Clinical trials: Interventions
Child Development
Early Literacy Promotion Intervention
This study is testing the effects of early literacy promotion compared to standard literacy promotion at The Children's Hospital of Philadelphia.
- Trial name
- ELPI (NCT02713659)
- Testing
- Early Literacy Promotion, Standard Literacy Promotion
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Cancer, Congestive Heart Failure (CHF)
Outlook Quality of Life Intervention Study
The purpose of this study is to determine whether discussions of life story, forgiveness, and future goals improve quality of life for patients with serious illness.
- Conditions
- Cancer, Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), End Stage Renal Disease (ESRD)
- Trial name
- NCT01044290
- Testing
- Life Completion, Attention Control
- Where
- United States
- Volunteers
- 221 people
- Sponsor
- VA Office of Research and Development
Tinnitus
A CBT-based Internet Intervention for Adults With Tinnitus in the United Kingdom
The purpose of this study is to determine the feasibility and effectiveness of a CBT-based internet intervention for adults with tinnitus in the United Kingdom
- Trial name
- NCT02370810
- Testing
- CBT-based internet-intervention for tinnitus
- Where
- United Kingdom
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Depression, Anxiety
Community Intervention to Improve Depressive Symptoms Among Older Adults (VIDACTIVA)
The goal of this pilot trial is to test how feasible is to conduct a large clinical trial that evaluate both implementation and effectiveness outcomes of a community-based interventions for older adults with depression in…
- Trial name
- VIDACTIVA1 (NCT06065020)
- Testing
- VIDACTIVA sessions, Standard Care
- Where
- Peru
- Volunteers
- 72 people
- Sponsor
- Universidad de San Martín de Porres
Suicide
Suicide Prevention Intervention for Vulnerable Emerging Adult Sexual Minorities
Emerging adult sexual minorities (EASM) are vulnerable to stressors that increase risk for suicidal ideation and behaviors. The investigators will examine a mobile application that leverages skills coaching and peer mentoring to…
- Trial name
- NCT05018143
- Testing
- STARS, Control condition
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Pennsylvania
HIV
Online Social Networking for HIV Prevention
In this randomized controlled trial, we will identify social networks on Facebook, an randomly assign each network to control or intervention status.
- Trial name
- NCT00725959
- Testing
- Online social networking HIV prevention
- Volunteers
- 1,578 people, healthy volunteers welcome
- Sponsor
- Colorado School of Public Health
Covid19
Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE
This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients
- Trial name
- ACTIV-4A (NCT04505774)
- Testing
- theraputic heparin, prophylactic heparin, P2Y12
- Where
- 101 sites in United States, Brazil and 2 more
- Volunteers
- 3,591 people
- Sponsor
- Matthew Neal MD
COVID-19
Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization
The purpose of this study is to determine if temporary androgen suppression improves the clinical outcomes of Veterans who are hospitalized to an acute care ward due to COVID-19.
- Trial name
- HITCH (NCT04397718)
- Testing
- Degarelix, Saline
- Where
- 14 sites in United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Monoterpene Exposure During a Forest Bathing Intervention
Do Terpenes Play a Role in the Stress-reducing Effects of a Forest Bathing Intervention?
This pilot study evaluates the role terpenes play in the stress-reducing effects of a forest bathing intervention. Participants will participate in two interventions in random order: 1) terpene exposure and 2) no terpene exposure.
- Trial name
- NCT05316597
- Testing
- Forest bathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Cardiovascular Disease Other, Physical Activity
Young Adult Congenital Heart Disease Physical Activity Lifestyle Study (YACHD-PALS)
This study will adapt a physical activity lifestyle intervention to emerging adult congenital heart disease (CHD) survivors with the primary goal of increasing physical activity levels. The study will be split into 2 phases.
