Clinical trials: Intensity Care
Mental Disorder
Acute-REMOTION: REMOTION in Acute Psychiatric Care
This study aims to examine REMOTION, an internet-based intervention aimed at reducing symptom severity and improving emotion regulation in an acute psychiatric inpatient care setting.
- Trial name
- Acute-REMOTION (NCT04990674)
- Testing
- REMOTION, TAU
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Bern
Breast Cancer, Stage III Breast Cancer
TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients
This research is being done to assess whether an exercise intervention with protein intake support vs a health education and support program will make it easier for women age 65 or older who are receiving chemotherapy for breast…
- Conditions
- Breast Cancer, Stage III Breast Cancer, Breast Cancer Female, Stage I Breast Cancer
- Trial name
- THRIVE-65 (NCT05535192)
- Testing
- THRIVE, Health Education Support Program
- Where
- 4 sites in United States
- Volunteers
- 270 people
- Sponsor
- Dana-Farber Cancer Institute
Shock, Aortic Valve Disease
Non-invasive Prediction of Fluid and Noradrenaline Responsiveness Using the Carotid Wave Intensity.
The goal of this observational study is to study a new method to compute ventricular-arterial coupling (VAC) in adult intensive care patients after cardiac surgery.
- Conditions
- Shock, Aortic Valve Disease, Coronary Artery Disease, Mitral Valve Disease
- Trial name
- VACC (NCT06197321)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Graft Versus Host Disease
Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell Transplant
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer.
- Trial name
- NCT01754389
- Testing
- Tacrolimus, Methotrexate, Bortezomib
- Where
- 4 sites in United States
- Volunteers
- 138 people
- Sponsor
- Dana-Farber Cancer Institute
Schizophrenia
Effect of Genotyping for CYP450 Polymorphisms Versus Intense Clinical Monitoring on Antipsychotic Drug Treatment
The purpose of this study is to determine whether genotyping for CYP2D6 and 2C19 polymorphisms or intense clinical monitoring of treatment and adverse effects improves the antipsychotic treatment in patients with schizophrenia.
- Trial name
- NCT00707382
- Testing
- (1) Genotyping for CYP4502D6 and 2C19 polymorphisms, (2) Intense clinical monitoring, (3) Control
- Where
- Denmark
- Volunteers
- 311 people
- Sponsor
- Gesche Jurgens
Perioperative Care
The Impact of Preoperative Statin Therapy and and Its Intensity on Postoperative and Mortality and Morbidity
Statins are among the most widely prescribed drugs worldwide, and their benefits in cardiovascular risk reduction are well established.
- Trial name
- STIMM (NCT07575737)
- Where
- 2 sites in Sweden
- Volunteers
- 70,000 people
- Sponsor
- Karolinska Institutet
Sepsis Syndrome, Sepsis
Mitochondrial DNA as a Biomarker of Sepsis Severity
Mitochondria are organelles (a specialized subunit of a cell) responsible for providing cells with energy. For reasons not yet understood, mitochondria will release their DNA into blood in response to cellular injury or cell…
- Conditions
- Sepsis Syndrome, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- MBOSS (NCT03077672)
- Where
- 2 sites in United States
- Volunteers
- 1,304 people
- Sponsor
- Weill Medical College of Cornell University
Sickle Cell Disease
Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell Disease
Although the survival of children with sickle cell disease (SCD) has dramatically improved over the last decades in the US and Europe, mortality remains high in adults.
- Trial name
- DREPA-RIC (NCT04046705)
- Testing
- Allogeneic matched related haematopoietic stem cell transplantation, Standard arm
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obsessive Compulsive Disorder (OCD)
Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT
This study is conducted to explore the efficacy and cost-effectiveness of stepped-care internet-based cognitive behavior therapy (sc-ICBT) with reduced support compared to cognitive-behavioral group therapy(CBGT), to identify the…
- Trial name
- NCT06659094
- Testing
- stepped-care Internet-based cognitive behavioral therapy(SC-ICBT), Cognitive Behavioral Group Therapy (CBGT), conventional medical treatment (TAU)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Shanghai Mental Health Center
Pericarditis
Effects of Pulmonary Rehabilitation Versus Standard Care in Patients With Pericarditis
Pericarditis is associated with symptoms such as chest pain, dyspnea, fatigue, cough, and anxiety, which can significantly impair functional capacity and quality of life.
