Clinical trials: High-Flow Nasal Cannula
Respiratory Disease (Clinically Stable Individuals - Patients Recovered From Respiratory Disease)
The Effect of Asymmetrical vs. Symmetrical High Flow Nasal Cannula on the Work of Breathing
The goal of this study randomized single-center crossover study is to evaluate the impact of asymmetrical versus symmetrical nasal high flow (NHF) therapy on work of breathing (WOB). The main question it aims to answer are: 1.
- Trial name
- NCT07066566
- Testing
- Asymmetric nasal cannula - DUET, Conventional nasal high flow cannula
- Where
- Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Larissa University Hospital
Preterm Birth
Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support.
Oxygen treatment is common in babies born early (preterm) and requiring intensive care. Having too much or too little oxygen can increase the risk of damage to the eyes and lungs, and contribute to death or disability.
- Trial name
- ROAM (NCT04687618)
- Testing
- High Flow Nasal Cannula withAutomatic control of FiO2 using OAM, High Flow Nasal Cannula with manual control of FiO2
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Respiratory Failure, Hypoxemic Respiratory Failure
Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure
First-line therapy of patients with acute respiratory failure consists in oxygen delivery through standard oxygen, high-flow nasal oxygen therapy through cannula or non-invasive ventilation.
- Trial name
- SOHO (NCT04468126)
- Testing
- Standard oxygen, High-flow nasal oxygen therapy
- Where
- France
- Volunteers
- 1,504 people
- Sponsor
- Poitiers University Hospital
Pneumonia
Oxygen Therapy for Children With Moderate Hypoxemia in Malawi
The goal of this pilot clinical trial is to compare standard of care, low-flow oxygen, and high-flow nasal canula oxygen in pediatric patients aged 1-59 months with pneumonia and an oxygen saturation of 90-93% in Malawi.
- Trial name
- NoGoLo2 (NCT06176664)
- Testing
- Low flow oxygen, High-flow nasal cannula oxygen
- Where
- Malawi
- Volunteers
- 21 people
- Sponsor
- Johns Hopkins University
Corona Virus Infection
Clinical Characteristics and In-hospital Death of a Chilean COVID-19 Prospective Cohort
The investigators planned to examine a cohort of admitted patients at University of Chile Clinical Hospital with COVID-19 diagnosis.
- Trial name
- NCT04758039
- Where
- Chile
- Volunteers
- 395 people
- Sponsor
- University of Chile
Obstructive Sleep Apnea
High Flow Nasal Cannula Therapy for Childhood OSA
The main objective of this study is to evaluate the efficacy of high-flow nasal cannula (HFNC) therapy in children with OSA. Children and adolescents aged 6 to 18 years old with a diagnosis of moderate-to-severe OSA requiring…
- Trial name
- NCT03933800
- Testing
- High flow nasal cannula, Continuous positive airway pressure
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong
Aortic Stenosis, Sedation Complication
High Flow Nasal Oxygen Cannula in Transcatheter Aortic Valve Replacement: Complications and Biomarkers
Background Transcatheter aortic valve replacement is a risky procedure, performed in patients that can also be considered at risk of developing complications.
- Trial name
- HIGH-OXY-TAVR (NCT05958537)
- Testing
- High flow nasal oxygen
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Clinic of Barcelona
Bronchoscopy
Three Different Oxygenation Strategies in Bronchoscopy Procedures Under Sedation
The purpose of study aims to determine which of the three different oxygenation strategies, including nasal cannula, modified nasopharyngeal cannula, and HFNO groups, is safer in patients undergoing bronchoscopy under sedation.
