Clinical trials: Infertility Assisted Reproductive Technology
Infertility, Female, Endometriosis
Predicting Endometrial Receptivity for Optimal Reproductive Management
The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for…
- Trial name
- PERFORM (NCT04107129)
- Testing
- Endometrial Biopsy, Euploid embryo transfer, Blood sample
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Infertility, Female
Junctional Zone and Its Relation to Outcomes in Assisted Reproductive Technology
The junctional zone (JZ) is an internal layer of the myometrium, with unique characteristics that allow its visualization as a hypoechogenic structure in three-dimensional (3D) ultrasound.
- Trial name
- NCT04878224
- Where
- Portugal
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Lisboa Norte
Male Infertility, Advanced Paternal Age
Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age
Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased.
- Conditions
- Male Infertility, Advanced Paternal Age, Assisted Reproductive Technology
- Trial name
- IVF (NCT07605182)
- Testing
- LensHooke® CA0 sperm sorting device, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 378 people
- Sponsor
- Vietnam Military Medical University
Infertility, Oocyte
Improvement of Live Babies Rates After ICSI, Using cpFT
Demonstrate the improvement of the live births rate after ICSI by supplementing the pre-ICSI incubation medium of oocytes and that of preimplantation embryos with cpFT at the 1st embryo transfer for women under 37 years old.
- Conditions
- Infertility, Oocyte, Pregnancy
- Trial name
- FERTICSI (NCT04954274)
- Testing
- Cyclic peptide Fertiline
- Where
- France
- Volunteers
- 366 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Male Infertility, Infertility (IVF Patients)
Male Infertility and Assisted Reproductive Technologies Research Biobank
The objective of this research is to build a biobank of biological male specimens used for diagnostics and treatment of infertility or assisted reproductive technologies (ART).
- Trial name
- MARK (NCT06880302)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
Pharmacogenetic Algorithm for Individualized Controlled Ovarian Stimulation
In this study, the investigators will evaluate genetic variation or polymorphisms between individuals submitted to IVF/ICSI cycles, and how these variations influence response to COS and pregnancy outcomes.
- Trial name
- NCT03149536
- Testing
- Pharmacogenetic test
- Volunteers
- 1,350 people
- Sponsor
- Clínica Origen
Progesterone Supplementation in Women Undergoing ART
Clinical Safety Study of the Progesterone Vaginal Ring in Women Undergoing Assisted Reproductive Technology Procedures
The purpose of the study is to assess the safety of Progesterone Vaginal Ring (PVR) in women undergoing fresh embryo transfer (ART).
- Trial name
- SARA (NCT03565211)
- Testing
- Progesterone vaginal ring
- Where
- 15 sites in United States
- Volunteers
- 352 people
- Sponsor
- Ferring Pharmaceuticals
Adenomyosis of Uterus, Infertility Assisted Reproductive Technology
Does The Addition Of Letrozole To Ultra-Long GnRH Agonists Help Adenomyosis Patients in ART? The AURA Trial
The AURA Trial seeks to improve fertility treatment for women affected by a condition known as adenomyosis. Adenomyosis often leads to heavy menstrual bleeding, pelvic pain, dyspareunia and can make it more difficult to achieve…
- Trial name
- AURA (NCT06985186)
- Testing
- Ultra-Long GnRH Agonists + Letrozole, Ultra-Long GnRH Agonists
- Where
- Spain
- Volunteers
- 162 people
- Sponsor
- University of Palermo
Primary Maternal and Neonatal Outcomes; Assisted Reproductive Technology
Retrospective Comparison of Pregnancy Outcome of Infertile Patients After Fresh and Warmed Single Blastocyst Transfer From 2014 to 2018.
The investigators retrospectively analysed the maternal and neonatal outcomes following a single fresh blastocyst transfer and a single warmed blastocyst transfer from procedures performed between 2014 and 2018 in a tertiary…
- Trial name
- NCT04310761
- Testing
- one single blastocyst transfer, both fresh and warmed
- Volunteers
- 4,613 people
- Sponsor
- Istituto Clinico Humanitas
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Quantifying Uterine Elastography in Menstruating Women
This study is aiming to characterize the elasticity of the female reproductive tract including the uterus, cervix and ovary using shear wave elastography at different times during the menstrual cycle and define the standard…
- Trial name
- QUEST (NCT06816381)
- Testing
- Shear wave elastography measurements
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
Outcomes of Couples After Failed PGD Management: A Single-Center Study at the Paris PGD Center (Antoine Béclère - Necker)
Preimplantation genetic testing (PGT) is a reproductive genetic technique aimed at preventing the transmission of severe genetic disorders.
