Clinical trials: Inflammation
Periodontal Disease, Pregnancy
Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic Biomarkers
Periodontal disease is a chronic inflammatory condition that affects the tissues supporting the teeth and may contribute to systemic inflammation and oxidative stress.
- Conditions
- Periodontal Disease, Pregnancy, Preterm Birth
- Trial name
- NCT07699978
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Healthy Infants, Infants With an Inflammatory Condition
Novel Isotope Dilution Technique to Assess Vitamin A Status
Background: There is no reliable method for vitamin A (VA) assessment for infants and young children. Serum VA concentration is not an authenticate indicator of VA status, while existing deuterium- VA isotope dilution methods to…
- Trial name
- NCT03000543
- Testing
- Vaccine
- Where
- 2 sites in Bangladesh
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Sepsis, Retinal Microcirculation Disorder
Ocular Microvascular Changes in Patients With Sepsis
This study evaluates differences in the ocular microcirculation between septic patients and healthy subjects and the course of ocular microvasculature in survivors and non-survivors over a 24 hours period of time in septic…
- Conditions
- Sepsis, Retinal Microcirculation Disorder, Conjunctiva; Disorder
- Trial name
- NCT04214743
- Testing
- Incident dark field videomicroscope from Braedius, Fundus camera from Optomed
- Where
- Lithuania
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Headache Disorders
Assessment of Inflammation in Primary Headaches
Headache is the most common neurological complaint accounting for % 1 to % 4 in the emergency department (ED).Every year, nearly one million people with headache attacks have been consulted by healthcare professionals at the…
- Trial name
- NCT04891848
- Testing
- inflammation
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Inflammatory Markers
Lycopene-rich Juice Intervention to Reduce Inflammatory Markers Among Adults With Obesity
The purpose of this research is to see whether a finger scanning device can accurately measure carotenoids, the colorful substances in fruits and vegetables, in people's skin.
- Trial name
- NCT07120035
- Testing
- Lycopene-rich juice
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Systemic Inflammatory Response Syndrome
Effects of Free Fatty Acids and 3-hydroxybutyrate on Protein, Glucose, Lipid Metabolism and Intracellular Signals.
The investigators hypothesize that the investigators can detect protein-sparing effects of administration of the ketone 3-hydroxybutyrate and free fatty acids during simulation of an acute inflammatory disease.
- Trial name
- NCT01752348
- Testing
- Endotoxin, US standard reference E.coli
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Uremia, Inflammation
Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients
Subclinical inflammation is a common phenomenon in patients receiving maintenance hemodialysis (MHD). This is because various pro-inflammatory cytokines are promoted due to metabolic acidosis, volume overload, and / or…
- Trial name
- NCT01356433
- Testing
- oral vitamin C
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Pulmonary Inflammation, Cystic Fibrosis
Modulation of Intestinal and Pulmonary Inflammation by Lactobacillus Diet Supplementation in Pediatric Cystic Fibrosis
Pulmonary inflammation is an independent risk factor for disease progression in cystic fibrosis patients (CF). Yet, no effective treatment is known to reduce this detrimental inflammation.
- Conditions
- Pulmonary Inflammation, Cystic Fibrosis, Microbiota
- Trial name
- MoHuM-1 (NCT01837355)
- Testing
- Lactobacillus rhamnosus
- Where
- Switzerland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Depression
Mechanisms Underlying Antidepressant Effects of Physical Activity
It is well established that any level of physical activity can help prevent and treat depression, with more strenuous activity having a greater effect.
- Trial name
- LIFE (NCT06387732)
- Testing
- Aerobic exercise, Stretching and relaxation
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University College, London
Cancer Survivor, Pediatric Cancer
Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors.
- Trial name
- NCT02032121
- Testing
- Blood specimen, Echocardiography
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Miami
Inflammation
Inflammatory Response and Pregnancy Outcome in Women With Type 2 Diabetes or Overweight
Purpose: The purpose of this study is to determine if disturbances in cytokines or factors of the metabolic syndrome, can predict complications in pregnancy, birth, and the perinatal period in pregnant women with type 2 diabetes…
- Trial name
- NCT00311064
- Testing
- physical activity
- Where
- Denmark
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Lymphedema, Secondary Lymphedema
Biological Profile of Primary and Secondary Lymphedema: Inflammatory, Endothelial, Metabolic, Lymphatic, and Fibrotic Markers
This observational, cross-sectional study aims to characterize the biological profile of primary and secondary lymphedema by investigating five interconnected biological domains: T helper 2 (Th2)-related inflammation, endothelial…
- Trial name
- LYMPH5 (NCT07770399)
- Where
- Slovenia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hypertension, Obesity
Effect of EGCG on the Body's Response to Insulin
This study will examine whether epigallocatechin gallate (EGCG), a major component of green tea, affects how the body responds to insulin in healthy and obese people.
- Conditions
- Hypertension, Obesity, Type 2 Diabetes, Insulin Resistance
- Trial name
- NCT00434499
- Testing
- EGCG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Respiratory Inflammation, Systemic Inflammation
Woodsmoke Exposure and Cardiovascular Function
Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract.
- Trial name
- NCT01488500
- Testing
- Bronchoscopy
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
COVID-19, Critical Illness
Immune Modulation by Exosomes in COVID-19
Following whole blood stimulation with mesenchymal stem cell derived exosomes, immune phenotype, cytokine release and mRNA expression patterns from critically ill patients with COVID-19 will be determined.
- Conditions
- COVID-19, Critical Illness, Hypercytokinemia, Lung Fibrosis
- Trial name
- IMECOV19 (NCT05191381)
- Testing
- Application of exosomes in a whole blood assay
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Pre-diabetes, Metabolic Syndrome
Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers
The primary goal is to to characterize the effects of consuming 1 avocado fruit 7 days / week (5-7 days is acceptable) compared to a no avocado relatively low fat, carbohydrate control treatment over a 12 week period on insulin…
- Trial name
- AV2 (NCT02695433)
- Testing
- Active, Control
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Gingivitis
Personalized 3D Visualization for Oral Hygiene and Motivation in Adults With Gingivitis
This study evaluated whether personalized three-dimensional images of possible future changes in the gums could improve oral hygiene and motivation in adults with gingivitis.
- Trial name
- NCT07826715
- Testing
- Conventional Oral Hygiene Education, Three-Dimensional Animation-Based Oral Hygiene Education, Personalized Three-Dimensional Visualization With Motivational Discussion
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Birth Asphyxia, Very Low Birth Weight Baby
Naushero Feroze Neonatal Survival Project
The present study will be carried out in close collaboration with the National Program for Lady Health Workers, a Ministry of Health program with 100,000 Lady Health Workers covering 60% of the rural population of Pakistan.
- Conditions
- Birth Asphyxia, Very Low Birth Weight Baby, Neonatal Sepsis
- Trial name
- AKU (NCT01350765)
- Testing
- Intervention, Control
- Where
- Pakistan
- Volunteers
- 37,201 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Obesity, Type 2 Diabetes
Hyperbaric Oxygen Treatment Ameliorates Insulin Resistance
Obesity is an epidemic in Western society and is the biggest risk factor for insulin resistance and type 2 diabetes. The investigators have preliminary evidence showing that hyperbaric oxygen therapy rapidly increases insulin…
- Trial name
- HOTAIR (NCT01361971)
- Testing
- Hyperbaric Oxygen Treatment
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
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