Clinical trials: Hopefulness
Heart Failure With Normal Ejection Fraction
Inhaled Iloprost and Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction
BACKGROUND There is no effective medical treatment for heart failure with preserved ejection fraction (HFpEF). Increases in pulmonary capillary wedge pressure (PCWP) develop in patients with HFpEF.
- Trial name
- ILO-HOPE (NCT03620526)
- Testing
- Iloprost
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Substance Use, Criminal Recidivism
HOPE Demonstration Field Experiment Multisite Evaluation
The purpose of the Multisite Evaluation of the Honest Opportunity Probation with Enforcement Demonstration Field Experiment (the HOPE DFE Evaluation) is to conduct a randomized control trial (RCT) replication of the original…
- Trial name
- NCT01670708
- Testing
- HOPE, Probation as Usual
- Where
- 4 sites in United States
- Volunteers
- 1,504 people, healthy volunteers welcome
- Sponsor
- RTI International
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
COVID-19
ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease
Albertans with COVID-19 are at risk of deteriorating and developing severe illness. Those over age 40 or with co-morbid illness, and likely those who are immune suppressed, are at highest risk.
- Trial name
- NCT04329611
- Testing
- Hydroxychloroquine
- Where
- 2 sites in Canada
- Volunteers
- 148 people
- Sponsor
- Dr. Michael Hill
Hemoadsorption, Vasopressor Therapy
Hemodynamic, Laboratory, and Clinical Outcomes of Hemoadsorption Therapy
This single-center retrospective observational cohort study aims to evaluate the clinical, hemodynamic, and laboratory effects of adjunctive hemoadsorption therapy in critically ill adult patients treated in the Intensive Care…
- Trial name
- HOPE-FUL (NCT07679555)
- Testing
- Hemoadsorption
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Pest County Flór Ferenc Hospital
Knee Osteoarthritis
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis
The aim of this trial is to conduct a 12-week randomised controlled trial comparing an HRV-guided home exercise program with traditional home exercise program for individuals with knee osteoarthritis (KOA), followed by 24-week…
- Trial name
- HOPE-OA (NCT07391449)
- Testing
- HRV-guided home exercise prescription, Traditional Home Exercise
- Where
- Hong Kong
- Volunteers
- 240 people
- Sponsor
- The Hong Kong Polytechnic University
Depression, Anxiety
The 28 Day Challenge
The purpose of this study is to determine how a 28 Day Challenge influences mental health and well-being. This is a blinded study. Participants both with and without depression and anxiety, will be included.
- Conditions
- Depression, Anxiety, Stress, Hope
- Trial name
- NCT03936946
- Testing
- Audio Content 1, Audio Content 2
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Stanford University
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Psychological Distress (Depression, Anxiety and Stress) Cancer
Efficacy of an Integrated Psychological Interventions Combined With Ar_Rahman Listening for Reducing Psychological Distress and Enhancing Hope and Quality of Life Among Cancer Patients: A Randomized Controlled Trial
This is a randomized control trial(RCT ID:25142101) to evaluate the efficacy of psychological intervention combined with listening to surah Ar- RAhman for reducing psychological distress and improving cancer patients' hope and…
- Trial name
- NCT07833982
- Testing
- supportive psychotherapy plus QURAN recitation9Surah Ar -Rahman
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfikar Ali Bhutto Institute of Science and Technology (SZABIST) University
HIV Infection, Liver Transplant
Expanding HOPE Liver
This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with an increased risk of opportunistic infection and cancer.
- Trial name
- NCT07778459
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
End Stage Liver DIsease, Liver Failure
VitaSmart HOPE System: Bridge to HOPE Registry
This is a post-market, multicenter, single-arm, observational registry evaluating real-world use of the VitaSmart HOPE System under standard of care conditions.
- Trial name
- NCT07578441
- Testing
- hypothermic oxygenated perfusion therapy of a donor liver under standard of care conditions
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Bridge to Life Ltd.
Pediatric
Posıtıve Psychology-Based Art Therapy In Hospıtalızed Chıldren
Pediatric hospitalization is known to be associated with negative developmental and psychosocial outcomes for child patients. Art therapy is a way to directly address the emotional world of hospitalized children.
