Clinical trials: Infection and Inflammatory Reaction
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Septic Shock
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.
Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on…
- Trial name
- NCT06152458
- Testing
- Vitamin C
- Where
- Hungary
- Volunteers
- 43 people
- Sponsor
- University of Pecs
Aortic Infections and Inflammations
Risk and Incidence of Aortic Graft and Endograft Infection With BSI
What is the risk of aortic vascular graft and endograft infection in patients with aortic vascular graft/endograft and bloodstream infection?
- Trial name
- NCT05521035
- Where
- Sweden
- Volunteers
- 2,000 people
- Sponsor
- Lund University
Sepsis
Statin for Immunomudulation in Sepsis
The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients
- Trial name
- NCT00452608
- Testing
- amido pill, atorvastatina
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Crohn Disease
Treatment and Fate in Fistulizing Crohn's Disease in a Pediatric Population
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses).
- Trial name
- NCT05759104
- Testing
- Infliximab, Stomy
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Long-term Effects of Thymosin Alpha 1 Treatment
Long-term Prognosis of Patients With Sepsis After Immunotherapy
Current clinical studies of thymosin α1 for sepsis have focused on short-term outcomes (28-day or 90-day mortality), and lack of clinical data on long-term outcomes (3 year mortality) of patients with sepsis after immunotherapy.
- Trial name
- NCT04901104
- Testing
- Thymosin Alpha1
- Volunteers
- 900 people
- Sponsor
- Sun Yat-sen University
Bacteremia
Empirical Antibiotic and Outcome in Community-onset Bacteremia
Empirical antibiotic and outcome in Community-onset Bacteremia Caused by third generation cephalosporin resistant Enterobacteriaceae
- Trial name
- NCT03765749
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Selective Plasma Filtration
Selective Plasmofiltration for Abdominal Septic Shock: a Clinical Ctudy
Group 1: 34 patients received prolonged hemodiafiltration (CVVHDF) on an emergency basis. Group 2: 35 patients received early isolated CVVHDF.
- Trial name
- SPASS (NCT07121647)
- Testing
- renal replacement therapy., early isolated CVVHDF., combined extracorporeal blood purification therapy
- Where
- Russia
- Volunteers
- 101 people
- Sponsor
- Pirogov Russian National Research Medical University
Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: A Pilot RCT
Bacteremia is a leading cause of mortality and morbidity in critically ill adults. Although bacteria in the bloodstream (bacteremia) may arise from variable infectious foci (most commonly central vascular catheter related, lung…
- Trial name
- BALANCE (NCT02261506)
- Testing
- 7 days of adequate antibiotic treatment durations, 14 days of adequate antibiotic treatment durations
- Where
- 17 sites in Canada
- Volunteers
- 115 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Septic Shock
IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis
Pediatric population who suffered from sepsis due to perforated viscus will receive fluid resuscitation guided by either central venous pressure or guided by IVC collapsibility index.
- Conditions
- Sepsis, Septic Shock, Perforated Viscus, Hospitalism in Children
- Trial name
- NCT06833333
- Testing
- Central venous catheter, IVC collapsibility index
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Shock, Septic
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM (Nangibotide) in Patients With Septic Shock
This is a randomised, double-blind, two-stage, placebo controlled study. It is designed to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of 3 doses of nangibotide versus placebo in adult patients…
- Trial name
- NCT03158948
- Testing
- Nangibotide 0.3 mg/kg, Nangibotide 1 mg/kg, Nangibotide 3 mg/kg
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 50 people
- Sponsor
- Inotrem
Nasal Congestion and Inflammations, Rhinitis
Efficacy and Safety of Combination of Brompheniramine and Phenylephrine for the Symptoms Relief of Rhinitis
This is a multicenter clinical trial, phase III, non-inferiority, controlled by active medicine, open, randomized, enroll 538 children, 2 to 12 years old, with acute inflammation upper airway, characterized by nasal congestion…
- Trial name
- NCT01393548
- Testing
- brompheniramine + phenylephrine, Brompheniramine + pseudoephedrine
- Where
- Brazil
- Volunteers
- 879 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Bacteremia
Multicenter Blood Culture Quality Improvement
False positive blood culture results due to specimen contamination with bacteria inhabiting patients' skin is a common problem in emergency departments (EDs) in the United States.
- Trial name
- NCT01413555
- Testing
- Blood Culture QI Program
- Where
- 2 sites in United States
- Volunteers
- 14,889 people
- Sponsor
- Vanderbilt University
Abscess
Trial of Antibiotic Treatment for Skin Abscess in Patients at Risk for Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection
Patients will be enrolled in a multi-center study to prospectively evaluate outcome after treatment for an uncomplicated skin abscess. All patients will receive incision and drainage and wound cultures.
- Trial name
- NCT00829686
- Testing
- Septra
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Sepsis, Septic Shock
Piperacillin Pharmacokinetics in ICU Patients
Antibiotic dosing in critically ill patients poses a challenge for clinicians due to the pharmacokinetic changes seen in this population.
- Trial name
- NCT02478073
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Diabetic Peripheral Vascular Disease
Measurement of Endothelial Function With Peripheral Arterial Tonometry in Patients Undergoing Hyperbaric Oxygen Therapy
The purpose of this clinical study is to test whether or not patients treated with HBOT for diabetic foot ulcers will demonstrate measurable changes of the blood vessel function during the course of HBOT treatments. , i.e.
- Trial name
- NCT02221466
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Ole Hyldegaard
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Artifical Inteligence, Cardiology
Safe and Explainable AI
While current AI technology is suitable for automating some repetitive clinical tasks, technical challenges remain in solving critical and gainful problems in the domains of patient and disease management.
- Conditions
- Artifical Inteligence, Cardiology, Breast Cancer, Sepsis
- Trial name
- NCT06694181
- Testing
- AI-PERSONALIZED CLINICAL DECISION SUPPORT
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
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