Clinical trials: Infertility/Sterility
Male Infertility, Low Sperm Quality
A Clinical Trial to Evaluate the Effects of a Supplement on Markers of Male Fertility
This study will evaluate the effects of the WeNatal For Him supplement on markers of male fertility over a 3-month period. The trial is a single-arm, unblinded study enrolling 40 male participants who will take 3 capsules of the…
- Conditions
- Male Infertility, Low Sperm Quality, Low Testosterone, Low Energy
- Trial name
- NCT07740161
- Testing
- WeNatal For Him Supplement
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- WeNatal
Infertility, Female
Transdermal Testosterone for Poor Responder Patients Undergoing Controlled Ovarian Stimulation Prior to IVF
This study evaluates the efficacy of pre- IVF treatment with transdermal testosterone to enhance ovarian response in poor responders.
- Trial name
- NCT03078569
- Testing
- Testosterone gel
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Anesthesia, Local
A Safety Study of of AG-920 Sterile Topical Ophthalmic Solution
A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects. It is designed to evaluate the ocular safety of a single topical ocular administration of AG-920 sterile topical ophthalmic solution…
- Trial name
- NCT05501860
- Testing
- AG-920
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Self Efficacy
Learning From Online Video Education for Controlled Ovarian Stimulation
The Learning from Online Video Education (LOVE) study seeks to determine if online instructional videos on how to administer medication needed for in vitro fertilization (IVF) help improve the quality of life and reduce stress…
- Trial name
- LOVE (NCT02979990)
- Testing
- Instructional Video, Control Video
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Efficacy of Embryo Transfer Procedure Guided by Transvaginal Ultrasound Versus Abdominal Ultrasound in Oocytes Recipients
The objective of this study is to evaluate the efficacy of embryo transfer procedure guided by transvaginal ultrasound versus abdominal ultrasound in recipients of oocytes as well as the advantages and disadvantages of the new…
- Trial name
- NCT01137461
- Testing
- ultrasound-guided embryo transfer
- Where
- Spain
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Fundació Privada Eugin
Infertility, Pregnancy Related
The Impact of Vaginal Intercourse on Pregnancy Rates After Frozen Embryo Transfer
This study aims to evaluate whether allowing unprotected vaginal intercourse 24 hours after frozen embryo transfer will result in higher ongoing clinical pregnancy rates in comparison to having participants abstain from…
- Conditions
- Infertility, Pregnancy Related, IVF
- Trial name
- NCT03974295
- Testing
- Vaginal unprotected intercourse
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Infertility
Prospective, Randomized Trial Comparing ICSI to Insemination for Non-Male Factor Patients Undergoing PGT-A
Intracytoplasmic sperm injection (ICSI) is a procedure performed during in vitro fertilization (IVF) in which a single sperm is injected directly into an oocyte.
- Trial name
- NCT05548101
- Testing
- ICSI
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Texas Fertility Center
COVID-19, Testosterone Deficiency
SARS-CoV-2, TESTOSTERONE AND MALE FRAGILITY
The hormonal environment (steroid, primarily) could have a very relevant pathophysiological role in association with SARS-CoV-2.
- Conditions
- COVID-19, Testosterone Deficiency, Infertility, Male
- Trial name
- PROTEGGIMI (NCT06177002)
- Testing
- Collection of biological data
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Endometriosis, Infertility
Pesticides and Infertility: Oxidative Stress Via Circulating Cell-free DNA and Gut/Genital Microbiome Signatures in Women With Endometriosis
This project PestiEndoMicro aims to provide an innovative approach, studying endometriosis under the genital and gut microbiota scope.
- Conditions
- Endometriosis, Infertility, Female Fertility, Cell Free DNA
- Trial name
- PestiEndoMicro (NCT07471373)
- Testing
- Circulating DNA analysis, Vaginal microbiota analysis, Endometrial microbiota analysis
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Polycystic Ovarian Syndrome, Infertility, Female
Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women.
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IROP-1 (NCT03598374)
- Testing
- Inositol + Folic acid, Folic acid, Regular intercourses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Thin Endometrium
a-PRP Intrauterine Instillation in Women With Thin Endometrium
This study sought to compare the endometrial thickness among infertile women with a history of thin endometrium together with previous cancellation from IVF/ICSI inspection of intrauterine instillation of autologous-PRP or no…
- Trial name
- PRP(a-PRP) (NCT06234540)
- Testing
- PRP, Standard treatment
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Infertility
Infertility Markers in Serum, Urine, and Follicular Fluid
This study is only collecting specimens from current patients of PENN Fertility Care. The purpose of this investigation is to assess if markers of oxidative stress that are known to be associated with other medical conditions can…
- Trial name
- NCT00194220
- Where
- United States
- Volunteers
- 1,235 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Infertility
Computerized Evaluation of the Endometrial Myometrial Junction During a Natural Menstrual Cyle.
The investigators aim to evaluate the width of the endometrial myometrial zone in participants during natural menstrual cycle by using specific computerized application on 3 dimensions sonographic images of their uteri.
- Trial name
- EMJ (NCT02295917)
- Testing
- Transvaginal sonography
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Infertility
Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters
Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high.
- Trial name
- NCT05978947
- Testing
- ZyMōt Multi 850µL device, Density Gradient Centrifugation Method
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Professor Ernest Hung-Yu Ng
Infertility (IVF Patients), BMI
BMI Versus Body Fat Percentage - Which is the Better Predictor of Fertility Outcomes in IVF Cycles?
The goal of this prospective observational cohort study is to evaluate whether body composition measured using bioelectrical impedance analysis (BIA) (including measures of body fat% and visceral fat) serve as a better predictor…
- Conditions
- Infertility (IVF Patients), BMI, Bioelectrical Impedance Analysis, IVF Outcomes
- Trial name
- NCT07765368
- Testing
- Measurement of BIA (Body Fat and Visceral Fat Percentage)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IWK Health Centre
Hysteroscopy, Pregnancy Rate
Hysteroscopic Metroplasty in Unexplained Infertile Women With Dysmorphic Uterus
The correlation between dysmorphic uterus and infertility still remains enigmatic. We aim to evaluate the reproductive outcomes of metroplasty via office hysteroscopy in unexplained infertile women with dysmorphic uterus with…
- Conditions
- Hysteroscopy, Pregnancy Rate, Abortion, Ectopic Pregnancy
- Trial name
- COH/IUI (NCT03579550)
- Testing
- office hysteroscopic metroplasty intervention arm
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Bulent Haydardedeoglu
Women Who Suffer From Hydrosalpinx That is Causing Infertility and Whom Want a Safer Way of Treamtent
Use of Essure® Micro-inserts in Women With Hydrosalpinx Prior to In Vitro Fertilization: A Prospective, Multicenter, International Feasibility Study
The purpose of this study is to gather safety data related to the use of Essure® micro-inserts in women with hydrosalpinx prior to in vitro fertilization and during pregnancy and to collect data with regard to implantation rates…
- Trial name
- NCT01221974
- Testing
- Essure Micro Insert
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Reproductive Science Center
Infertility, Female, Anesthesia Awareness
Preoperative Anxiety at Oocyte Retrieval
This study evaluated the effects of preoperative anxiety and dosage of anesthesia on IVF success. Half of participants according to the recorded Beck's Anxiety Inventory (BAI) score: a low-anxiety group, while the other half…
- Conditions
- Infertility, Female, Anesthesia Awareness, Anxiety State
- Trial name
- NCT03134651
- Testing
- Monitoring brain function, propofol
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Trakya University
Infertility
Vitrification and Slow Freezing for Cryopreservation of Blastocyst
Improvement in the treatment of infertility by Assisted Reproductive Techniques (ART) allows single embryo transfer to be applied without compromising pregnancy rates after the first in vitro fertilization (IVF) or Intra…
- Trial name
- NCT02068924
- Testing
- Slow freezing versus vitrification
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
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