Clinical trials: Intensive Care (ICU) Myopathy
Brain Injuries, Dementia
ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit
Intensive care unit (ICU) hospitalization saves lives but often does so at a high personal cost to ICU survivors who frequently experience significant cognitive impairment and an array of physical and functional disabilities that…
- Conditions
- Brain Injuries, Dementia, Myopathies, Muscle Disorders
- Trial name
- ACT-ICU (NCT01270269)
- Testing
- Behavioral: Physical and functional rehabilitation, Behavioral: Cognitive, physical, & functional rehabilitation
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Vanderbilt University
Myopathy, Neuropathy
Electro-Neuro-Muscular Stimulation in ICU
We will examine whether the application of electro-neuro-muscular stimulation (ENMS) in critical care patients, can decrease the impact or severity of the critical illness myopathy (CIM) or neuropathy.
- Trial name
- NCT02011282
- Testing
- Patients will receive daily sessions of electro-neuro-stimulation in the quadriceps muscle for 10 days
- Where
- Greece
- Volunteers
- 25 people
- Sponsor
- University of Thessaly
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Post Intensive Care Unit Syndrome, Critical Illness
Improving Recovery After Critical Illness
Rationale: Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Critical Illness, Malnutrition, Muscle Weakness
- Trial name
- IMPROVE (NCT05182086)
- Testing
- Group physical therapy and dietary improvements
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Frisius Medisch Centrum
Diaphragm Issues, Mechanical Ventilation Complication
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.
- Conditions
- Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
- Trial name
- DAM (NCT05211661)
- Testing
- Respiratory Muscle Testing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Metabolomics, Critical Care
Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma
In this mono-center pilot trial, polytrauma patients admitted to intensive care will be included. Investigators are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular…
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE II (NCT03819959)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Technical University of Munich
Sarcopenia, Critical Illness
Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.
This is a prospective, observational study at the ICU of Hospital Mútua de Terrassa, running from May to December 2025. The primary goal is to determine the prevalence of sarcopenia in adult patients requiring more than 48 hours…
- Conditions
- Sarcopenia, Critical Illness, Intensive Care (ICU) Myopathy, Body Composition Measurement
- Trial name
- SARC-ICU (NCT07303335)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Mutua de Terrassa
Intensive Care Unit Acquired Weakness, Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
Functional Assessment in Critically Ill Patients
This longitudinal, prospective observational study aims to evaluate functional status in critically ill adult patients in the Intensive Care Unit using the Chelsea Critical Care Physical Assessment Tool (CPAx).
- Trial name
- NCT07191743
- Where
- Brazil
- Volunteers
- 186 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Respiratory Failure
Respiratory Care in Intensive Care Unit for Neuromuscular Patients
Retrospective multicentric observational study exploring the population of adult neuromuscular patients presenting a respiratory distress requiring their admission in an Intensive Care Unit (ICU) for ventilatory support.
- Trial name
- NCT02936908
- Testing
- Ventilatory support
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Muscle Weakness
Muscle Function and Muscle Ultrasound in ICU
The objective of intensive care therapists is to be able to detect as early as possible the muscle weakness acquired in intensive care, in order to implement curative strategies such as adapted nutrition and early rehabilitation.
- Trial name
- DYNAMIQUE (NCT04696497)
- Testing
- Ultrasound, Dynamometric muscular assessment, Manual muscular Assessment (MRC-SS)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Muscle Weakness, Critical Illness
Critical Illness Neuromuscular Abnormalities in Neurocritical Care Patients
The aim of this research is to investigate critical illness neuromuscular abnormalities in neurocritical care patients.
