Clinical trials: High-Flow Nasal Cannula
Post Extubation Respiratory Failure
The Effectiveness of High-flow Nasal Cannula After Extubation in Patients
Observe the current status of prolonged mechanical ventilation (PMV) patients using high-flow nasal cannula oxygen therapy (experimental group) or traditional oxygen therapy (control group) after extubation, and compare the…
- Trial name
- NCT06746363
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- Chang Gung Memorial Hospital
Anesthesia, General, Apnea
High-flow Nasal Oxygenation for Open Mouth
This study aims to evaluate the effect of high-flow nasal oxygenation on safe apnea time for children undergoing general anesthesia, with their mouth open.
- Trial name
- NCT04290728
- Testing
- Apnea with high-flow nasal cannula, Apnea
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Seoul National University Hospital
Obesity, Morbid
Preoxygenation With Optiflow™ in Morbidly Obese Patients is Superior to Face Mask
Optiflow™ may provide an opportunity to prolong apnea time in the morbidly obese patient population. This study will examine whether Optiflow can do this, and compare the pre-oxygenation with Optiflow to the pre-oxygenation…
- Trial name
- NCT03009877
- Testing
- Optiflow F&P 850™ System, facemask, Rocuronium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Infant, Premature, Neonatal Respiratory Distress
Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants
Oxygen treatment is common in management of preterm babies requiring intensive care. Delivery of too much or too little oxygen increase the risk of damage to eyes and lungs, and contributes to death and disability.
- Conditions
- Infant, Premature, Neonatal Respiratory Distress, Oxygen Saturation, Bronchopulmonary Dysplasia
- Trial name
- MODERATION Neo (NCT05030012)
- Testing
- Automated Control, Manual Control
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Vapotherm, Inc.
Diaphragm Injury, Postoperative Complications
High Flow Nasal Cannula and Diaphragmatic Function
Prospective randomized study investigating the effect of postoperative oxygen delivery on diaphragmatic function. Two different modalities of oxygen delivery will be compared: high flow nasal cannula versus standard oxygen…
- Trial name
- NCT05532033
- Testing
- High flow nasal cannula, Facial mask
- Where
- Italy
- Volunteers
- 116 people
- Sponsor
- Università degli Studi di Ferrara
Bronchoscopy
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) and Diagnostic Bronchoscopy
The purpose of this study is to investigate whether diagnostic bronchoscopy can be safely and potentially more effectively performed without the use of tracheal intubation or a supraglottic airway, under completely unobstructed…
- Trial name
- NCT03086408
- Testing
- THRIVE, Endotracheal tube or Supraglottic airway
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Acute Hypercapnic Respiratory Failure, Acute Exacerbation of COPD
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure
Chronic lung conditions such as smoking related lung damage lead to breathing fail. This results in accumulation of gases such as carbon-di-oxide in the body especially during periods of illness known as exacerbation.
- Trial name
- NCT04640948
- Testing
- High flow nasal therapy, Low flow oxygen
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- Belfast Health and Social Care Trust
Status Asthmaticus
High Flow Nasal Cannula in Children With Status Asthmaticus
In France, over 2.5 million people suffer from asthma, including one-third of children. This is the chronic respiratory disease leading to the highest rate of hospitalization.
- Trial name
- CANULASTHM (NCT03157102)
- Testing
- HFNC, Standard Oxygen Treatment
- Where
- 14 sites in France
- Volunteers
- 272 people
- Sponsor
- Hospices Civils de Lyon
Bronchoscopy,Oxygen
Modified HFNC Oxygen in Patients Undergoing Bronchoscopy.
The purpose of this study is to determine whether the Modified High-flow nasal cannula is effective in the oxygen of the patients undergoing bronchoscopy.
- Trial name
- NCT02606188
- Testing
- Modified High-flow nasal cannula, nasal cannula
- Where
- China
- Volunteers
- 812 people, healthy volunteers welcome
- Sponsor
- Haichao Li
Premature Birth, Respiratory Distress Syndrome
Comparison of the Results of Transcutaneous Carbon Dioxide and Oxygen Pressure in Premature Neonates Who Underwent MIST Under HHHFNC or Nasal CPAP Methods
Intratracheal surfactant treatment is applied in Respiratory Distress Syndrome (RDS) Continious Positive Airway Pressure(CPAP) treatment.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- TCOPHC (NCT04505176)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Hacettepe University
Acute Respiratory Failure
High Flow Therapy for the Treatment of Respiratory Failure in the ED
The overall objective of this study is to determine if Vapotherm high flow nasal cannula therapy (HFT), when used to treat respiratory failure in the ED, is at least equivalent to the current standard of care for non-invasive…
- Trial name
- NCT02236559
- Testing
- Noninvasive positive pressure ventilation (NIPPV), Vapotherm
- Where
- 5 sites in United States
- Volunteers
- 204 people
- Sponsor
- Vapotherm, Inc.
