Clinical trials: Interventions
Depressive Symptoms, Anxiety
Living Well: A Digital ACT Intervention
Depression and anxiety are frequently comorbid and share mechanisms contributing to dysfunction. Transdiagnostic approaches, such as Acceptance and Commitment Therapy, streamline intervention and allow a broader population to…
- Conditions
- Depressive Symptoms, Anxiety, Emotional Disorders
- Trial name
- NCT04787809
- Testing
- Living Well
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Texas at Tyler
Primary Malignant Neoplasm of Lung, Primary Malignant Neoplasm of Gastrointestinal Tract
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Consecutive Cohort Study
To assess the feasibility of a creative writing intervention in an advanced cancer population. Given it is a relatively simple intervention delivered by a non-clinician, the investigators are interested in better understanding…
- Trial name
- NCT02575898
- Testing
- First Session, Second Session, Third through Sixth Sessions
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Breast Neoplasm Female
Digital Delivery of Information About Genetic Testing for Breast Cancer
BRCA-DIRECT is a pragmatic, randomised, non-inferiority evaluation that aims to evaluate whether digital delivery of pre-test information for BRCA-testing in breast cancer patients is non-inferior to current standard practice of…
- Trial name
- BRCA-DIRECT (NCT04842799)
- Testing
- Digital Delivery of Pre-Genetic Testing Information via the BRCA-DIRECT Platform, Digital Delivery of Genetic Test Results via the BRCA-DIRECT Platform
- Where
- 5 sites in United Kingdom
- Volunteers
- 1,140 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Spinal Cord Injuries
Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury
The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in…
- Trial name
- NCT05317832
- Testing
- WI program, WI Program Reminder, JITAI Goal Setting
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Temple University
Postpartum Depression, Small for Gestational Age at Delivery
Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention
In the proposed study the investigators will develop an early prenatal preventive intervention targeting anxiety and conduct a randomized controlled trial in Pakistan to test its efficacy in reducing generalized anxiety disorder…
- Conditions
- Postpartum Depression, Small for Gestational Age at Delivery, Preterm Birth, Anxiety
- Trial name
- HMHB (NCT03880032)
- Testing
- Cognitive Behavioral Therapy Intervention for Anxiety
- Where
- Pakistan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cardiometabolic Conditions, Hypertension (HTN)
To Test the Effectiveness and Implementation Approach of a 3-month PILI Pasifika Program Lifestyle Program With Components of Social Determinants of Health Activities in Real-world Settings (Clinical and Non-clinical Settings) Across 3 Years
In this study, the investigators are conducting a Type 3 hybrid effectiveness-implementation trial to evaluate the implementation of the Community Health Workers (CHW)-delivered PILI Pasifika Program (PPP) across 3 regions, the…
- Conditions
- Cardiometabolic Conditions, Hypertension (HTN), Dyslipidemia, Pre-diabetes
- Trial name
- NCT07387393
- Testing
- PILI (Partnership for Improving Lifestyle Intervention) Pasifika Program
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Hawaii
Oncology
Recommendations for a Radiotherapy Comfort Intervention Package Radiotherapy
A consensus study using nominal group technique is planned to develop recommendations for a comfort intervention package for radiotherapy with patients and therapeutic radiographers.
- Trial name
- NCT05149521
- Testing
- None - this is a consensus group study to develop an intervention
- Volunteers
- 12 people
- Sponsor
- University of the West of England
Tinnitus, Acute
In This Study, we Are Testing Whether Combining Two Interventions, in the Early Stages of Tinnitus, is More Effective in Quieting Tinnitus Than Using One Treatment Alone in the Later Stages of Tinnitus
Tinnitus affects one in seven adults long-term Once present persistently for 4 weeks, tinnitus does not usually disappear People generally become less aware of, and less affected by, their tinnitus over time Only one in six…
- Trial name
- ATtDCS (NCT07128004)
- Testing
- tDCS, sound therapy
- Volunteers
- 80 people
- Sponsor
- Newcastle University
Pollution; Exposure, Hypertension
Solar Lighting to Reduce Indoor Air Pollution in Rural Uganda
This study evaluates the impact of a solar lighting system on kerosene lamp use, levels of indoor air pollution, and health in women living in rural Uganda.