- Trial name
- NCT07716696
- Testing
- Pulmonary Rehabilitation, Standard Care
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Nervous System Diseases
Cost/Utility Ratio in the Management of Patients With Acquired Severe Brain Injury
The aim of this study was to compare the cost/utility ratio of a management model of integrated, graded, intensive rehabilitation (GIR) versus usual care (UC) for patients with acquired Severe Brain Injury (SBI).
- Trial name
- NCT01743261
- Testing
- multidisciplinary intervention, usual care
- Where
- Italy
- Volunteers
- 249 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome
A Randomized Study to Investigate the Effect of Intravenous Imatinib on the Amount of Oxygen in the Lungs and Blood of Adults With COVID-19 Needing Mechanical Ventilation and Supportive Care.
The COVID-19 pandemic has led to an increase in the number of patients admitted to intensive care units (ICU) with acute respiratory distress syndrome (ARDS).
- Conditions
- Acute Respiratory Distress Syndrome, COVID-19 Acute Respiratory Distress Syndrome, Covid19, ARDS
- Trial name
- IMPRESS COVID (NCT04953052)
- Testing
- Imatinib Mesylate
- Where
- 8 sites in India
- Sponsor
- Exvastat Ltd.
Asthma, Eosinophilic Asthma
Intense Airway Eosinophilia in Asthma
In asthma, the type and importance of the inflammatory response in the airways has allows identification of different phenotypes.
- Trial name
- NCT03696914
- Where
- Canada
- Volunteers
- 918 people
- Sponsor
- Laval University
Cerebral Vascular Accident
Inpatient Rehabilitation and Post-Discharge Outcomes With High Intensity Gait Training (HIGT) of Patients With Stroke
Stroke is a major cause of disability, with 2-3% of Americans reporting stroke related impairments (Tsao 2022). Following stroke, over half of Medicare patients are discharged to post-acute care facilities or receive home-based…
- Trial name
- HIGT (NCT05650606)
- Testing
- High Intensity Gait Training, Conventional Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sunnyview Rehabilitation Hospital
Neonatal SEPSIS
Severity Index of Neonatal Septicemia Using Score for Neonatal Acute Physiology (SNAP) II
To determine the effect of Score for Neonatal Acute Physiology II as a Predictor of Mortality and Organ Dysfunction in Neonates with Septicemia in the Neonatal Intensive Care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at…
- Trial name
- SNAP (NCT03746743)
- Testing
- score for neonatal sepsis
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmed Mahmoud Ali Ali Youssef
Intensive Care Unit Delirium, Encephalopathy
Automating Delirium Severity in the ICU
The goal of this observational study is to develop a passive digital marker (PDM) for delirium severity and examine its performance in comparison to validated delirium severity tools in ICU patients >50 years of age.
- Conditions
- Intensive Care Unit Delirium, Encephalopathy, Delirium
- Trial name
- ADS-ICU (NCT06172491)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
COVID, Acute Respiratory Distress Syndrome
Impact of Angiotensin II Receptor Blockers Treatment in Patients With COVID 19 (COVID-ARA2)
The actual pandemic infection related to SARS-CoV2 results in viral pneumonitis (COVID-19), that may, in the more severe cases, lead the patients to the intensive care unit (ICU).
- Trial name
- COVID-ARA2 (NCT04337190)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Pregnancy, Postpartum
HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children
Regular exercise during pregnancy and postpartum leads to health benefits for mother and child. Inactivity during pregnancy and after delivery is now treated as risky behavior.
- Conditions
- Pregnancy, Postpartum, Childbirth, Health Status
- Trial name
- HIIT MAMA (NCT05009433)
- Testing
- High intensity interval training program for pregnant women, Moderate intensity continuous training program for pregnant women, Standard obstetric care with extended education on healthy lifestyle
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Depression, Depression in Old Age
Technology-enabled Task-sharing for Depression in Primary Care
This study will explore and test the feasibility, acceptability, usability, and preliminary effectiveness of a technology-enabled intervention for depression using task-sharing in primary care.
- Trial name
- NCT04055155
- Where
- United States
- Sponsor
- University of Washington
Critically Ill Patients
Disease Severity, Mortality Risk, and Muscle Function in Intensive Care Unit Patients
Intensive Care Units are specialized, technologically advanced hospital units that provide continuous monitoring and care from multiple healthcare disciplines for patients who are critically ill and face a high risk of death or…
- Trial name
- NCT07124442
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istinye University