- Trial name
- DECOPI (NCT07371312)
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility
The Role of Progesterone and PIF for Successful Implantation and On-going Pregnancy in Assisted Reproductive Technology
The aim of this study is to achieve a more profound understanding of the endocrine alteration in luteal progesterone level after gonadotrophin stimulated IVF/ICSI cycles and to explore the optimal progesterone level needed for…
- Trial name
- NCT02129998
- Testing
- IVF/ICSI treatment
- Where
- Denmark
- Volunteers
- 873 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
IVF Outcomes, Prediction Models
Machine-Learning Prediction of Pregnancy Outcomes After Assisted Reproductive Treatments
The goal of this observational study is to develop and validate a machine-learning model to predict pregnancy outcomes in women with a positive pregnancy test following assisted reproductive treatment (ART), with the primary…
- Conditions
- IVF Outcomes, Prediction Models, Infertility Assisted Reproductive Technology, Live Birth
- Trial name
- NCT07855783
- Testing
- Machine-Learning Model for Prediction of Pregnancy Outcomes
- Where
- 2 sites in Croatia
- Volunteers
- 2,200 people
- Sponsor
- BetaPlus Center for Reproductive Medicine
Anxiety, Assisted Reproductive Treatments
Virtual Reality for Anxiety Relief in Infertile Women
This study examines the impact of virtual reality (VR) applications on anxiety levels before and after embryo transfer procedures.
- Conditions
- Anxiety, Assisted Reproductive Treatments, Women, VR
- Trial name
- NCT07020975
- Testing
- VR Glasses
- Where
- Cyprus
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cyprus Aydin University
Infertility, Assisted Reproductive Technology
Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?
Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique
- Conditions
- Infertility, Assisted Reproductive Technology, IVF
- Trial name
- NCT03756857
- Testing
- Afterload Transfer, Trial followed by transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem Kadiköy Hospital
Egg Donation, Infertility Assisted Reproductive Technology
Egg Donation at the Assisted Reproductive Technology (ART) Center of the Nancy University Hospital
Since the 2021 revision of French bioethics laws, access to assisted reproductive technologies (ART) has expanded, leading to a significant increase in gamete donation requests.
- Trial name
- DONOVO-Nancy (NCT07468331)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Central Hospital, Nancy, France
In Vitro Fertilization, Infertility Assisted Reproductive Technology
Assessment of Reproductive Outcomes in Non-Male Factor Infertility Patients: Conventional in Vitro Fertilisation Versus Intracytoplasmic Sperm Injection
The aim of this clinical trial is to evaluate the efficiency of two fertilization techniques used in Assisted Reproduction: conventional In Vitro fertilization (cIVF) and Intracytoplasmic Sperm Injection (ICSI), in terms of…
- Trial name
- NCT06670586
- Testing
- conventional in vitro fertilization, intracytoplasmic sperm injection (ICSI)
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Maria Dolores Cuquerella Fernandez-Vazquez
Infertility
Vascular Dysfunction in Offspring of Assisted Reproduction Technologies
The prevalence of infertility has been estimated at 9% worldwide. The steadily increasing use of assisted reproductive technologies (ART) has allowed millions of infertile couples to have children.
- Trial name
- NCT00837642
- Testing
- Transthoracic echocardiography
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Infertility, Female
Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-2)
This trial investigates the effects of FE 999049 compared to placebo.
- Trial name
- RITA-2 (NCT03738618)
- Testing
- Follitropin delta
- Where
- 24 sites in United States
- Volunteers
- 588 people
- Sponsor
- Ferring Pharmaceuticals
Sterility, Infertility
Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology
This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.
- Trial name
- NCT03177122
- Testing
- Myo-inositol
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center