Clinical trials: Intensive Care Unit Acquired Weakness
Intensive Care (ICU) Myopathy
Biomechanical Properties in Intensive Care Unit (ICU) Survivors 12-month After Discharge
Intensive care unit (ICU) admission is associated with muscle weakness and ICU survivors report persevering limitation of physical capacity for years after discharge.
- Trial name
- NCT01364714
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Critical Illness, ICU Acquired Weakness
Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial)
Due to medical advances and quality of care, mortality in adult intensive care units (ICUs) has decreased significantly in recent years, leading to a significant increase in the number of patients with high rehabilitation needs…
- Conditions
- Critical Illness, ICU Acquired Weakness, Malnutrition
- Trial name
- NutriPhyT (NCT05865314)
- Testing
- Optimisation of nutrition therapy coupled with early mobilisation, Standard care
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- HEIDEGGER CP
Mechanical Ventilation Complication, Pediatric ALL
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
Critically ill children treated with invasive mechanical ventilation (iMV) in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.
- Conditions
- Mechanical Ventilation Complication, Pediatric ALL, Intensive Care Unit Acquired Weakness
- Trial name
- NCT04589910
- Testing
- diaphragm thickness and thickening fraction
- Where
- Netherlands
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Critical Illness, PICS
ICU Follow-up After Prolonged Intensive Care Stay
Treatment in the intensive care unit (ICU) for more than five days often leads to chronic physical, cognitive and psychological complaints, such as post-traumatic stress disorders, muscle weakness, depression, anxiety and…
- Conditions
- Critical Illness, PICS, Post Intensive Care Syndrome
- Trial name
- PINA (NCT04186468)
- Testing
- ICU follow-up clinic
- Where
- 3 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Otto-von-Guericke University Magdeburg
Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness
Intensive Care Unit Recovery
Survival rates of patients with critical illness have increased due to improved facilities and treatment methods in the intensive care unit (ICU).
- Conditions
- Post Intensive Care Unit Syndrome, Intensive Care Unit Acquired Weakness, Critical Illness
- Trial name
- ICU-RE (NCT04154995)
- Testing
- Venipuncture, Ultrasound Quadriceps Muscles
- Where
- Netherlands
- Volunteers
- 81 people
- Sponsor
- Frisius Medisch Centrum
Sepsis, Critical Illness
MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients
The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength.
- Conditions
- Sepsis, Critical Illness, ICU-acquired Muscle Weakness, ICU-acquired Weakness
- Trial name
- ICUAW (NCT07362862)
- Testing
- Electrical Muscle Stimulation System
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Health Discovery Labs
ICU Acquired Weakness
Diagnosing Intensive Care Unit (ICU) Acquired Weakness
The goal of this study is to develop a non-invasive test to diagnose intensive care unit (ICU) acquired weakness that can be administered to both responsive and non-responsive patients.
- Trial name
- NCT04166630
- Testing
- Clinical Electrical Stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Post-Intensive Care Syndrome, ICU Acquired Weakness
Hand and Arm Rehabilitation Using VR
Patients admitted to the ICU due to critical illness often experience physical, mental, cognitive, or social issues. Research indicates that inadequate physical recovery is associated with lower handgrip strength, and hand…
- Trial name
- HANDQUEST (NCT06373341)
- Testing
- VR training for arm and hand rehabilitation
- Where
- Netherlands
- Volunteers
- 108 people
- Sponsor
- Frisius Medisch Centrum
Virtual Reality, Intensive Care Unit Acquired Weakness
The Effects of Virtual Reality in Intensive Care Patients
Weakness of respiratory muscles delays weaning from the ventilator, prolongs hospital stay and increases treatment costs. Conventional treatments for respiratory muscles reverse these negative effects.
- Trial name
- NCT06442254
- Testing
- Virtual Reality
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istinye University
Critical Illness
Physical Therapist Inter-Rater Reliability in Neuro-Muscle Ultrasound in Critically Ill Patients
The goal of this observational study is to evaluate the feasibility and inter-rater reliability of muscle and peripheral nerve ultrasound for the early detection of ICU-acquired weakness (ICU-AW) in critically ill patients.
