Clinical trials: INDIVIDUALIZED THERAPY
Feasibility, Effectiveness
a Prospective Registration Study for Patients With Advanced Refractory Solid Tumors
This is a prospective registration study for patients with advanced refractory solid tumors. Patients who meet the eligibility criteria will be included to participate in the study, and baseline information to be collected after…
- Conditions
- Feasibility, Effectiveness, Safety, Targeted Molecular Therapy
- Trial name
- NCT05177666
- Testing
- Targeted therapy
- Volunteers
- 120 people
- Sponsor
- The University of Hong Kong-Shenzhen Hospital
Invasive Fungal Infection
An Individualized Administration Research of Voriconazole Based on CYP2C19 Gene Polymorphism and TDM
This was a prospective clinical study that all voriconazole-treated adult Chinese patients with invasive pulmonary infection admitted to Zhengzhou Central Hospital affiliated to Zhengzhou University from March 2018 to April 2020.
- Trial name
- NCT04004078
- Testing
- other antifungal agents,breathing machine
- Where
- China
- Volunteers
- 314 people
- Sponsor
- People's Hospital of Zhengzhou University
Esophageal Squamous Cell Carcinoma
Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)
The goal of this observational study or is to explore the correlation between dynamic changes in postoperative circulating tumor DNA (ctDNA) and recurrence risk using a novel, tumor-informed ctDNA detection technique, thus laying…
- Trial name
- NCT06561178
- Testing
- molecular residual disease detection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-Sen University Cancer Center
GLP - 1, Obesity & Overweight
Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1
Obesity remains a critical public health challenge and is associated with increased rates of morbidity, mortality, and chronic disease worldwide.
- Conditions
- GLP - 1, Obesity & Overweight, Muscle Loss, Exercise Intervention
- Trial name
- NCT07554417
- Testing
- Semaglutide, Dietary Counseling, Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- William Marsh Rice University
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neuroendocrine Tumors
Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors
This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE.
- Trial name
- NCT02743741
- Testing
- Lutetium-177 Octreotate
- Where
- 4 sites in Canada
- Volunteers
- 195 people
- Sponsor
- University Health Network, Toronto
Uncontrolled Hypertension
An Interventional Multidisciplinary Approach to Individualize Blood Pressure Treatment
The aim of the study is to investigate and explore the most important aspects of drug-adherence in the treatment of hypertension in order to improve treatment and blood pressure control, implying that new knowledge will reduce…
- Trial name
- IDA (NCT03209154)
- Testing
- Therapeutic drug monitoring, Home blood pressure monitoring
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- Oslo University Hospital
Bronchiectasis, Quality of Life
Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials
Treatment based on syndrome differentiation is the essence of traditional Chinese Medicine(TCM) and forms the individualized treatment.
- Conditions
- Bronchiectasis, Quality of Life, Traditional Chinese Medicine, Sputum
- Trial name
- NCT03147443
- Testing
- Individualized Decoction, Tested drug minus heat-clearing herbs
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Stage IV Colorectal Cancer
Individualized Nutritional Counselling During Chemotherapy for Colorectal Cancer (COLONUT)
The purpose is to study the effect of individualized nutritional counselling compared to usual nutritional care on cross-sectional muscle area in patients with stage IV colorectal cancer during first line chemotherapy.
- Trial name
- COLONUT (NCT01998152)
- Testing
- Nutritional counseling
- Where
- 5 sites in Netherlands
- Volunteers
- 107 people
- Sponsor
- Amsterdam UMC, location VUmc
Alcoholism
Acamprosate: Genes Associated With Response
In 2004, acamprosate was approved in the U.S. for abstinence maintenance, by decreasing craving, in alcoholic patients who have undergone detoxification.
- Trial name
- ACAM (NCT00662571)
- Testing
- acamprosate
- Where
- United States
- Volunteers
- 485 people
- Sponsor
- Mayo Clinic
Esophageal Cancer
Real-world Study on Comprehensive Treatment of Esophageal Cancer Based on Precision Radiotherapy
Radiotherapy is one of the main treatments for locally advanced esophageal carcinoma (EC). The accuracy of the existing imaging methods in diagnosing and predicting therapeutic efficacy is disappointing, which increases the…
- Trial name
- NCT05543057
- Testing
- 3DCRT
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zefen Xiao
Stage III Non-small Cell Lung Cancer, Individualized Radiation Dose Escalation
Individualized Dose Prescription in Advanced Stage Lung Cancer Patients Using Modern (Chemo)Radiotherapy
The aim of this present study is to test the feasibility and toxicity of individualized hypofractionated radiotherapy, and to report outcome data.