- Conditions
- Pollution; Exposure, Hypertension, Pollution Related Respiratory Disorder
- Trial name
- NCT03351504
- Testing
- Solar lighting system
- Where
- 2 sites in United States, Uganda
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Early Child Development and Growth
The Pakistan Early Childhood Development Scale Up Trial
The purpose of this study is to evaluate whether the integration of an early child 'stimulation and care for development' intervention, either alone or in combination with an 'enhanced care for nutrition' intervention, delivered…
- Trial name
- PEDS (NCT00715936)
- Testing
- Control, ECD, Enhanced Nutrition
- Where
- Pakistan
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Spasm Artery
Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention
Radial artery is the recommended route for percutaneous coronary intervention for it significantly reduces net adverse clinical events compared to the femoral approach.
- Trial name
- NCT04538534
- Testing
- Nicardipine
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- Pr. Semir Nouira
Neoplasm
Evaluating Biobanking Educational Tools
The purpose of this study is to evaluate English and Spanish language educational materials that inform the community about a type of cancer research that involves the collection, storage, and processing of biospecimens.
- Trial name
- NCT01672944
- Testing
- TBCCN-developed educational materials, NCI-developed educational materials
- Where
- United States
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Care Transitions
Improving Care Transitions for Medicaid Insured Individuals With Co-occurring Serious Mental Illness
This study aims to evaluate the THRIVE clinical pathway at HUP, focusing on supporting Medicaid-insured individuals, including those with serious mental illness, following hospitalization.
- Trial name
- THRIVE-SMI (NCT06203509)
- Testing
- Thrive Intervention
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Stable Angina, Non ST Segment Elevation Myocardial Infarction
INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
The current study sought to evaluate the clinical relevance of iFR-guided strategy in real world clinical practice using unrestricted study population from stable angina to acute coronary syndrome including acute ST-segment…
- Conditions
- Stable Angina, Non ST Segment Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction, Silent Myocardial Ischemia
- Trial name
- INTERPRET (NCT03338309)
- Testing
- Instantaneous wave-free ratio measurement
- Where
- 4 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Health Care Transition, Care Coordination
Improving Health Care Transition for Youth With Special Needs
Special opportunities exist in vulnerable populations with chronic conditions to better understand what life course factors can facilitate attainment of optimal health and development.
- Trial name
- NCT03312621
- Testing
- Health Care Transition Care Coordination
- Volunteers
- 209 people
- Sponsor
- Lisa Tuchman
Kidney Transplantation, Medication Adherence
Video Education and Behaviour Contract to Optimize Adherence in Renal Transplants
This study aims to test the effectiveness of an electronic-based video intervention and behavioral contract on improving medication adherence among kidney transplant recipients.
- Trial name
- VECTOR (NCT03540121)
- Testing
- Video education + adherence contract
- Where
- 3 sites in United States, Canada
- Volunteers
- 173 people
- Sponsor
- University of Saskatchewan
Caring Efficacy
The Power of Self-efficacy-based Interventions in Fostering Caring Self-efficacy and Overcoming Job-related Stress and Perceived Stigma Among Psychiatric Nurses
People with high self-efficacy set goals to challenge and improve their task achievement rate; however, people with low self-efficacy tend to have fluctuation in their ways of thinking, which results in dampened spirits.
- Trial name
- NCT05952414
- Testing
- self-efficacy-based interventions
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
PARKINSON DISEASE (Disorder)
Multicontext Approach for Cognitive Function in Parkinson Disease
Mild cognitive decline is common in early Parkinson disease (PD) and is associated with disability, reduced quality of life (QOL), and increased risk for dementia.
- Trial name
- MC4PD R01 (NCT07190404)
- Testing
- A metacognitive strategy for cognitive rehabilitation called the Multicontext Approach., Cognitive (Process) Training, MC Approach Booster Session
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Washington University School of Medicine
Mental Health Issue
Implementation Science to Improve School Ethos for Mental Health
The objective of the study is to identify the challenges and opportunities existing within the school ethos in implementing evidence-based interventions to improve youth mental health and to identify the most appropriate…
- Trial name
- NCT06488404
- Where
- India
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Pain
Physical Activity and Acceptance and Commitment Therapy as Treatment for Long Term Pain
Only to a limited extent has been compared the effectiveness of physical exercise and psychological interventions in subjects with chronic pain.
- Trial name
- FACTA (NCT02399644)
- Testing
- ACT, Physical activity
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Linkoeping University
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