- Trial name
- NCT05912985
- Testing
- different oxygenation methods
- Where
- Turkey (Türkiye)
- Volunteers
- 252 people
- Sponsor
- Ankara City Hospital Bilkent
Apneic Oxygenation
Apneic Oxygenation in the Emergency Department
Apneic oxygenation is a process of delivering continuous oxygen during direct laryngoscopy. Nasal cannulas are used for the purpose of oxygenation; for delivering either low flow or high flow oxygen but haven't been tested in…
- Trial name
- ApOxED (NCT04242537)
- Testing
- High flow nasal cannula oxygen delivery, Low flow nasal cannula oxygen delivery
- Volunteers
- 30 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Apneic Oxygenation
The Efficacy of Transnasal Humidified Rapid-insufflation Ventilatory Exchange During Laryngeal Microsurgery
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) was revealed to prolong apneic time with a slow increase in carbon dioxide; thus, has been used for preoxygenation in patients with difficult airways or…
- Trial name
- NCT03629353
- Testing
- endotracheal intubation, high flow nasal cannula
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Hospital
Swallowing Disorder, Respiratory Insufficiency
The Impact of High-Flow Nasal Cannula on Swallow Function
Background: High-flow nasal cannula (HFNC) is a non-invasive heated and humidified oxygen delivery device that is capable of delivering high-flow rates.
- Trial name
- NCT03590457
- Testing
- Airvo 2; High-Flow nasal cannula system
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Acute Respiratory Failure
Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF
The goal of this clinical trial is to determine whether one of the two oxygenation or ventilation strategies (NIV and/or HFNO) is superior to standard oxygen to reduce 28-day mortality rate in hypoxemic acute respiratory failure…
- Trial name
- KISS (NCT05812911)
- Testing
- Standard oxygen, HFNO, NIV
- Where
- France
- Volunteers
- 1,470 people
- Sponsor
- University Hospital, Montpellier
High Flow Nasal Cannula, Oxygen Therapy
Closed-loop Oxygen Control for High Flow Nasal Therapy
In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decrease work of breathing as compared to standard oxygen therapy by facemask.
- Conditions
- High Flow Nasal Cannula, Oxygen Therapy, Hypoxemia, Hyperoxemia
- Trial name
- HILOOP (NCT04965844)
- Testing
- Oxygen close-loop, No intervention
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hypoxia, Gastric Cancer
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity
Hypoxia is the most common adverse event during gastrointestinal endoscopes sedated with propofol and sufentanil, especially in obese people.
- Conditions
- Hypoxia, Gastric Cancer, Esophagus Cancer, Polyp of Colon
- Trial name
- NCT04500392
- Testing
- High-flow nasal cannula oxygenation, Regular nasal cannula
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- RenJi Hospital
Postoperative Hypoxemia
Optiflow® to Prevent Post-Extubation Hypoxemia afteR Abdominal Surgery (the OPERA Trial)
To evaluate whether early application of nasal high flow oxygen therapy after extubation can reduce the incidence of postoperative hypoxemia (defined as a PaO2/FiO2 ratio <300) after abdominal surgery in patients with…
- Trial name
- OPERA (NCT01887015)
- Testing
- Nasal high flow cannula (OptiflowTM, MR850 heated humidified, Fisher & Paykel Healthcare, Auckland, New Zealand)
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Clermont-Ferrand
COPD Exacerbation
Heated High Humidity After COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease usually caused by exposure to tobacco smoke which leads to chronic symptoms of shortness of breath, cough, and phlegm.
- Trial name
- NCT03772626
- Testing
- Heated Humidified High-flow Nasal Cannula
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Prone Positioning, High Flow Nasal Cannula
Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and had subsequently spread worldwide. Twenty-nine percent of COVID-19 patients may develop ARDS.
- Conditions
- Prone Positioning, High Flow Nasal Cannula, Acute Respiratory Distress Syndrome, Corona Virus Infection
- Trial name
- NCT04325906
- Testing
- high flow nasal cannula (HFNC), Prone positioning (PP)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Rush University Medical Center
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Respiratory Insufficiency, Respiratory Failure
High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure
RENOVATE study aims to investigate if the respiratory support device called High-Flow Nasal Oxygen Cannula (HFNC) acts similarly (non-inferior) to another respiratory support device called Non-Invasive positive-pressure…
- Trial name
- RENOVATE (NCT03643939)
- Testing
- High Flow Nasal Catheter, Noninvasive ventilation
- Where
- Brazil
- Volunteers
- 1,801 people
- Sponsor
- Hospital do Coracao