Clinical trials: Inflammatory Marker
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Athletic Injuries
Effect of Vitis Vinifera Extract on Oxidative Stress, Inflamatory Biomarkers and Hormones in High Trained Subjects
There is evidence that intense physical activity has a potential effect on thrombotic events due to catecholamine release. The hormones leptin and adiponectin have been used as markers of cardiovascular risk, but they are few and…
- Trial name
- NCT01875497
- Testing
- grape fruit (vitis vinifera) extract in capsule with 205 mg
- Where
- Brazil
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Body Composition, Beneficial, Oxidative Stress
Phase Angle and Body Composition, Inflammatory and Oxidative Stress Biomarkers.
The main purpose of the present study was to investigate the effects of 12 weeks of resistance training (RT) on phase angle (PhA), body composition, inflammatory and oxidative stress biomarkers, in older women and to evaluate…
- Conditions
- Body Composition, Beneficial, Oxidative Stress, Acute and Chronic Inflammation
- Trial name
- NCT02940145
- Testing
- Resistance Training
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Sepsis
Circulating microRNAs as Biomarkers of Sepsis
MicroRNA has been demonstrated to play a crucial role in regulating cell processes. Recently, microRNA was identified to exist in human serum or plasma, and it might be related to certain diseases.
- Trial name
- NCT00862290
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Treatment-resistant Depression (TRD), Major Depression
Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression
Treatment-resistant depression (TRD) is a major clinical challenge affecting a substantial proportion of patients with major depressive disorder who do not adequately respond to conventional antidepressant treatments.
- Trial name
- TRD-BIOTMS (NCT07673913)
- Testing
- Intermittent Theta Burst Stimulation (iTBS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Neurodegenerative Diseases
Big Data and Genomic Imaging for the Development of Biomarkers and Nanovector Drugs Innovative for Diagnosis and Therapy of Inflammatory Processes in Dementia
The correlation between data obtained by "imaging" in patients with neurodegenerative diseases characterized by inflammation and the presence in the peripheral blood of the same patients "biopsies liquid biopsies" of specific…
- Trial name
- BigImAGING (NCT05761535)
- Testing
- Magnetic Resonance (MR) and positron emission tomograph (PET) imaging analyses
- Where
- Italy
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Dietary Fiber, Gastrointestinal Microbiome
Luxembourgish Fiber Cohort
Many human populations across the world are deficient in the intake of dietary fiber. This decline in fiber consumption parallels an increase in prevalence of a multitude of diseases (e.g. colorectal cancer, multiple sclerosis).
- Conditions
- Dietary Fiber, Gastrointestinal Microbiome, Healthy Volunteers
- Trial name
- Lux-FiCo (NCT04352231)
- Testing
- High Fiber Diet Intervention, Low Fiber Diet Intervention
- Where
- 2 sites in Luxembourg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Inflammatory Bowel Diseases
The Role of Peripheral and Tissue Chitinase 3-like 1 Protein Levels as a Bio-marker in IBD
The digestive system may be involved in various pathologic conditions, with different inflammatory, metaplastic and neoplastic aspects.
- Trial name
- NCT03154905
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Placental Dysfunction, Prenatal Stress
Effects of Pregnancy-Specific Anxiety on Placental Inflammatory and Oxidative Stress Response and Birth Outcomes
Explore the associations of prenatal maternal anxiety to placental histologic findings, and the pro-inflammatory, anti-inflammatory, and immunoregulatory cells found in the placenta and determine the effect of maternal anxiety on…
- Trial name
- MOMSPlacenta (NCT04993742)
- Testing
- MOMS Intervention
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Metabolic Syndrome
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment
To determine whether the combination of ezetimibe and simvastatin improves biomarkers of atherothrombosis compared to simvastatin alone in patients with the metabolic syndrome.
- Trial name
- NCT00819403
- Testing
- simvastatin, ezetimibe/simvastatin
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Overweight/Obesity, Glucose Intolerance
Effects of 3 Months of Supervised Exercise Training
The incidence of type 2 diabetes is increasing worldwide. Because of cardiovascular morbidity and mortality associated with type 2 diabetes, it is imperative to propose methods of prevention and this in early stage of abnormal…
- Conditions
- Overweight/Obesity, Glucose Intolerance, Type 2 Diabetes, Sedentarity
- Trial name
- NCT01349166
- Testing
- Behavior: Supervised physical training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Depressive Disorder, Treatment-Resistant
Brain Connectivity and Inflammatory Markers During Short-Term Psychotherapy for Treatment-Resistant Depression
Some adults continue to experience depression despite treatment with antidepressant medicines. This study aimed to explore relationships between depression symptoms, brain function, and blood markers of inflammation, and changes…
- Trial name
- NCT07847242
- Testing
- Short-Term Dynamic Psychotherapy, Mindfulness-Based Cognitive Therapy
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Korea University Ansan Hospital
Inflammatory Bowel Diseases
Identify Specific Peripheral Blood Mononuclear Cell (PBMC) MiRNA as Biomarkers for Inflammatory Bowel Disease (IBD)
To find high sensitivity and specificity biomarkers to better diagnose and monitor progression of inflammatory bowel disease (IBD).
- Trial name
- NCT04256538
- Where
- China
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neuroinflammatory Response, Nerve Injury
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1.
- Conditions
- Neuroinflammatory Response, Nerve Injury, Nerve Damage, Neurotoxicity
- Trial name
- NCT06021262
- Testing
- exposure to organophosphates
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Crohn Disease
Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease
This research study will evaluate if specific blood, stool and MRI tests can tell the difference between bowel wall inflammation without scarring and bowel wall inflammation with scarring that can cause bowel blockages requiring…
- Trial name
- NCT04088773
- Testing
- blood biomarkers, stool biomarkers, MRI imaging
- Where
- 4 sites in United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Periodontal Diseases, Periodontitis
The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodontal Disease.
Periodontal disease is an infectious pathology that consists of the destruction of the gums and supporting structures around the teeth. There are several mechanisms involved in this process.
- Trial name
- NCT04404335
- Testing
- Crevicular fluid analysis by using ELISA testing.
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Sepsis, Early Diagnosis
The Biomarker Prediction Model of Septic Risk in Infected Patients
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Sepsis is associated with high mortality because of the complex mechanisms.
- Conditions
- Sepsis, Early Diagnosis, Biomarkers
- Trial name
- NCT05095324
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Severe Sepsis
Platelet-associated Inflammation in Severe Sepsis
Sepsis represents a serious public health issue characterized by a complex inflammatory response. In addition to their hemostatic role, platelets display inflammatory functions by secreting a variety of immunomodulatory factors…
- Trial name
- PlatISSep (NCT03029039)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne