Clinical trials: Hypertonic Disorder
Neuromuscular Diseases, Neurodevelopmental Disorders
Nebulised Hypertonic Saline to Decrease Respiratory Exacerbations in Neuromuscular Disease or Neurodisability
Research Aim: This study investigates whether a 12-month treatment with hypertonic saline (salty water) can reduce antibiotic use in individuals with neuromuscular disease or cerebral palsy who frequently experience chest…
- Conditions
- Neuromuscular Diseases, Neurodevelopmental Disorders, Cerebral Palsy
- Trial name
- SPICE-UP (NCT06134401)
- Testing
- saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Nephropathy
The Effect of Thiazide, Amiloride and Hypertonic Saline on Urinary Biomarkers in Healthy Subjects
Urinary biomarkers (u-NKCC2, u-ENaC-gamma and u-AQP2) reflects the activity of the sodium- and water channels in the human kidney.
- Trial name
- THAM (NCT01635231)
- Testing
- hypertonic saline
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Allergic Rhinitis
Effect of Hypertonic Solutions on Allergic Rhinitis Patients
The purpose of this study is to assess the effectivity of using hypertonic nasal solutions alone on the symptom scores and nasal eosinophil levels of allergic rhinitis patients, retrospectively.
- Trial name
- hypertonic (NCT02233426)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Namik Kemal University
Cystic Fibrosis
Study of Long-term Treatment With Hypertonic Saline in Patients With Cystic Fibrosis
A phase IV clinical trial, multicentric (3 Hospitals in Madrid) controlled, prospective, open and randomized of long-term treatment with hypertonic saline in cystic fibrosis patients.
- Trial name
- NCT01377792
- Testing
- Hypertonic saline
- Where
- Spain
- Volunteers
- 71 people
- Sponsor
- Adelaida Lamas Ferreiro
COVID-19
Hypertonic Saline for COVID-19 Symptoms
Rationale: Coronavirus disease 2019 (COVID-19) is spreading rapidly in the world with no proven effective therapy to date. Some patients with COVID-19 develop sever respiratory disease requiring ICU care.
- Trial name
- NCT04465604
- Testing
- Wearing surgical face mask sprayed with hypertonic saline
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Chronic Rhinosinusitis (Diagnosis)
Hypertonic Versus Isotonic Saline Irrigations for Chronic Rhinosinusitis
The study aims to determine the safety and efficacy of buffered hypertonic (1.8%) saline nasal rinses as compared to isotonic saline nasal rinses in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT04242368
- Testing
- Isotonic saline, Hypertonic Nasal Wash, Fluticasone Propionate
- Where
- United States
- Sponsor
- Stanford University
Fetal Bradycardia, Hypertonic Uterine
Plasmatic Catecholamines: Randomized Controlled Trial Comparing Epidural Versus Combined Spinal-epidural
Combined spinal-epidural (CSE) for labor analgesia has been associated with fetal bradycardia and uterine hypertonia, possibly due to asymmetric decrease in catecholamine levels, when compared with epidural analgesia (EP).
- Conditions
- Fetal Bradycardia, Hypertonic Uterine, Catecholamines
- Trial name
- NCT02666794
- Testing
- Epidural bupivacaine with vasoconstrictor 0.125%, Epidural sufentanil, Placement of the epidural catheter
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Cystic Fibrosis
Cell Content of Sputum Induced by Hypertonic Saline in Adolescents With Cystic Fibrosis
Cystic fibrosis requires regular monitoring of bacterial colonization of sputum. The collection is done during scheduled consultations or urgently during exacerbations during the respiratory physiotherapy session, which is…
- Trial name
- OCSI-CF (NCT06909903)
- Testing
- Autogenous drainage of sputum caused by hypertonic saline in adolescents with cystic fibrosis.
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cystic Fibrosis
The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic Fibrosis
This study is examining the effect of hypertonic saline compared to placebo on the Lung Clearance Index in Cystic Fibrosis patients.
- Trial name
- NCT00635141
- Testing
- hypertonic saline (7 %) and isotonic saline (0.9%)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Cystic Fibrosis
Infant Study of Inhaled Saline in Cystic Fibrosis
The purpose of this study is to assess whether 7% hypertonic saline (HS) is an effective and safe therapy in infants and young children with CF.
