Clinical trials: Infant Neurodevelopment
Congenital Heart Disease, Child Development
NeuroCardio Baby Research Outpatient Clinic: Study on the Neurodevelopment of Infants With Congenital Heart Disease in Brazil
The objective of this randomized clinical trial is to test the effectiveness of a low-cost hybrid remotely monitored parent-mediated and clinic-based multidisciplinary early intervention (EI) for low-income infants with CHD in…
- Conditions
- Congenital Heart Disease, Child Development, Early Intervention
- Trial name
- NCT05907109
- Testing
- Remotely monitored parent-mediated hybrid home and clinic based multidisciplinary Early Intervention protocols.
- Where
- 2 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Premature Birth
Early Intervention in Preterm Infants: Short and Long Term Developmental Outcome After a Parental Training Program
Preterm infants, during their stay in the Neonatal Intensive Care Unit (NICU), face a period of stressful environment, which may negatively impact early brain development and subsequent neurobehavioral outcomes.
- Trial name
- NCT02983513
- Testing
- Early Intervention
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Preterm, Neurodevelopmental Disorder
Biomarkers, Neurodevelopment and Preterm Infants
Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders.
- Conditions
- Preterm, Neurodevelopmental Disorder, Epigenetic Changes
- Trial name
- NCT02557191
- Testing
- Observational study
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Developmental Delay, Iron Deficiency
Early Versus Delayed Cord Clamping at Term: Neurodevelopmental Outcomes in Swedish Infants at 4 Years of Age
Delayed clamping of the umbilical cord might prevent or slow the onset of iron deficiency by increasing the infant's iron endowment at birth.
- Trial name
- NCT01581489
- Testing
- Time to clamping of the umbilical cord after delivery
- Where
- Sweden
- Volunteers
- 263 people
- Sponsor
- Uppsala University
Vitamin B 12 Deficiency
A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment
Supplementation with Iron and folate have been part of a worldwide strategy targeting anaemia and neural tube defects for many years. However, vitamin B12 deficiency has received much less attention.
- Trial name
- MATCOBIND (NCT04083560)
- Testing
- Vit B12
- Where
- 2 sites in India, Nepal
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Sitaram Bhartia Institute of Science and Research
Premature Birth
A Family-Centered Intervention Program for Preterm Infants: Effects and Their Biosocial Pathways
Four hypotheses will be tested in this study: 1. The intervention group performs better in child, parent and transactions outcomes than the control group throughout the follow-up period. 2.
- Trial name
- NCT01807533
- Testing
- Family-centered intervention program, Usual care intervention program
- Where
- 3 sites in Taiwan
- Volunteers
- 275 people
- Sponsor
- National Taiwan University Hospital
Premature Birth
Early Intervention for Preterm Infants
The first aim is to develop a clinic-based intervention program and a home-based intervention program for VLBW preterm infants that have common intervention services but are respectively delivered at clinic and home.
- Trial name
- NCT00173108
- Testing
- clinic-based intervention program and home-based intervention program
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Child Development Disorder
Craniosacral Test and Primitive Reflexes in Infant Neurodevelopment
Question(s): Can active primitive reflexes (APR) and cranial blocks (CB) in healthy children interfere with neurological balance causing psycho-behavioral and cognitive dysfunctions? Design: Cross-sectional and descriptive study…
- Trial name
- NCT05190029
- Testing
- Series of questions to parents of children in a virtual form., Intervention by teachers, Physiotherapeutic evaluation
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
Preterm Birth, Pain
Effects of Music Based Intervention (MBI) on Pain Response and Neurodevelopment in Preterm Infants
Pilot prospective randomized, double blinded, controlled study to test effect of music based intervention (MBI) on pain response and neurodevelopment in preterm infants.
- Trial name
- NCT04286269
- Testing
- Music Based Intervention
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Preterm Infants
Association of Gut Microbiome With Neonatal Complications and Neurodevelopment in Preterm Infants
A prospective cohort study investigating the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
- Trial name
- NCT03841994
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Seoul National University Hospital
Preterm Infant
Preterm Infant Multicentre Growth Study
The purpose of this study is to improve health professionals understanding of preterm infant growth patterns, and to determine if early growth patterns predict risks of adverse metabolic and cognitive outcomes.
- Trial name
- PreMGS (NCT03064022)
- Testing
- Growth
- Where
- 2 sites in Canada
- Volunteers
- 1,275 people
- Sponsor
- University of Calgary
Oral Feeding Outcomes, Neurodevelopment Outcome
Impact of Hospital to Home: Optimizing Preterm Infant Environment for Surgical Neonates and Their Parents (H-HOPE)
Infants born with congenital defects may require major surgery in the neonatal period. These infants are at risk for neurodevelopmental impairments.
- Trial name
- H-HOPE (NCT07372898)
- Testing
- H-HOPE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Brain Injury, Seizures
Study of Bedside EEG to Evaluate Brain Injury in Premature Newborns
This study is evaluating whether a bedside brainwave monitor can be used to detect early brain injury in premature infants.
- Conditions
- Brain Injury, Seizures, Cerebral Palsy
- Trial name
- BrainZ (NCT00516334)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Brigham and Women's Hospital
Prematurity, Iron-deficiency
Darbe Plus IV Iron to Decrease Transfusions While Maintaining Iron Sufficiency in Preterm Infants
In this phase II trial, the investigators overarching goal is to demonstrate the feasibility and potential benefit of darbepoetin (Darbe) plus slow-release intravenous (IV) iron to decrease transfusions, maintain iron sufficiency…
- Conditions
- Prematurity, Iron-deficiency, Iron Deficiency Anemia, Iron Malabsorption
- Trial name
- DIVI (NCT05340465)
- Testing
- Darbepoetin Alfa, Low Molecular Weight Iron Dextran, Ferumoxytol injection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Pregnant Women, Labor Pain
Neuraxial Labor Analgesia and Offspring Neurodevelopment
How perinatal factors affect the long-term development of children has always been an issue of much concern. This study is designed to explore the potential impact of maternal neuraxial labor analgesia exposure on offspring…
- Conditions
- Pregnant Women, Labor Pain, Analgesia, Epidural, Infants
- Trial name
- NCT04964206
- Testing
- Neuraxial labor analgesia, No neuraxial labor analgesia
- Where
- 2 sites in China
- Volunteers
- 4,645 people
- Sponsor
- Dong-Xin Wang
Retinopathy of Prematurity, Neurodevelopmental Abnormality
Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity
The goal of this research project is to identify the long-term outcome of neurodevelopment in patients with retinopathy of prematurity(ROP) and the treatment of anti-vascular endothelial growth factor (VEGF) such as intravitreal…
- Trial name
- NCT05186155
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
General Anesthetics Toxicity, Neurodevelopment
Neurodevelopment of Infants Exposed to General Anesthesia: a Multi-center Investigation
Numerous preclinical evidence has confirmed that most commonly-used general anesthetics can affect neurodevelopment of young animals adversely, causing both structural defect of brain and cognitive impairment.
- Conditions
- General Anesthetics Toxicity, Neurodevelopment, Infant
- Trial name
- GENIUS (NCT03629093)
- Testing
- General Anesthetics
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Preterm Infant Health, Preterm Infant Development
Preterm Infants: Light Effects on Health and Development
Preterm babies cared for in the intensive care nursery are exposed to amounts of light that are very different from the exposures to an unborn baby or the newborn term baby.
- Trial name
- NCT02146287
- Testing
- Cycled Light
- Volunteers
- 121 people
- Sponsor
- Duke University
Development, Vitamin Deficiency
Vitamin B12, Neurodevelopment and Growth in Nepal
Rationale: Globally, vitamin B12 deficiency is one of the most common micronutrient deficiencies. The only relevant source of Vitamin B12 is animal-source foods.
- Conditions
- Development, Vitamin Deficiency, Malnutrition
- Trial name
- BeLive (NCT02272842)
- Testing
- Vitamin B12
- Where
- Nepal
- Volunteers
- 600 people
- Sponsor
- Centre For International Health
Excessive Crying, Prolonged Pain
Assessment of Prolonged Pain in Infants With Excessive Crying: Contribution of Infrared Thermal Imaging - The NEOTHERM Pilot Study
NEOTHERM is a multicenter, prospective, observational pilot study examining whether infrared thermal imaging (ITI) can contribute to the assessment of prolonged pain in infants with excessive crying.
- Trial name
- NEOTHERM (NCT07693179)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis