Clinical trials: ICSI
Reproductive Techniques, Assisted
Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles (LUTEAL Trial)
Exploratory, prospective, randomized, comparative, open trial with control group treated to assess the efficacy of follicular phase ovarian stimulation compared to lutheal phase ovarian stimulation in women with Bologna criteria…
- Trial name
- LUTEAL (NCT02625532)
- Testing
- Follicular phase, Luteal phase
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Exposure to Toxins from Smoking, Female Infertility
Presence of Toxins from Smoking in the Follicular Fluid of Women Undergoing Intracytoplasmic Sperm Injection Treatment
Smoking is associated with many adverse health effects like circulatory disorders, pulmonary diseases or heart diseases. It was also shown that smoking correlates with a significantly higher risk for miscarriage, preterm birth or…
- Trial name
- NCT03414567
- Where
- Germany
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Fetal Cardiac Disorder
Fetal Cardiac Remodeling in Singleton Pregnancies Conceived by Assisted Reproductive Technology (Biopsied and Non-Biopsied ICSI) Versus Those Normally Conceived
The study aims to assess the presence of fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived…
- Trial name
- NCT05172336
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Wael Elbanna Clinic
Infertility, Reproductive Issues
Impact of a Predetermined Day 5 ET vs. a Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment
The aim of this prospective multicenter study is to investigate the influence of a predetermined embryo transfer on day 6 compared to a predetermined embryo transfer on day 5.
- Trial name
- NCT06447077
- Where
- Germany
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Stimulation in the Ovary, IVF Outcome
Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
There are several approaches to the timing of antagonist administration in IVF/ICSI cycles. The primary goal is indeed to prevent premature ovulation, which could jeopardize the success of the cycle There is an emerging concept…
- Trial name
- NCT06879002
- Testing
- Ovarian stimulation with menstruation or after ovulation
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Recurrent Implantation Failure
Platelet Rich Plasma and Recurrent Implantation Failure
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure.
- Trial name
- NCT03996837
- Testing
- Intra uterine infusion of platelet rich plasma
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royan Institute
ICS
Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction.
- Trial name
- NCT07318974
- Testing
- Melatonin capsule
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Benha University
Infertility
Automation of Gamete Preparation, Intracytoplasmic Sperm Injection (ICSI), Embryo Culture, and Vitrification
Patients suffering from infertility may seek assisted conception treatment. In a full treatment cycle, the sperm and eggs (gametes) from the intended parents will be looked after by skilled laboratory staff (embryologists) who…
- Trial name
- NCT06074835
- Testing
- Gamete preparation, ICSI, embryo culture and vitrification robot assistant, Routine Manual ICSI Workflow
- Where
- Mexico
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Infertility
Study of Free DNA Content of Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment
Study of Cell Free DNA Content of Human Embryo Culture Medium as a Non-Invasive Tool for Embryo Assessment in intra cytoplasmic sperm injection Treatment Cycles.
- Trial name
- NCT02480491
- Testing
- measuring cell freeDNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sadat City University
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Ovarian Hyperstimulation Syndrome
Double GnRH Antagonist Daily Dose in Hyperresponding IVF/ICSI Cycles May Prevent the OHSS
The possibility to prevent the early ovarian hyperstimulation syndrome (OHSS) by doubling the daily dose of GnRH-antagonist in women stimulated with the antagonist protocol who are at risk for OHSS was evaluated.
- Trial name
- NCT01477970
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Iakentro Fertility Centre
Endometrial Receptivity
Comparison of Blood Flow in the Arteriae Uterinae in Ovarian Stimulation Cycles
This study will measure the blood flow in the aa. uterinae in women, undergoing firstly ovarian stimulation for In-Vitro Fertilization (IVF) / Intracytoplasmic sperm injection (ICSI), in Hormonal Replacement cycles (HRT) and…
- Trial name
- NCT03887728
- Where
- United Arab Emirates
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
Failure of Implantation After Recurrent Embryo Transfers
We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment.
- Trial name
- NCT00351481
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Polycystic Ovary Syndrome, Infertility
Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient
this study is designed to compare the Progesterone primed ovarian stimulation protocol versus the antagonist protocol as a method to stimulate PCO patients in ICSI cycles to decrease cost and decrease OHSS.
- Conditions
- Polycystic Ovary Syndrome, Infertility, IVF
- Trial name
- NCT05847660
- Testing
- Progesterone antagonist, conventional antagonist protocol
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Infertility, Infertility, Female
A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation
This study will determine the rise of progesterone levels after human chorionic gonadotrophin (hCG) trigger in stimulated cycles IVF/ICSI
- Conditions
- Infertility, Infertility, Female, IVF, hCG
- Trial name
- NCT04417569
- Testing
- hCG, Ultrasound, Blood test
- Where
- United Arab Emirates
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Luteal Phase
Vaginal Versus Combined Use of Progesterone in Fresh IVF/ICSI Cycles
Hypothesis: the combined use of progesterone administration for luteal phase support is superior to the single route of progesterone administration in terms of pregnancy outcome parameters in women undergoing fresh IVF/ICSI…
- Trial name
- NCT05089383
- Testing
- Utrogestan
- Where
- Greece
- Volunteers
- 698 people, healthy volunteers welcome
- Sponsor
- University of Athens
Polycystic Ovary Syndrome
Metformin in Assisted Reproduction-MET-AR-study
Aim of study: To investigate whether four months of metformin treatment before IVF (in-vitro-fertilisation) or ICSI (intra-cytoplasmic-sperm-injection) might increase clinical pregnancy rate in normal-weight (body mass index…
- Trial name
- NCT00159575
- Where
- 2 sites in Norway
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Endometriosis
Use of Antioxidant in Endometriotic Women to Improve Intracytoplasmic Sperm Injection (ICSI)
ROS plays an essential role in the pathogenesis of many reproductive processes. High follicular fluid ROS levels are associated with negative IVF outcomes.
- Trial name
- ROS (NCT02058212)
- Testing
- ascorbate 1000mg, vitamin E 400, zinc and selenium
- Where
- 3 sites in Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Preterm Birth, Gestational Diabetes Mellitus (GDM)
Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology Compared to Other Fertility Treatments and Naturally Conceived Women: It is a Retrospective Cohort Study Conducted Over a 5-year Period at a Fertility Center in a Lebanese Hospital
Background: The number of couples experiencing difficulties conceiving and seeking treatment for infertility has increased dramatically over time.
- Conditions
- Preterm Birth, Gestational Diabetes Mellitus (GDM), Gestational Hypertension
- Trial name
- non (NCT06836843)
- Testing
- Since this is an observational study rather than an interventional study, the exposure type refers to all potential factors influencing pregnancy both before and during pregnancy
- Where
- Lebanon
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel