Clinical trials: Insulin
Hyperlipidemia, Insulin Resistance
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
Background: There is general agreement that statin-treatment of patients to lower plasma cholesterol levels can increase the incidence of type 2 diabetes mellitus (T2D) in some individuals1-5.
- Conditions
- Hyperlipidemia, Insulin Resistance, Type 2 Diabetes
- Trial name
- NCT02437084
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
Non-alcoholic Fatty Liver Disease, Insulin Resistance
Selenoprotein P and Non-alcoholic Fatty Liver Disease
The pathogenesis of nonalcoholic fatty liver disease has not been fully elucidated. The most widely supported theory implicates insulin resistance as the key mechanism leading to hepatic steatosis, and perhaps also to…
- Trial name
- NCT01257685
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Korea University
Diabetes Mellitus
Pharmacokinetic and Glucodynamic Crossover Study of Subcutaneously (SC) Administered Insulin Lispro + Recombinant Human Hyaluronidase (rHuPH20) and Regular Human Insulin + rHuPH20 Compared to Insulin Lispro Alone
Insulin lispro and regular human insulin are Food and Drug Administration (FDA)-approved medications for the treatment of diabetes mellitus.
- Trial name
- NCT00862849
- Testing
- Insulin Lispro, Regular Human Insulin, rHuPH20
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Halozyme Therapeutics
Weight Loss, Metabolic Syndrome
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
The use of continuous glucose monitoring (CGM) in earlier data has inspired behavioral changes leading to improved adherence to an exercise plan in individuals and eating habits in people with diabetes.
- Conditions
- Weight Loss, Metabolic Syndrome, Diabetes Mellitus, Type 2, Central Obesity
- Trial name
- NCT05874635
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Cancer Survivors, African Americans
Grateful Strides Toward Physical Activity and Well-Being for Black Breast Cancer Survivors
This pilot study will assess the feasibility of a gratitude intervention to promote physical activity, and well-being and positively impact biomarkers of health among older African American breast cancer survivors.
- Conditions
- Cancer Survivors, African Americans, Women, Psychology, Positive
- Trial name
- NCT05473026
- Testing
- Gratitude Intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Florida
Metabolic Syndrome
Safety, Tolerability and Pharmacokinetic Study of MB12066 in Healthy Male Volunteers
The purpose of this study is to investigate the safety and tolerability of MB12066 after multiple dose and to investigate the pharmacokinetic characteristics of MB12066 after multiple dose.
- Trial name
- NCT02338856
- Testing
- MB12066 200mg
- Where
- South Korea
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Congenital Hypothyroidism, Metabolic Syndrome
Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism
We propose a multicenter prospective study to define the prevalence and severity score of metabolic syndrome in a prepubertal pediatric cohort with congenital hypothyroidism, compared to a healthy and normal-weight pediatric…
- Trial name
- IpoMet (NCT07126353)
- Testing
- prospective observational study (clinical, hormonal and auxological data)
- Where
- Italy
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Buzzi Children's Hospital
Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH)
How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver
Steatotic liver disease associated with metabolic dysfunction (MASLD) is a disease caused by excess fat storage in the liver. Excessive fat delivery to the liver and MASLD typically occurs in people with abdominal obesity and…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH), Type 1 Diabetes Mellitus
- Trial name
- AGL14 (NCT07133854)
- Testing
- Imaging PET/MRI, Stable isotope infusions, meal test
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Metabolic Syndrome, Insulin Resistance
Effect of a Synergistic Food Basket on Metabolic Syndrome Risk
The study evaluates the effect of a diet combining two different functional concepts on markers associated to cardiometabolic risk.
- Trial name
- NCT01527253
- Testing
- Synergistic food basket
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity, Non-Alcoholic Fatty Liver Disease
Effect of Timed-Restricted Eating on Metabolic Health
We aim to determine the effect of combined isocaloric time restricted eating and meal timing on metabolic health, liver fat, functional brain networks, inflammation, and sleep pattern/quality in subjects with obesity and insulin…
- Conditions
- Obesity, Non-Alcoholic Fatty Liver Disease, Insulin Resistance
- Trial name
- TREAT (NCT06061042)
- Testing
- Early time restricted eating, Late time restricted eating
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Alzheimer Disease, Mild Cognitive Impairment
Investigating Brain Insulin Resistance in Alzheimer Disease with IntraNasal Insulin : a Multimodal Neuroimaging Study
Using simultaneous multimodal neuroimaging (FDG-PET, fMRI, EEG), this research project will aim to further investigate in vivo brain insulin signalling by exploring the effects of acute INI administration on neurometabolic and…
- Trial name
- Memori³ (NCT06391853)
- Testing
- Insulin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Cardiovascular Complications, Leukemia
Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell Transplant
RATIONALE: Gathering information about how often metabolic syndrome occurs in young survivors of childhood leukemia who have undergone stem cell transplant may help doctors learn more about the disease and the long-term effects…
- Conditions
- Cardiovascular Complications, Leukemia, Long-term Effects Secondary to Cancer Therapy in Children, Metabolic Syndrome
- Trial name
- NCT00920842
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Diabetes, Pre-diabetes
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
The objective of this clinical trial is to explore whether L-arginine supplementation with 3.32g/day may enhance antioxidant defenses in overweight and obese patients with pre-diabetes and metabolic syndrome, possibly providing…
- Conditions
- Diabetes, Pre-diabetes, Metabolic Syndrome
- Trial name
- L-BIOARG (NCT06686069)
- Testing
- bioarginina zero
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes Mellitus
T Cell Validation Study Using Blood Samples From Subjects With Recent Onset Type 1 Diabetes Mellitus
Type 1 diabetes is a condition that is caused in part by an abnormality of the immune system which occurs when T cells, which are part of the immune system, damage the insulin secreting cells (islet cells) in the pancreas.
- Trial name
- NCT00212329
- Testing
- T Cell Proliferation and Autoreactivity Assays, Cellular Immunoblot Assays, Tetramer Studies
- Where
- 14 sites in United States, United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
Energy Balance Following Islet Transplantation
Islet transplantation may be appropriate in up to 10% of adults with Type 1 diabetes who suffer repeated episodes of hypoglycaemia with severely impaired awareness of hypoglycaemia (IAH) (1).
- Trial name
- EBFIT (NCT03063229)
- Testing
- Accelerometer, Anthropomentry, Blood tests
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Appetite and General Nutritional Disorders
Advanced Protein-based Program for Effective Treatment of Appetite Regulation and Obesity
INTRODUCTION: Obesity is a global epidemic, with over 2.5 billion adults being classified as overweight and 890 million of these classified as obese.
- Trial name
- APPETITE (NCT07104461)
- Testing
- Oat porridge, Whey protein isolate, Potato protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Insulin Resistance
Changes in Insulin Resistance in Healthy Volunteers on STRIBILD® Medication
Changes in insulin resistance in healthy volunteers with normal body weight (BMI 18-25) after 14 days of STRIBILD®-, Truvada®/Kaletra® or Truvada®/Prezista®/Norvir® intake, measured by hyperinsulinemic euglycemic clamp.
- Trial name
- NCT02203461
- Testing
- Tenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistat, Tenofovir disaproxil fumarate/emtricitabine + Lopinavir/ritonavir, Tenofovir disaproxil fumarate/emtricitabine + ritonavir-boosted darunavir
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Insulin Sensitivity
Influence of Brain Insulin Sensitivity on Peripheral Insulin Sensitivity
The researchers will investigate if brain insulin action influences peripheral insulin sensitivity in healthy humans.
- Trial name
- NCT01847456
- Testing
- human insulin as nasal spray
- Where
- Germany
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Insulin Resistance, Microvascular Disease
The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in healthy subjects.
- Trial name
- NCT01122641
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Impaired Glucose Tolerance
Cognitive Effects of Aerobic Exercise for IGT Adults
The specific aims for the study will be to determine if aerobic exercise enhances cognition for older adults who are at risk for developing type II diabetes mellitus (T2DM), and to evaluate whether change in insulin sensitivity…
- Trial name
- NCT00220441
- Testing
- Aerobic exercise
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
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