- Trial name
- YACHD-PALS (NCT04135859)
- Testing
- Physical Activity Lifestyle Intervention, Physical Activity Monitoring
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Jamie Jackson
RSV Immunization, Healthy Volunteer
Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of Life
The purpose of this study was to determine the efficacy and safety of a single intramuscular (IM) dose of nirsevimab, compared to no intervention, for the prevention of hospitalizations due to lower respiratory tract infection…
- Trial name
- NCT05437510
- Testing
- Nirsevimab
- Where
- 240 sites in France, Germany and 1 more
- Volunteers
- 8,057 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Traumatic Brain Injury
Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT)
The Citicoline Brain Injury Treatment (COBRIT) is a randomized, double-blind, placebo controlled, multi-center trial of the effects of 90 days of citicoline on functional outcome in patients with complicated mild, moderate and…
- Trial name
- COBRIT (NCT00545662)
- Testing
- citicoline
- Where
- 8 sites in United States
- Volunteers
- 1,213 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Risk Behavior, HIV/AIDS
Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use Drugs
This study will evaluate the efficacy and cost-effectiveness of CHRP-BB - an integrated bio-behavioral approach that incorporates the use of PrEP - with an evidence-based behavioral approach aimed at enhancing PrEP adherence and…
- Conditions
- Risk Behavior, HIV/AIDS, Medication Adherence, Substance Abuse
- Trial name
- CHRP-BB (NCT03282890)
- Testing
- CHRP-BB
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- University of Connecticut
Chronic Pain, Low Back Pain
Meditation-CBT for Opioid-treated Chronic Low Back Pain
Chronic low back pain (CLBP) is one of the most common, costly and disabling conditions. It is often refractory to treatment, with patients requiring long-term opioid therapy.
- Trial name
- NCT01775995
- Testing
- Meditation-CBT Intervention + Usual Care, Usual Care Alone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease
(A Novel Pharmacologic Regime for Elective Percutaneous Coronary Intervention)
The hypothesis: Low dose intracoronary unfractionated heparin is as effective and safe as standard dose intravenous unfractionated heparin on patients with elective percutaneous coronary intervention.
- Trial name
- REDUCED (NCT01031095)
- Testing
- coronary intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Bursa Postgraduate Hospital
Cardiovascular Risk Factor
Random Assignment of Intervention Messages for Developing Personalized Decision Rules to Promote Physical Activity
Our goal is to develop personalized decision rules for selecting the frequency, timing, and content of messages to promote physical activity.
- Trial name
- RandomAIM (NCT03907683)
- Testing
- Short Message with Text and Optional Image
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Penn State University
Persian Gulf Syndrome
Mindfulness-Based Stress Reduction for Gulf War Syndrome
This pilot study is a two arm randomized, controlled clinical trial that evaluated whether a standardized Mindfulness-Based Stress Reduction (MBSR) intervention reduces symptoms associated with Gulf War Syndrome (GWS) more…
- Trial name
- NCT01267045
- Testing
- Mindfulness-based stress reduction
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- US Department of Veterans Affairs
Diabetes Mellitus, Type 2
A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.
- Trial name
- THEMIS (NCT01991795)
- Testing
- Ticagrelor 60 mg
- Where
- 1,237 sites in United States, Argentina and 41 more
- Volunteers
- 19,271 people
- Sponsor
- AstraZeneca
Overweight and Obesity
SMART 2.0: Social Mobile Approaches to Reducing weighT in Young Adults
The SMART 2.0 study is a 24-month trial designed to evaluate the impact of the intervention with technology and personal health coaching or with technology alone on objectively measured weight among overweight young adults in a…
- Trial name
- SMART 2 (NCT03907462)
- Testing
- SMART 2.0
- Where
- United States
- Volunteers
- 638 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pancreatitis, Diabetes
Sitagliptin Therapy to Improve Outcomes After Islet Autotransplant
The purpose of the study is to test the effects of sitagliptin on the need for insulin (the hormone that lowers blood sugars) by patients who receive a pancreatectomy and islet autotransplant for chronic pancreatitis.
- Trial name
- NCT01186562
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Minnesota
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