Respiratory Failure With Hypercapnia, Therapeutic Bronchofiberoscopy
To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).
Background: Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes.
- Trial name
- NCT06970041
- Testing
- Use of NIV during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure, Use of HFNC during therapeutic FOB as a respiratory support method in patients with type 2 respiratory failure
- Volunteers
- 315 people
- Sponsor
- Medical University of Silesia
Hypoxemia
Therapy With High-flow Oxygen by Nasal Cannula vs Noninvasive Ventilation in Patients With Acute Hypoxemic Respiratory Failure: a Crossover Physiologic Study
Background and rationale: A large multicenter randomized controlled trial demonstrated that in patients with hypoxemic non-hypercapnic respiratory failure treatment with nasal high flow oxygen (NHF) resulted in a reduction of the…
- Trial name
- THIFON (NCT03865056)
- Testing
- Optiflow (High-flow Nasal Cannula), Non-invasive Ventilation
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Bronchiolitis, Heliox
Helium-oxygen Gas Mixtures Delivered by a High Flow Nasal Cannula in Bronchiolitis
The aim of this prospective pilot study is to determine the effect of heliox delivered via a proprietary calibrated heated and humidified high flow nasal cannula (HFNC) system (Vapotherm Precision Flow Heliox) in children ages…
- Conditions
- Bronchiolitis, Heliox, Pediatrics
- Trial name
- NCT02373683
- Testing
- Vapotherm-Heliox
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Western Reserve University
Hypoxia, Gastric Cancer
High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Gastroscopy Sedated by Propofol
Hypoxia is the most common adverse events during sedated gastroscopy. In present study, high-flow nasal cannula oxygenation will be utilized in order to reduce the hypoxia.
- Conditions
- Hypoxia, Gastric Cancer, Esophagus Cancer, Adverse Event
- Trial name
- HONCHO (NCT03332433)
- Testing
- High-flow nasal cannula oxygenation
- Where
- 3 sites in China
- Volunteers
- 2,034 people
- Sponsor
- RenJi Hospital
COVID-19, Acute Respiratory Failure
High Frequency Percussive Ventilation in COVID-19 Patients
High frequency percussive ventilation (HFPV) is used in patients with underlying pulmonary atelectasis, excessive airway secretions, and respiratory failure.
- Trial name
- NCT05358184
- Testing
- High frequency Percussive ventilation
- Volunteers
- 15 people
- Sponsor
- University Magna Graecia
Upper Airway Obstruction, Apnea, Obstructive
Improve Oxygenation and Capnographic Detection During Sedative EGD
The purpose of this study is to compare the effect of mandibular advancement bite block and high flow nasal cannula to standard bite block for oxygenation, capnographic measurement, prevention of hypoxemia, intervention events…
- Trial name
- NCT03138850
- Testing
- Olympus standard bite block, YX mandibular advancement bite block, Optiflow High flow nasal cannula
- Where
- Taiwan
- Volunteers
- 170 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Cardiogenic Pulmonary Edema, Hypercapnic Respiratory Failure
High Flow Nasal Cannula Therapy for Early Management of Acute Hypercapnic Cardiogenic Pulmonary Edema in the Emergency Department
High flow nasal therapy (HFNT) has not been well evaluated for treating hypercapnia The purpose of this study is to determine whether high flow nasal therapy (HFNT) can decrease hypercapnia and improve respiratory distress…
- Trial name
- preopticap (NCT03883555)
- Testing
- High flow nasal therapy (HFNT) : Optiflow™, Non invasive ventilation (niv)
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Montpellier
Respiratory Distress Syndrome
Effect of High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure
Respiratory distress syndrome (RDS) in preterm babies is caused by a deficiency of lung surfactant. The risk of RDS increases with decreasing gestational age, and is almost inevitable in babies born at less than 28 weeks…
- Trial name
- NCT05849116
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome
High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome
To compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated…
- Trial name
- NCT02587832
- Testing
- HHHFNC, NCPAP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidra Medicine