- Trial name
- NMusICU-R (NCT07032870)
- Where
- Chile
- Volunteers
- 37 people
- Sponsor
- University of Chile
Respiratory Failure, Sepsis
Electric Acupuncture for ICU-acquired Weakness in Mechanical Ventilation Patients
Intensive care unit acquired weakness (ICU-AW) is common and dramatically affect recovery. The purpose of this study is to determine whether electric acupuncture therapy is effective in the treatment of ICU-AW especially in the…
- Conditions
- Respiratory Failure, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- EA-ICUAW (NCT02204215)
- Testing
- electric acupuncture, conservative
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Jiangsu Province Hospital of Traditional Chinese Medicine
ICU Acquired Weakness
Evaluation of FDY-5301 in Major Trauma Patients in ICU
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics (PK) of FDY-5301 compared to placebo in major trauma ICU patients at risk of intensive care unit acquired weakness (ICUAW)
- Trial name
- NCT04430283
- Testing
- FDY-5301
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Faraday Pharmaceuticals, Inc.
COVID-19, Critical Illness
REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19
Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.
- Conditions
- COVID-19, Critical Illness, ICU Acquired Weakness, PICS
- Trial name
- REMM-HIIT-CoV (NCT05218083)
- Testing
- REmotely monitored, Mobile health supported Multidomain Rehabilitation Program with High Intensity Interval Training (REMM-HIIT)
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Liver Cirrhoses, Liver Failure
Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care Unit
Critically-ill patients with liver disease are at high risk of developing sarcopenia and intensive care unit (ICU)-acquired weakness, which are associated with mortality and other poor outcomes.
- Conditions
- Liver Cirrhoses, Liver Failure, ICU Acquired Weakness
- Trial name
- NCT04160039
- Testing
- Cycle ergometry
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Medical College of Wisconsin
Polyneuropathy
Neuromuscular Electrical Stimulation in the Critically Ill
Neuromuscular stimulation (NMES) has been used for several years in the rehabilitation of COPD (chronic obstructive pulmonary disease) patients (among others) to improve their resistance to efforts in everyday life.
- Trial name
- NCT02566941
- Testing
- Gymna Belgium, DUO 400 (Neuromuscular electrical stimulation)
- Where
- Belgium
- Sponsor
- Brugmann University Hospital
Muscle Weakness, Critical Illness
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
Elderly patients who experience a prolonged ICU stay are at high risk for developing post intensive care unit syndrome (PICS), a serious medical condition manifested by loss of muscle mass, weakness, malnutrition and…
- Conditions
- Muscle Weakness, Critical Illness, Sarcopenia
- Trial name
- ExPrEs (NCT02509520)
- Testing
- MPR and High Protein Supplement (HPRO) and Neuromuscular Electric Stimulation (NMES)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium
Efficacy of the "Start to Move" Protocol on Functionality, Delirium and Acquired Weakness in ICU
Background: ICU hospitalization is associated with loss of strength, functionality and delirium. The "Start to Move protocol" demonstrated efficacy in improving and minimizing such effects.
- Conditions
- Intensive Care Unit Acquired Weakness, Intensive Care Unit Delirium, Intensive Care Neuropathy, Intensive Care Unit Syndrome
- Trial name
- STM (NCT05053724)
- Testing
- Star to move Protocol
- Where
- Chile
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Hospital Felix Bulnes
Critical Illness
The Role of NEMS for Post ICU Rehabilitation
The purpose of this study is to investigate the role of NEMS as a rehabilitation tool for muscle weakness following critical illness.
- Trial name
- NCT01717833
- Testing
- NEMS
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Athens
Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome
Supporting the Recovery Needs of Patients Following Intensive Care
Recovery for intensive care survivors is limited by ongoing problems with walking, strength, fatigue, mental distress and cognitive morbidity known as 'Post Intensive Care Syndrome'.
- Conditions
- Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome, ICU Acquired Weakness, Intensive Care Unit Syndrome
- Trial name
- NCT05044221
- Testing
- Former ICU patient and caregiver workshops, Health care professional workshops
- Where
- 2 sites in Australia
- Volunteers
- 40 people
- Sponsor
- University of Melbourne
ICU Acquired Weakness (ICUAW)
Feasibility of a Digital Rehabilitation Platform in Patients After ICU Discharge
This study aims to evaluate the feasibility, usability, and clinical effectiveness of a digital rehabilitation platform in adult patients discharged from the intensive care unit (ICU).
- Trial name
- NCT07489092
- Testing
- Digital Rehabilitation Group
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Asan Medical Center