Clinical trials: Implementation, open to volunteers
Adolescent HIV Infection
Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth (iCARE) Plus Effectiveness/Implementation Hybrid Study
Two combination interventions (HIV Case Finding Intervention and HIV Treatment Intervention), each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials…
- Trial name
- iCARE Plus (NCT06880224)
- Testing
- Testing Peer navigation, PrEP Intervention, Treatment Peer Navigation
- Where
- 6 sites in Nigeria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Child Sexual Abuse
Parent-focused Primary Prevention of Child Sexual Abuse: An Effectiveness-implementation Hybrid Trial
The goal of this clinical trial is to test the effectiveness of a parent-focused child sexual abuse prevention program (Smart Parents) delivered to parents enrolled in a parent education program (Parents as Teachers; PAT).
- Trial name
- NCT05976867
- Testing
- Parents as Teachers (PAT) as usual, Parents as Teachers (PAT) + Smart Parents
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- New York University
TBI (Traumatic Brain Injury), Implementation Research
Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test
The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential…
- Trial name
- EDI (NCT07373509)
- Testing
- i-STAT Alinity TBI test
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Shawn Eagle
Stress, Postpartum Depressive Disorder
Powerly - Science-based Digital Intervention Preventing Postpartum Depression and Anxiety
The goal of this clinical trial is to determine if the Powerly app can help prevent postpartum depression and anxiety in healthy pregnant women.
- Conditions
- Stress, Postpartum Depressive Disorder, Postpartum Anxiety
- Trial name
- POWERLY app (NCT06610552)
- Testing
- Powerly
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Marta Marciniak
Opioid Use Disorder
Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder
The goal of this clinical trial is to learn if a hospital-based approach can help people with opioid use disorder (OUD) connect to a methadone clinic after leaving the hospital.
- Trial name
- HOTPIN-IF (NCT07568847)
- Testing
- HOTPIN-IF
- Volunteers
- 1,440 people
- Sponsor
- University of Colorado, Denver
Perioperative Patient Safety
ClassIntra® for Better Outcomes in Surgery - CIBOSurg
Intra- and postoperative adverse events (iAEs and pAEs) occur in up to one third of all patients undergoing surgery. They are devastating to patients and costly to health care systems.
- Trial name
- CIBOSurg (NCT05818332)
- Testing
- Observational study
- Where
- 10 sites in Netherlands, Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University Hospital, Basel, Switzerland
Adult Non-trauma Cardiac Arrest Resuscitation, Effectiveness of In-situ Simulation (ISS) Training
Effectiveness of In-Situ Simulation Training in Adult Non-Trauma Resuscitation: A Comparison of ISS and OSS Team Performance Using the A-C-L-S Model
This study employed a two-group non-randomized pre-post design to evaluate the effectiveness of interprofessional ISS training over one year at the National Taiwan University Hospital Yunlin Branch.
- Conditions
- Adult Non-trauma Cardiac Arrest Resuscitation, Effectiveness of In-situ Simulation (ISS) Training, Effectiveness of Off-site Simulation (OSS) Training, Improvement of Teamwork in Emergency Care Settings
- Trial name
- NCT07358793
- Testing
- In-situ Simulation (ISS) Training, Off-site Simulation (OSS) Training
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acceptability, Feasibility Studies
Digital Support Strategies for Caregiver Home Practice
This project is a pilot trial of the Engaging Families home practice smartphone application (or "app") as an add on to a family-based prevention program.
- Trial name
- NCT06907966
- Testing
- Engaging Families home practice app, Scheduling app
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Cancer, Head and Neck Cancer
EXCEL: Exercise for Cancer to Enhance Living Well
Project EXCEL will provide community or online exercise programs to rural and remote and under-served cancer survivors, as well as encourage participants to become life-long exercisers.
- Conditions
- Cancer, Head and Neck Cancer, Colon Cancer, Breast Cancer
- Trial name
- EXCEL (NCT04478851)
- Testing
- Group Exercise Classes
- Where
- 3 sites in Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Suicidal Ideation and Behavior
Adapting Youth Nominated Support Team (YST) to Prevent Suicide
The goal of this study is to conduct a pilot test of a mental health support program called the Youth-Nominated Support Team - Probation (YST-P) for young people ages 12-17 on probation, experiencing suicidal ideation and…
- Trial name
- NCT07559955
- Testing
- Youth-Nominated Support Team for Probation
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Columbia University
Acute Coronary Syndrome (ACS), Myocardial Infarction
TeleheartCR vs. Clinic-Based Cardiac Rehabilitation After Acute Coronary Syndrome
Cardiac rehabilitation (CR) is an effective evidence-based intervention that improves outcomes in patients with acute coronary syndrome (ACS), but many eligible patients do not complete the program.
- Trial name
- NCT07541014
- Testing
- Telehealth-enhanced Hybrid CR, Traditional Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Columbia University
Smoking Cessation
Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)
The purpose of this study is to refine and pilot an intervention using the Nicotine Metabolite Ratio (NMR) to inform the selection of pharmacologic treatment to increase smoking abstinence among Alaska Native and American Indian…
- Trial name
- QUIT (NCT06556238)
- Testing
- Nicotine Metabolite Ratio
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Southcentral Foundation
Epilepsies
Artificial Intelligence for Brain MRI Analysis in Epilepsy
This study will test computer programs that help doctors read brain MRI scans. The programs use artificial intelligence (AI). The study includes people with epilepsy, a condition that causes repeated seizures.
- Trial name
- RMNEPI22 (NCT07881185)
- Where
- 23 sites in United States, Australia and 11 more
- Volunteers
- 2,000 people
- Sponsor
- Istituto Giannina Gaslini
Suicide
Army-SPRING Army-Suicide Prevention Research
Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources…
- Trial name
- NCT06547008
- Testing
- Army-SPRING, Risk Reduction Group (Control)
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Suicide
Scaling up e-Connect in Juvenile Probation Settings
We propose to conduct research on strategies that support the successful scale-up of an evidence-based, suicidal risk and behavior identification and cross-system linkage programs for justice-involved youth (e-Connect), and to…
- Trial name
- NCT05541926
- Testing
- e-Connect
- Where
- United States
- Volunteers
- 3,629 people
- Sponsor
- New York State Psychiatric Institute
Hip Fractures, Femoral Neck Fractures
Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)
The objective of this study is to assess the implementation process for and the effectiveness of a quality improvement (QI) strategy to increase shared decision-making around anesthesia options for hip fracture surgery at 6 US…
- Conditions
- Hip Fractures, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
- Trial name
- NCT06438640
- Testing
- My Anesthesia Choice-HF Model
- Where
- 6 sites in United States
- Volunteers
- 1,881 people
- Sponsor
- University of Pennsylvania
Perinatal Depression, Perinatal Anxiety
Feasibility and Implementation of Early Referral in Perinatal Mental Health
This study is part of the e-Perinatal project and is embedded within the main cluster randomized trial. The primary aim is to evaluate the feasibility, acceptability, and preliminary effectiveness of an early diagnosis detection…
- Trial name
- e-Perinatal-Re (NCT07609550)
- Testing
- The e-Perinatal intervention is a personalized mobile health (mHealth) program, Standard routine maternal care
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Seville
Testicular Cancer, Testicular Germ Cell Tumor
Follow-up After Surgery for Testicular Cancer
The currently developed implementation study aims to evaluate if a patient-led home-based follow-up approach is successful, improves quality of life, reduces anxiety and lessens fear of cancer recurrence during the years after…
- Conditions
- Testicular Cancer, Testicular Germ Cell Tumor, Quality of Life
- Trial name
- FUTURE-testis (NCT05670938)
- Where
- Netherlands
- Volunteers
- 145 people
- Sponsor
- Erasmus Medical Center
Rectal Cancer
Response-adapted Total Neoadjuvant Therapy Guided by Induction Chemotherapy in Early- and Intermediate-risk Low Rectal Cancer for Implementation of a Watch-and-wait Strategy
This study investigates the feasibility of an organ-preserving "watch-and-wait" strategy in patients with mid-to-low rectal cancer who achieve a good response after total neoadjuvant therapy (TNT).
- Trial name
- NCT07260526
- Where
- China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Cancer, Survivorship
Study of a Support Program for Quality of Life in Chinese Cancer Patients and Survivors
The purpose of this study is to evaluate different combinations of cancer education sessions, counseling sessions, and peer support meetings developed for Chinese cancer patients and survivors.
- Trial name
- NCT07454330
- Testing
- Cancer Education, Meaning-Centered Counseling, Peer Support
- Where
- 7 sites in United States
- Volunteers
- 64 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
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