- Trial name
- IDEAL-VMAT (NCT01577212)
- Testing
- Individualized dose escalation
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Cirrhosis, Liver
The Establishment of Multiple Point Prediction Model About Tacrolimus Metabolic Differences Based on Genetic Network After Liver Transplantation and the Application of Multicenter
Combined with the clinical data of FK506 and the database of GO and Kyoto Encyclopedia of Genes and Genomes（KEGG）, the investigators aim to carry out the bioinformatic analysis and build a muti-locus genetic model, then…
- Trial name
- NCT02752529
- Testing
- Tacrolimus（FK506）
- Where
- China
- Volunteers
- 415 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Biliary Malignant Tumors
Evaluation of the Safety, Tolerability and Efficacy of iNeo-Vac-R01, an Individualized mRNA Therapeutic Technology Based on Tumor Neoantigens, for Adjuvant Treatment in Patients With Biliary Malignant Tumors After Radical Resection
The primary objective of this study is to evaluate the safety of iNeo-Vac-R01, an individualized mRNA therapeutic technology based on tumor neoantigens, for the adjuvant treatment of patients with biliary malignant tumors after…
- Trial name
- NCT07368803
- Testing
- iNeo-Vac-R01
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yifan Wang
PreDiabetes, Cardiovascular Diseases
Individualized Nutrition Therapy for Preventing or Delaying Onset of Type-2 Diabetes
The overall aim of this feasibility study is to conduct a randomized, controlled intervention providing adults with prediabetes either an individualized nutrition therapy (INT) intervention that contains individualized dietary…
- Trial name
- NCT05161897
- Testing
- Individualized Nutrition Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Mason University
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Individualized AML Treatment
Every patient responds differently to their cancer treatment, and some treatments work better for some patients more than others.
- Trial name
- NCT07613385
- Testing
- Observational
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Coronary Artery Disease, Percutaneous Coronary Intervention
Patient Centered Machine Learning Model for Bleeding and Ischemic Risk
Dual antiplatelet therapy (DAPT) is indicated in all patients undergoing coronary stent implantation to prevent ischemic recurrencies despite an increased risk of bleeding.
- Trial name
- xDAPT (NCT06089304)
- Testing
- Percutaneous coronary intervention
- Where
- United States
- Volunteers
- 19,000 people
- Sponsor
- Abbott Medical Devices
Wheelchair Users, Pressure Ulcer Prevention
The Effect of Pressure Injury Training on Knowledge Levels and Wound Prevention in Wheelchair Users
This research is a randomised controlled study conducted to evaluate the effects of training given to wheelchair users to prevent pressure injury on their level of knowledge, prevention of pressure injury and wound healing.
- Conditions
- Wheelchair Users, Pressure Ulcer Prevention, Pressure Ulcer (PU)
- Trial name
- NCT07438899
- Testing
- education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Relapsed Hematologic Malignancy
Extended Analysis for Leukemia/Lymphoma Treatment
Patients with relapsed/ refractory acute leukemia and relapsed/ refractory aggressive lymphoma harboring an activating genetic alteration (gene mutation, gene fusion) or drug-able biomarker / activated signal transduction pathway…
- Trial name
- EXALT (NCT03096821)
- Testing
- ngFDS selected treatment
- Where
- Austria
- Volunteers
- 143 people
- Sponsor
- Medical University of Vienna
Solid Tumor
Individualized Tumor Specific TCR- T Cells in the Treatment of Advanced Solid Tumors
The primary purpose of this study is to evaluate the safety of the tumor-specific TCR-T cells in the treatment of advanced Solid Tumor .
- Trial name
- NCT03891706
- Testing
- tumor-specific TCR-T cells, Interleukin-2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou FineImmune Biotechnology Co., LTD.