Clinical trials: Human Gastrointestinal Tract
Obesity, Type 2 Diabetes Mellitus
Effects of Obesity Treatments on Food Preferences and Metabolism
Obesity and Type 2 Diabetes Mellitus are major health problems which are becoming a burden both for patients and health systems alike.
- Trial name
- FPS (NCT01724060)
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cholestasis, Primary Sclerosing Cholangitis
Biliary Excretion of Conjugated Bile Acids in Humans Measured by 11C-cholylsarcosine PET/CT
We wish to develop a protocol for PET/CT examination of humans using the bile acid tracer 11C-cholylsarcosine. This is done by a series of PET/CT examinations of healthy humans and patients with cholestatic disorders.
- Conditions
- Cholestasis, Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis
- Trial name
- NCT01879735
- Testing
- 11C-CSar, ICG
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Sensitivity, Insulin Resistance
Effect of Yakult Ingestion on Diet-induced Insulin Resistance in Humans
Participants will be randomly allocated to either Yakult ingestion or a control group. For the first 20 days, subjects will consume their normal diet (keeping a detailed food diary throughout).
- Conditions
- Insulin Sensitivity, Insulin Resistance, Type 2 Diabetes Mellitus
- Trial name
- NCT03037918
- Testing
- Yakult light
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Human Gastrointestinal Physiology Data
Modernization of in vivo-in Vitro Oral Bioperformance Prediction and Assessment
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS Class IIa drug ibuprofen under…
- Trial name
- NCT02806869
- Testing
- Single dose of ibuprofen (800 mg tablet), Pulmocare, two 8.0 oz (236.6 mL) cans
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diphtheria, Hepatitis B
Pilot Study Freeze and Transport Immune Cells
To evaluate and standardize umbilical cord specimen collection and laboratory procedures to evaluate cellular and serological immune responses in neonates and young infants
- Conditions
- Diphtheria, Hepatitis B, Pertussis, Poliomyelitis
- Trial name
- NCT00138268
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID, Influenza
Innovative Tool to Limit Spread of COVID 19 in Residential Aged Care Facilities
This project is a randomised trial in order to determine if "gamification" can result in behaviour change for healthcare workers in the residential aged care setting.
- Conditions
- COVID, Influenza, Gastroenteritis
- Trial name
- NCT04377165
- Testing
- Gamification, Newsfeed function
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Gut Dysbiosis
A Clinical Study to Assess the Safety and Effectiveness of Test Product in Healthy Adult Human Subjects Having Symptoms of Gut Dysbiosis (Heart Burn, Bloating, Constipation and Gut Immunity).
This is prospective, open-label, single-arm, proof of science, clinical safety and efficacy study of MetProUltima in healthy adult human subjects having symptoms of Gut Dysbiosis (heart burn, bloating, constipation).
- Trial name
- NCT06572358
- Testing
- MetProUltima
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Healthy
Effects of a Diet Based on Inulin-rich Vegetables on Gut Health and Nutritional Behaviour in Healthy Humans
Inulin-type fructans (ITF) are fermentable dietary fibres that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behaviour is a matter of debate.
- Trial name
- NCT03540550
- Testing
- Diet based on inulin-rich vegetables
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Metabolism
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.
- Trial name
- NCT04255368
- Testing
- Water-soluble choline, Fat-soluble choline, No choline control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Utah State University
Gut Microbiota
Westlake Gut Microbiome Study
The Westlake Gut Microbiome study is a prospective cohort study. This project aims to characterize the gut microbiome among Chinese populations from different regions of China, and explore the relationships between gut microbiota…
- Trial name
- NCT04435548
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Diphtheria, Tetanus
Antibody Persistence in Healthy Children After Primary and Booster DTaP-IPV-Hep B-PRP-T Vaccine or Control Vaccine
The purpose of this study is to evaluate the long term immunogenicity produced in children by the investigational hexavalent vaccine (DTaP-IPV-Hep B-PRP-T) given in Study A3L15 (NCT 00362336).
- Conditions
- Diphtheria, Tetanus, Whooping Cough, Hepatitis B
- Trial name
- NCT01105559
- Where
- 2 sites in South Africa
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Sanofi
Mild Cognitive Impairment, Subjective Memory Impairment
The Cognitive Ageing Nutrition and Neurogenesis (CANN) Trial
There is a dearth of research which takes a multi-compound approach to dietary interventions, in humans, aimed at improving outcome measures of cognition.
- Trial name
- CANN (NCT02525198)
- Testing
- fatty acid/flavonoid blend
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Postoperative Ileus
Effect of TU-100 on Gastrointestinal and Colonic Transit in Humans
The purpose of this study is to compare the dose related effects of orally administered TU-100, a botanical agent that modulates gastrointestinal nerves, on gastrointestinal motility and colonic transit of solids.
- Trial name
- NCT00871325
- Testing
- Daikenchuto (TU-100)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tsumura USA
Cystic Fibrosis
Detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity in Rectal Tissues From Human Subjects
This is a pilot study. The purpose of the study is to facilitate the development of a new biomarker of cystic fibrosis transmembrane conductance regulator (CFTR) function using rectal tissue.
- Trial name
- NCT01078740
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Diphtheria, Hepatitis B
Pentavalent DTaP-Hep B-IPV
The purpose of this study is to evaluate the safety of administering a combination vaccine (DTaP-HepB-IPV; Pediarix™) to infants at birth, 2 and 6 months compared to the administration of a HepB vaccine at birth and the same…
- Conditions
- Diphtheria, Hepatitis B, Poliomyelitis, Pertussis
- Trial name
- NCT00133445
- Testing
- DTaP-Hep B-IPV Vaccine, Monovalent Hep B Vaccine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
A Study to Evaluate the Influence of Diet on GI Health
The purpose of this study is to understand the potential of protein and psyllium fiber to manipulate gut microbial densities, intestinal permeability, and inflammation in humans.
- Trial name
- NCT04783142
- Testing
- High-fiber, low-protein diet, Low-fiber, high-protein diet
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Human Microbiome
Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties
Pomegranate extract (Pomella) is well known for its antioxidant properties due to its phenolic compounds. It has also been shown to increase the amount of short chain fatty acid producing Lactobacillus and Bifidobacteria genera.
- Trial name
- NCT04596722
- Testing
- Pomella
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Obesity
Effects of Prebiotic-based Snacks on the Gut Microbiota and Perceived 'Satisfaction'
To determine the effects of prebiotic 'snacks' on gut health and satisfaction between meals
- Trial name
- NutriSAT (NCT02041975)
- Testing
- Nutriose FB06
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Reading
Diphtheria, Tetanus
Post-authorization Safety Study of Euforvac-Hib Vaccine for Active Primary Immunization in Infants From 6 Weeks
A multicenter, observational study to evaluate the safety of Euforvac-Hib vaccine for active primary immunization against diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenza type B in infants.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT02257645
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- LG Life Sciences
Diphtheria, Tetanus
Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine
A randomized phase IV study of the liquid pentavalent combination vaccine to evaluate the safety, immunogenicity (short term and long term) and clinical consistency of three production lots of the vaccine.
- Conditions
- Diphtheria, Tetanus, Pertussis, Hepatitis B
- Trial name
- NCT00877357
- Testing
- Shan 5
- Where
- India
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Shantha Biotechnics Limited