Clinical trials: Impaired Glucose Tolerance (Prediabetes)
Diabete Type 2
Effect of a Healthy Food Voucher on Blood Glucose Control in People With Type 2 Diabetes or Prediabetes
This randomized controlled trial (RCT) will determine if access to a voucher for healthy foods reduces blood sugar levels among people living on a low income who have type 2 diabetes or elevated blood sugar.
- Trial name
- VOUCH4DIABETES (NCT05776420)
- Testing
- Food voucher
- Where
- Canada
- Volunteers
- 390 people
- Sponsor
- Unity Health Toronto
PreDiabetes, Type 2 Diabetes Mellitus
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
The goal of this clinical trial is to compare the degree of effort during a resistance exercise session on blood glucose levels in individuals with prediabetes or type 2 diabetes mellitus.
- Trial name
- NCT06208189
- Testing
- High-effort session, Low-effort session, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
PreDiabetes, Diabetes Mellitus, Type 2
Oral Endocannabinoids in People With Prediabetes and Diabetes
This study evaluates the relationship of endocannabinoids in saliva with inflammation and oral dysbacteriosis present in people with periodontal disease and prediabetes/type 2 diabetes
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Obesity, Oral Dysbiosis
- Trial name
- SMILE (NCT06040164)
- Testing
- Observational study
- Volunteers
- 60 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Prediabetes
Effects of a Mediterranean Diet With Sequential Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes or Prediabetes Remission
The goal of this clinical trial is to learn how a Mediterranean-style diet, with and without added exercise, affects blood sugar control in women with prediabetes.
- Trial name
- NCT07326891
- Testing
- Mediterranean Diet, Supervised Sequential Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Begüm Yücesoy Güneysu
PreDiabetes
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
A large body of research has demonstrated that intensive lifestyle interventions and metformin are effective treatments to prevent or delay diabetes among high-risk adults, yet neither treatment is routinely used in practice.
- Trial name
- BEGIN (NCT04869917)
- Testing
- Decision Aid intervention, Text Messaging intervention, Usual Care
- Where
- United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Glucose Intolerance
Effect of Feeding Frequency on Glucose and Insulin Metabolism and Substrate Partitioning in Impaired Glucose Tolerant (IGT) Men
The purpose of this study is to determine the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning in impaired glucose tolerant (IGT) men.
- Trial name
- NCT01456754
- Testing
- low feeding frequency (3x), High feeding frequency (14x)
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Maastricht University Medical Center
PreDiabetes, Diabetes Mellitus, Type 2
Acceptance and Commitment Therapy Principles for Diabetes Prevention
The investigators will evaluate whether a brief intervention (i.e. a workbook and video presenting educational information and activities materials for diabetes prevention) that incorporates principles drawn from focused…
- Conditions
- PreDiabetes, Diabetes Mellitus, Type 2, Diabetes, Diabetes type2
- Trial name
- NCT05260983
- Testing
- Diabetes Prevention Education and Acceptance and Commitment Therapy, Diabetes Prevention Education Only
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- University of Oregon
PreDiabetes, Diabetes Mellitus
Dried Fruit and Postprandial Glycemia Trial
Dried fruits show promising potential for the management of blood glucose. Previous trials have reported beneficial effects of raisins on post-prandial glucose and insulin responses in healthy individuals when compared with white…
- Conditions
- PreDiabetes, Diabetes Mellitus, Dysglycemia
- Trial name
- NCT02960373
- Testing
- White Bread (Control), Dried Fruit - Glycemic Index, Catalytic Fructose Dose Effect
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Impaired Glucose Tolerance, Prediabetes
CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance
The incidence of type 2 diabetes (T2D) in children is increasing, paralleling the rising incidence of obesity. Preventing children and adolescents from developing T2D is critical.