- Trial name
- PP-ArtChild (NCT07735364)
- Testing
- Posıtıve Psychology-Based Art Therapy In Hospıtalızed Chıldren (PP-ArtChild)+Routine Pediatric Nursing Care, Routine Pediatric Nursing Care
- Volunteers
- 80 people
- Sponsor
- Suleyman Demirel University
Psychological Well-being, Hope Level
A Hope-Fostering Counseling Program to Promote Psychological Well-being Among Post-Abortion Primigravida Mothers: A Pilot Intervention Development and Feasibility Study
This study aims to investigate the feasibility of a hope-fostering counseling program among post-abortion primigravida mothers. The counseling program is composed of 6 counseling sessions based on individualized discussion.
- Conditions
- Psychological Well-being, Hope Level, Post-abortion, Hope Fostering Counseling Program
- Trial name
- NCT07488130
- Testing
- Hope-Fostering Counseling Program
- Where
- Jordan
- Volunteers
- 8 people
- Sponsor
- University of Jordan
Climate Change, Pregnancy
The Role of Climate Change Education on Awareness, Concern, and Hope in Pregnant Women
Climate change can negatively impact women's health at different stages of life through environmental risks such as extreme temperatures, vector-borne diseases, and air pollution.
- Trial name
- Climate Change (NCT07403513)
- Testing
- Climate Change Education
- Where
- Turkey (Türkiye)
- Volunteers
- 154 people
- Sponsor
- Saglik Bilimleri Universitesi
Pregnancy, Postpartum
Usability Study of Gestational and Postpartum Weight Management Program
The principal aim of this study is to evaluate the usability of the Hope-D gestational and 6 months postpartum weight management program.
- Conditions
- Pregnancy, Postpartum, Obese Pregnant Women, Weight Management
- Trial name
- Hope-D_Use (NCT07272824)
- Where
- Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Mental Health, Violence Against Children
Hope Groups: Parenting and Mental Health Among Refugees in the Middle East
This research is testing if 'Hope Groups' -- a psychosocial, mental health, parenting strengthening, and violence prevention support group program -- work to help Palestinian caregivers displaced by war.
- Trial name
- NCT07506421
- Testing
- Hope Groups
- Where
- Jordan
- Volunteers
- 490 people
- Sponsor
- University of Oxford
Lupus Nephritis (LN)
High Quality Evidence of Guangzhou Lupus Nephritis Cohort (HOPE Cohort)
The goal of this observational study is to learn about the long-term renal and patient's survival of lupus nephritis (LN) patients in China.
- Trial name
- HOPE (NCT06682507)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Spinal Cord Injury, Quadriplegia/Tetraplegia
Home-Based Digital Rehabilitation Program Optimized With Transcutaneous Spinal Cord Stimulation for Upper Limb Functional Enhancement in Tetraplegia (HOPE): A Safety, Efficacy, and Feasibility Study
Individuals with chronic cervical spinal cord injury (SCI) and tetraplegia commonly experience persistent impairment in upper limb function, leading to reduced independence and quality of life.
- Trial name
- HOPE (NCT07438353)
- Testing
- Home-based digital rehabilitation programme with tSCS
- Where
- Singapore
- Volunteers
- 9 people
- Sponsor
- Singapore General Hospital
Stroke, Sleep Apnea
Telemedicine Monitoring of Sleep Apnea in Stroke
Study Objectives: Meta-analyses report a high prevalence of moderate to severe sleep apnea of more than 50% in stroke patients, with adherence rates for CPAP therapy of only 30%.
- Trial name
- HOPES (NCT02748681)
- Testing
- Auto CPAP AirSense™ 10(Resmed)
- Where
- Austria
- Volunteers
- 34 people
- Sponsor
- Neurologisches Rehabiliationszentrum Rosenhügel
Human Immunodeficiency Virus, End Stage Renal Disease
Tulane Abdominal Transplant Institute (TATI) of Solid Organ Transplantation of HIV-Positive Recipients From HIV-Positive Donors
The U.S. Department of Health and Human Services (HHS), through the National Institutes of Health (NIH), published Final Human Immunodeficiency Virus (HIV) Organ Policy Equity (HOPE) Act Safeguards and Research Criteria for…
- Trial name
- NCT05159466
- Testing
- Kidney transplant
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tulane University