- Trial name
- ISIS (NCT00709280)
- Testing
- 7% Hypertonic Saline (HS), 0.9% Isotonic Saline (IS)
- Where
- 30 sites in United States, Canada
- Volunteers
- 321 people
- Sponsor
- CF Therapeutics Development Network Coordinating Center
Epilepsy
Tonicity Monitor For Epilepsy and Hypertonic Disorders
Epilepsy is an episodic disorder which can result in recurrent seizures often associated with hypertonia (muscle stiffening) and myoclonia (involuntary muscle jerking).
- Trial name
- NCT02110589
- Testing
- Epidetect
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Vikel Ltd
Atelectasis
Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis in Non-Cystic Fibrosis Patients
Despite the lack of trials proving the efficacy of DNase in non cystic fibrosis patients, it is currently heavily used in this population.
- Trial name
- NCT00671723
- Testing
- Normal saline:, Hypertonic Saline, Dornase alpha
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Oklahoma
TMJ Disc Disorder
Therapeutic Effect of Proliferative Therapy (Prolotherapy) on Pain Using Injectable Hypertonic Dextrose 25% Versus Injectable Dextrose 10% in Retrodiscal Tissues in Patients With Anterior Disc Displacement With Reduction: A Randomized Clinical Trial .
prolotherapy is an injection-based treatment method used to alleviate pain, particularly musculoskeletal pain associated with chronic ligament and tendon injuries.
- Trial name
- NCT06859034
- Testing
- injection of dextrose 10% in retrodiscal tissues, injection of dextrose 25% in retrodiscal tissues
- Volunteers
- 24 people
- Sponsor
- Cairo University
Temporomandibular Joint Disorders
Treatment of Temporomandibular Dysfunction With Hypertonic Dextrose Injection
Dysfunction of the jaw, associated with pain in the jaw or about the jaw in the face can be quite long lasting and debilitating.
- Trial name
- NCT01706172
- Testing
- Injection of 20% dextrose/ 0.2% lidocaine, Injection of 1 ml of 0.8 Sterile water /0.2% lidocaine
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Chisel Peak Medical Clinic
Asthma
Hypertonic Saline as Add on Therapy in Preschool Children With Acute Wheezing Attack.
To investigate the efficacy of adding Inhaled Hypertonic Saline treatment (HS) for 1-6 year old children with "asthmatic" attack presenting to Emergency Department (ED).
- Trial name
- NCT01073527
- Testing
- hypertonic saline-salbutamol combination, Normal saline-salbutamol combination
- Where
- Israel
- Volunteers
- 41 people
- Sponsor
- Wolfson Medical Center
Acute Kidney Injury, Osmolality Disturbance
Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Conditions
- Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass
- Trial name
- NCT05914896
- Testing
- HighOsmo
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Respiratory Distress Syndrome, Adult, Head Injuries, Closed
Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury
The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD)…
- Conditions
- Respiratory Distress Syndrome, Adult, Head Injuries, Closed, Shock, Shock, Traumatic
- Trial name
- NCT00113685
- Testing
- Hypertonic Saline-Dextran Solution, Lactated Ringer's Solution
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- University of Washington
Traumatic Brain Injury, Subdural Hematoma
Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury
Cerebral edema is seen heterogenous group of neurological disease states that mainly fall under the categories of metabolic, infectious, neoplasia, cerebrovascular, and traumatic brain injury disease states.
- Conditions
- Traumatic Brain Injury, Subdural Hematoma, Cerebral Contusion, Head Injury
- Trial name
- NCT01605357
- Testing
- Induced, sustained hypernatremia using hypertonic saline, Standard of care (hypertonic saline and mannitol; serum sodium)
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury
Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values
The purpose of this study is to determine whether hypertonic saline is as much effective as mannitol to treat intracranial hypertension after traumatic brain injury and has at least the same effects on PtiO2 and cerebral…
- Trial name
- NCT01028339
- Testing
- Hypertonic saline, Mannitol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Subarachnoid Hemorrhage
HyperHAES Versus Placebo - Effect on Intracranial Pressure in SAH Patients
The purpose of this study is to determine whether 7.2% NaCl in 6% hydroxyethyl starch will lower intracranial pressure (ICP) in SAH-patients with normal or moderately elevated ICP in a placebo controlled study, and to describe…
- Trial name
- NCT00199706
- Testing
- 7.2% NaCl in 6% hydroxyethyl starch solution
- Volunteers
- 20 people
- Sponsor
- Oslo University Hospital