Clinical trials: Inflammatory Marker
Atherosclerosis
Monocyte Activation in Preclinical Atherosclerosis
The study of proinflammatory and anti-inflammatory cytokines and chemokines expression profiles in human monocytes to identify new effective biomarkers that have the best diagnostic potential in asymptomatic atherosclerosis.
- Trial name
- MAPA (NCT02126280)
- Testing
- In vitro estimation of individual reactivity of monocytes
- Where
- Russia
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Institute for Atherosclerosis Research, Russia
Uremia, Inflammation
Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients
Subclinical inflammation is a common phenomenon in patients receiving maintenance hemodialysis (MHD). This is because various pro-inflammatory cytokines are promoted due to metabolic acidosis, volume overload, and / or…
- Trial name
- NCT01356433
- Testing
- oral vitamin C
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
IBD, Crohns Disease
IBDSL Biobank Project. Molecular Markers for Diagnosis and Therapy Response in IBD.
The IBD South Limburg (IBDSL) project was initially designed as a prospective population based cohort study. Since 1991, all new IBD cases have been enrolled in the cohort and prospectively followed.
- Conditions
- IBD, Crohns Disease, Ulcerative Colitis
- Trial name
- IBDSL (NCT02130349)
- Where
- 3 sites in Netherlands
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dietary Fiber, Gastrointestinal Microbiome
Luxembourgish Fiber Cohort
Many human populations across the world are deficient in the intake of dietary fiber. This decline in fiber consumption parallels an increase in prevalence of a multitude of diseases (e.g. colorectal cancer, multiple sclerosis).
- Conditions
- Dietary Fiber, Gastrointestinal Microbiome, Healthy Volunteers
- Trial name
- Lux-FiCo (NCT04352231)
- Testing
- High Fiber Diet Intervention, Low Fiber Diet Intervention
- Where
- 2 sites in Luxembourg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Sepsis, Septic Shock
Early and Late Neutrophil CD64 and Monocyte HLA-DR as Biomarkers for Septic Shock
Study Summary: Neutrophil CD64 \& Monocyte HLA-DR in Septic Shock What is studied? Doctors looked at two blood markers: Neutrophil CD64 (nCD64): rises quickly when the body fights infection.
- Trial name
- NCT07401329
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
Autoinflammatory Disease, Autoimmune Diseases
Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases
A multi-centre, prospective study to study cytokine profiles and other potential disease-specific biomarkers in patients with presumed or confirmed diseases of systemic inflammation The goal of this prospective, observational…
- Conditions
- Autoinflammatory Disease, Autoimmune Diseases, Inflammation
- Trial name
- FEBRIS (NCT05670301)
- Testing
- cytokine and lipidomic profiling
- Where
- 7 sites in Belgium
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Postoperative Delirium, Pediatric Anesthesia
Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision
Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data…
- Conditions
- Postoperative Delirium, Pediatric Anesthesia, Inflammatory Biomarkers
- Trial name
- NCT07323485
- Testing
- Measurement of Preoperative Inflammatory Biomarkers
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Biomarkers, Neurodevelopmental Disorders
Predictive BioMArkers of AlTERed NeurologicAL Trajectories Consequent to PrenataL InflammatorY Insults
Inflammation during pregnancy represents an important risk factor for the development of neuropsychiatric disorders in the offspring.
- Conditions
- Biomarkers, Neurodevelopmental Disorders, Inflammation, Brain
- Trial name
- MATERNALLY (NCT06852703)
- Testing
- Infection during pregnancy
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Relapsing Multiple Sclerosis, Multiple Sclerosis
Sema 4A as a Marker for Inflammatory Disease in Multiple Sclerosis
Measure serum and cerebrospinal fluid Sema4A levels in female subjects with newly diagnosed and untreated relapsing multiple sclerosis, clinically stable relapsing multiple sclerosis receiving disease modifying therapy, relapsing…
- Trial name
- Sema4A MS (NCT05077956)
- Testing
- Cerebrospinal and Blood Serum Semaphorin 4A Levels
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Providence Health & Services
Metabolic Syndrome
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.
- Trial name
- NCT00819403
- Testing
- simvastatin, ezetimibe/simvastatin
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Inflammatory Disease, Genetic Disease
Molecular Diagnosis of Systemic Autoinflammatory Diseases
Systemic autoinflammatory diseases (SAIDs) are a set of rare clinically and genetically heterogeneous conditions. The project proposes to identify novel genes and specific signatures in subgroups of patients with SAIDs.
- Conditions
- Inflammatory Disease, Genetic Disease, Somatic Mutation, Molecular Sequence Variation
- Trial name
- SAIDiag (NCT05364294)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Low Back Pain
Effects of Strength Training in Chronic Low Back Pain Patients
Although it is known that chronic low back pain (CLBP) have a multifactorial etiology, the investigations about it are mostly specific to each investigation area, making difficult to understand this complex condition.
- Trial name
- NCT03326362
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Crohn Disease
Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease
This research study will evaluate if specific blood, stool and MRI tests can tell the difference between bowel wall inflammation without scarring and bowel wall inflammation with scarring that can cause bowel blockages requiring…
- Trial name
- NCT04088773
- Testing
- blood biomarkers, stool biomarkers, MRI imaging
- Where
- 4 sites in United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Hypoxia, Altitude
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal…
- Trial name
- NCT06204731
- Testing
- Exercise and environmental conditions
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
COVID 19, Inflammatory Status
FOUND - Ancillary Study to Smile Protocol NCT03654105
During the current pandemic, in Italy the majority of asymptomatic or pauci-symptomatic COVID-19 cases were not identified nor diagnosed and this fact caused a decrease in the effectiveness of the various containment measures…
- Trial name
- FOUND (NCT04441814)
- Where
- Italy
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Herper Zoster
Biomarker Study in Patients With Herpes Zoster
Investigators performed this study to investigate the expression levels inflammatory cytokine and neurotransmitters (calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal peptide (VIP), and β-endorphin)…
- Trial name
- NCT05685797
- Testing
- Herpes zoszter (acute)with inter vention
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keimyung University Dongsan Medical Center
Bipolar Disorder, Unipolar Depression
Development of a Software Tool, Using Artificial Intelligence, That Integrates Clinical, Biological, Genetic and Imaging Data to Predict Diagnosis and Outcome of Depressed Patients in Order to Enhance Prognosis and Limiting Healthcare Costs.
Based on robust evidence from literature, the investigators hypothesize the presence of disease-specific neurobiological underpinnings for bipolar and unipolar disorder, which may serve as biomarkers for differential diagnosis.
- Trial name
- NCT05801562
- Where
- Italy
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Disease (IBD), Dysbiosis
Oral Microbiota Dysbiosis in IBD
This study aims to provide new insights into oral microbiota dysbiosis and IBD. Given the strong association between oral health, microbiome composition, and IBD, all participants will undergo an oral evaluation program conducted…
- Trial name
- MIBD (NCT06980818)
- Testing
- No intervention
- Where
- Portugal
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- ULS Viseu Dão Lafões