bergamo, Italy)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Trauma, Posttraumatic Stress Disorder
Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-02 Study
The purpose of this study is to evaluate efficacy and safety of Polyunsaturated Fatty Acid for the prevention of Posttraumatic Stress Disorder (PTSD) in patients with accidental injuries.
- Trial name
- NCT00671099
- Testing
- Omega-3 Polyunsaturated Fatty Acid
- Where
- Japan
- Volunteers
- 110 people
- Sponsor
- Japan Science and Technology Agency
Orthopaedic Fractures
Improving Pain Management and Long Term Outcomes Following High Energy Orthopedic Trauma (Pain Study)
The purpose of this study is to definitively resolve questions regarding the use of multimodal pharmacologic pain management for orthopedic trauma patients in the context of a multicenter, randomized clinical trial.
- Trial name
- PAIN (NCT01789216)
- Testing
- NSAID, Gabapentinoids
- Where
- 17 sites in United States
- Volunteers
- 450 people
- Sponsor
- Major Extremity Trauma Research Consortium
Trauma Injury
Bioimpedance for Ortho Trauma
Patients with high-energy extremity trauma will undergo imaging with an EIT device in the Emergency Department, Operating Room, Orthopaedic Clinic, and In-patient hospital rooms.
- Trial name
- NCT06858488
- Testing
- Extremity Surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Achilles Tendinitis, Tendinopathy
Clinical Trial to Evaluate the Adjuvant Effect of Shock Wave Therapy in the Insertional Achilles Tendinopathy
Background: There is no consensus regarding the treatment of insertional tendinopathies. The good results of the eccentric training in the management of the non-insertional Achilles tendinopathy were not reproducible in the…
- Trial name
- NCT02757664
- Testing
- Shock Wave Therapy, Eccentric Exercises
- Where
- Brazil
- Volunteers
- 119 people
- Sponsor
- Federal University of São Paulo
Metabolism, Trauma
ImpACt of Very High Protein Content Enteral nUtrition Formulas on Critically Ill MUltipLe trAuma paTiEnts
This prospective observational randomized study aims to determine energy, protein intake and gastrointestinal tolerance while using enteral nutrition formulas with very high protein content and enteral nutrition formulas with…
- Conditions
- Metabolism, Trauma, Nutritional Deficiency, Protein Malnutrition
- Trial name
- ACCUMULATE (NCT05647135)
- Testing
- Medical food
- Where
- Romania
- Volunteers
- 70 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Lateral Epicondylitis, Tennis Elbow
Corticosteroid Injection Verses High Energy Extracorporeal Shock Wave Therapy for Lateral Epicondylitis
The purpose of this study is to prospectively compare the pain and functional outcomes of patients with chronic lateral epicondylitis treated with either intratendinous corticosteroid injection or high energy extracorporeal shock…
- Trial name
- NCT02613455
- Testing
- extracorporeal shock wave therapy, Kenalog (triamcinolone), lidocaine 1% (lidocaine HCl 20mg)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Trauma Injury
Placebo Versus Oxandrolone Supplementation in Trauma
The primary aim of this study is to examine the effect of Oxandrolone supplementation after lower extremity high energy fracture on muscle volume recovery.
- Trial name
- NCT05516849
- Testing
- Oxandrolone
- Sponsor
- Sunnybrook Health Sciences Centre
Compartment Syndromes, Compartment Syndrome of Lower Leg
NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome
This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and…
- Conditions
- Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm
- Trial name
- NCT05672381
- Testing
- Lower extremity and/or upper extremity surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Abdominal Injuries, Thoracic Injuries
Robot-based Tele-echography II - A Comparative Study
The aim of this clinical trial is to evaluate the concordance of diagnosis of injuries in thoracoabdominal trauma using two different echographic methods.
- Conditions
- Abdominal Injuries, Thoracic Injuries, High Energy Trauma
- Trial name
- NCT00295438
- Testing
- Robot-Based Tele-Echography (TER), ultrasound method FAST
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Grenoble
Trauma Injury
SFDI in High Energy Lower Extremity Fracture
This is a non-randomized prospective study of 20 patients with high energy lower extremity fractures evaluating feasibility and acceptability of SFDI, a real-time optical imaging technology.
- Trial name
- NCT05635617
- Testing
- Lower Extremity Surgery
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Health, Subjective, Nutrition Disorders
Relative Energy Deficiency in Sport Multicenter Study
Relative Energy Deficiency in Sport (RED-S) characterizes a range of negative health and performance outcomes that result from chronically low energy availability.
- Conditions
- Health, Subjective, Nutrition Disorders, Athletic Injuries, Hormone Disturbance
- Trial name
- NCT04766203
- Testing
- Treatment of REDS using a holistic treatment arm
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Trent Stellingwerff
Trauma Injury
ICG Fluorescence Imaging in Open Fracture Trauma Patients
This is a prospective observational study that will evaluate the association between bone and tissue perfusion, as measured by indocyanine green (ICG) fluorescence imaging, and complications, in an effort to develop ICG…
- Trial name
- NCT04416412
- Testing
- Immunofluorescence Imaging
- Where
- 4 sites in United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center