- Trial name
- NCT00893633
- Where
- Russia
- Volunteers
- 135 people
- Sponsor
- Clinical Institute of the Brain, Russia
Intensive Care (ICU) Myopathy, Functional Disturbance
Intra and Inter Reliability and Validity of the Turkish Version of Ottowa Sitting Scale in Intensive Care Unit Survivors
Introduction-Objective: Balance evaluation is one of the most important components of physical examination. Studies on equilibrium assessment in different research groups; It includes measurements that assess the seating balance…
- Trial name
- NCT03936920
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Izmir Katip Celebi University
ICU Survivor, Muscle Weakness
Post Intensive Care Optimization Through Lifestyle Intervention
The quality of the intensive care unit (ICU) has been steadily improving over the years. Although improvements in the acute treatment of critically ill patients have been made, a large number of ICU survivors suffer from severe…
- Trial name
- PICOLI (NCT06771895)
- Testing
- Combined exercise and nutritional intervention
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Maastricht University Medical Center
Polyneuropathy
Neuromuscular Electrical Stimulation in the Critically Ill
Neuromuscular stimulation (NMES) has been used for several years in the rehabilitation of COPD (chronic obstructive pulmonary disease) patients (among others) to improve their resistance to efforts in everyday life.
- Trial name
- NCT02566941
- Testing
- Gymna Belgium, DUO 400 (Neuromuscular electrical stimulation)
- Where
- Belgium
- Sponsor
- Brugmann University Hospital
Muscle Weakness, Critical Illness
Translation and Validation of the Intensive Care Unit Mobility Scale (IMS)
Intensive care unit acquired weakness (ICUAW) is a common issue in critically ill patients. Early mobilization can reduce the occurrence of ICUAW. This requires a standardized procedure based on validated scales.
- Conditions
- Muscle Weakness, Critical Illness, Mechanical Ventilation Complication, Early Mobilization
- Trial name
- TAVIMS (NCT05591950)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Muscle Weakness, Renal Failure
Predictors of Respiratory Failure Following Extubation in the SICU
Respiratory failure following extubation causes significant morbidity and increases mortality in teh surgical intensive care unit (SICU). However the causes of respiratory failure following extubation remain poorly understood.
- Conditions
- Muscle Weakness, Renal Failure, Respiratory Comorbidities
- Trial name
- NCT01967056
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Critical Illness, Muscle Weakness
Progressive Mobility Program and Technology to Improve the Level of Physical Activity and Functionality of ICU Patients
The purpose of this study is to verify if a protocol of early and progressive mobility which includes the use of technology is able to increase the level of physical activity and improve functionality and respiratory and muscular…
- Trial name
- NCT02889146
- Testing
- Conventional Physical Therapy, Early and progressive mobilization program, Respiratory therapy
- Where
- Brazil
- Volunteers
- 98 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Kidney Injury, Intra-Abdominal Hypertension
Cumulative Intra-Abdominal Pressure Burden and Acute Kidney Injury After Emergency Abdominal Surgery
The goal of this observational study is to learn whether increased pressure inside the abdomen over time is associated with acute kidney injury in adults receiving intensive care after emergency abdominal surgery.
- Trial name
- IAP-AKI (NCT07891026)
- Testing
- Serial Intra-Abdominal Pressure Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Ugur Duman
Muscle Weakness
Safety Evaluation of Functional Electrical Stimulation (FES) Cycling in Intensive Care Unit Patients
Intensive care unit acquired muscle weakness (ICUAW), is a common disease which influence rehabilitation, extend mechanical ventilation and length of stay in intensive care unit, and affect quality of life at hospital discharge.
- Trial name
- FES Cycling (NCT03526211)
- Testing
- FES cycling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Intensive Care Unit, Respiratory Insufficiency
Low Creatinine Level and Respiratory Failure
Low creatinine levels may be a sign of muscle atrophy or weakness, and therefore predictive for respiratory insufficiency in the Intensive care unit (ICU) patients.
- Conditions
- Intensive Care Unit, Respiratory Insufficiency, Muscle Weakness
- Trial name
- NCT04368325
- Testing
- Serum creatinine levels
- Where
- Croatia
- Volunteers
- 107 people
- Sponsor
- Osijek University Hospital