- Trial name
- NCT05387551
- Testing
- CGM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nemours Children's Clinic
Prediabetes
Role of Slowly Digesible Starch on Diabetes Risk Factors
The purpose of this study is to determine the effect of a slowly digesting starch on gut bacteria, sugar and fat metabolism, hunger hormones, and body fat in people with pre-diabetes.
- Trial name
- STARCH (NCT01708694)
- Testing
- Amylose, Amylopectin
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Pennington Biomedical Research Center
PreDiabetes, Impaired Fasting Glucose (IFG)
Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.
This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000…
- Conditions
- PreDiabetes, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT)
- Trial name
- NCT03398356
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Diabetes Mellitus, Type 2, Glucose Intolerance
Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2
The purpose of this study is to evaluate if treatment with vitamin D increase beta cell function and insulin sensitivity in subjects with pre-diabetes or newly diagnosed diabetes mellitus type 2.
- Conditions
- Diabetes Mellitus, Type 2, Glucose Intolerance, Vitamin D Deficiency
- Trial name
- EVIDENS (NCT01497132)
- Testing
- Vitamin D3
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Karolinska Institutet
Prediabetes
Effect of Inulin-type Fructose Extracted From Jerusalem Artichoke on Improving Prediabetic State of Type 2 Diabetes
The trial was a multicenter, randomized, double-blind, placebo-controlled, parallel-controlled, exploratory clinical study.Through the intervention of soluble dietary fiber in the pre-type 2 diabetic population, the change of…
- Trial name
- NCT03794232
- Testing
- NIUCHANG
- Volunteers
- 246 people
- Sponsor
- Inuling (Bei Jing) Science and Technology Co. Ltd
PreDiabetes
Efficacy of Physical Exercise on Glucose Control in People With Prediabetes
To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes.
- Trial name
- GLYCEX (NCT05612698)
- Testing
- Aerobic training, Aerobic training plus resistance training, High intensive interval training
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Diabete Mellitus, Prediabetes
Amelioration of Lipid Profile Through Date Cider-vinegar Along With 5:2 Intermittent Fasting
A common metabolic abnormality in hyperglycemic individuals, dyslipidemia is strongly linked to an increased risk of cardiovascular illness.
- Conditions
- Diabete Mellitus, Prediabetes, Hyperlipidemia
- Trial name
- NCT07710898
- Testing
- Control Group (T 0 ), Experimental Group (T 1 ), Experimental Group (T 2 )
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- University of Lahore
Hypertriglyceridemia, Glucose Intolerance
Impact of Plasma Lipids on β Cell Function and Insulin Sensitivity
The investigators aim to evaluate whether and to what extent glucose tolerance, beta cell function, insulin clearance, and glucose metabolic fluxes change in response to an acute increase in plasma triglycerides during lipid…
- Trial name
- NCT05181514
- Testing
- 20% Intralipid, Normal Saline
- Where
- Italy
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Cystic Fibrosis Homozygous for Phe 508 Del CFTR, Glucose Intolerance or Newly Diagnosis Diabetes
Observational Study of Glucose Tolerance Abnormalities in Patient With Cystic Fibrosis Homozygous for Phe 508 Del CFTR Treated by Lumacaftor-Ivacaftor
Cystic Fibrosis related diabetes (CFRD), a major factor of morbid-mortality in CF, is characterized by a preclinical phase of glucose intolerance particularly long reaching up to 10 years.
- Trial name
- GLUCORRECTOR (NCT03512119)
- Testing
- Lumacaftor-Ivacaftor treatment
- Where
- 13 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Strasbourg, France
PreDiabetes, Diabetes Mellitus, Type 2
Chronotype, Chrononutrition and Glucose Tolerance Among Prediabetic Individuals
Chronotype and chrononutrition, both are emerging research fields in nutritional epidemiology. However, its association with glycemic control in the global population is less clear.
- Trial name
- NCT05163964
- Testing
- Lifestyle Intervention
- Where
- 11 sites in Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
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