Clinical trials: Intestine
Obesity, Food Preferences
How Altered Gut-Brain-Axis Influences Food Choices: Part 1
Obesity is currently one of the most substantial health burdens. Due to the production of marked and sustained weight loss, bariatric surgery is an increasingly used therapeutic modality to combat obesity and its comorbidities.
- Trial name
- BrainFood (NCT04813003)
- Testing
- Functional Brain Imaging and neurobehavioural tasks
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lia Bally
Focus of Study; Impact of MSPrebiotic on Gastrointestinal Microbiota
Effects of MSPrebiotic on Gut Health in the Elderly
The purpose of this clinical trial is to study the effects of potato resistant starch on the microbiota (microorganisms or bacteria) and short chain fatty acids levels of the gut.
- Trial name
- NCT01977183
- Testing
- MSPrebiotic
- Where
- 2 sites in Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- St. Boniface Hospital
Diabetes Mellitus, Gut Microbiota
Correlation Between Gut Microbiota and Pancreatic Β-Cell Function in Diabetic Patients
The gut microbiota plays a crucial role in digestion, metabolism, nutrition, and immune regulation in the human body. In recent years, numerous studies have indicated that the gut microbiota and its metabolites are closely…
- Trial name
- NCT06645223
- Testing
- No Interventions
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Dyslipidaemia, Insulin Resistance
Regulation of Intestinal and Hepatic Lipoprotein Secretion by Resveratrol
Resveratrol, an ingredient of red wine and available in Canada in highly purified form as an over-the-counter health supplement, has been shown to have a number of health benefits.
- Trial name
- NCT01451918
- Testing
- Resveratrol
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Change in Fasting Plasma LDL-cholesterol Concentration After the Consumption of Quinoa
Effects of Quinoa Consumption on Markers of Cardiovascular Risk and Gastrointestinal Health
Quinoa is possible alternative to wheat, corn and rice due to its high nutritional value and possible properties against cardiovascular diseases and for improving gut health.
- Trial name
- NCT03036618
- Testing
- Quinoa, Wheat
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Colitis, Ulcerative
An Analysis of the Relationship Between the Genetic Polymorphisms of Plasminogen Activator Inhibitor-1 and Ulcerative Colitis in Chinese Patients
From January 2019 to February 2025, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT06961435
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Warts, Genital, Neoplasms, Anal
Efficacy, Immunogenicity, and Safety Study of V503 (9-valent Human Papillomavirus [9vHPV] Vaccine) in Japanese Males (V503-064)
The purposes of this phase 3, double-blind, placebo-controlled clinical study are to evaluate the efficacy of V503 in preventing human papillomavirus (HPV)-related anogenital persistent infection, and to evaluate the…
- Trial name
- NCT04635423
- Testing
- V503
- Where
- 22 sites in Japan
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Hirschsprung's Disease Associated Enterocolitis
Neuro-Immune Interactions in the Gut
Hirschsprung's disease (HD) is diagnosed shortly after birth and is characterized by the presence of megacolon. HD is caused when ganglion cells of the enteric nervous system (ENS) in the wall of the large intestine do not…
- Trial name
- NIG (NCT03617640)
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital Basel
Healthy, Colitis, Ulcerative
A Study of JNJ-66525433 in Healthy Participants and Participants With Ulcerative Colitis
The purpose of this study is to evaluate safety and tolerability of JNJ 66525433 compared with placebo after administration of: 1) single ascending oral doses of JNJ 66525433 administered to healthy participants (Part 1), 2)…
- Trial name
- NCT04457960
- Testing
- JNJ-66525433
- Where
- Germany
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Escherichia Coli; Infection, Intestinal
Study of the Ecological and Evolutionary Dynamics of Escherichia Coli in the Digestive Commensal Flora
Escherichia coli (E. coli) poses a major public health problem. E. coli is not only a commensal of the digestive tract but also a major opportunistic pathogen, first cause of urinary tract infections, first cause of bacteremia.
- Trial name
- EVE (NCT05153824)
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Standardizing Method and Development of Normal Values to Measure Human Small Intestinal and Colonic Permeability
To develop a test to measure small bowel and colonic permeability.
- Trial name
- NCT04262310
- Testing
- Small Bowel and Colonic Permeability Test
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obesity, Type 2 Diabetes
Gut Hormones and Roux en Y Gastric Bypass
The purpose of this study is to assess whether the changes in gut hormones seen following Roux en Y Gastric Bypass surgery are responsible for some of the beneficial effects seen post-operatively.
- Trial name
- NCT01945840
- Testing
- Roux en Y Gastric Bypass Surgery, Gut hormone infusion, Very low calorie diet
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Overweight, Obesity
The Effects of Quinoa and Buckwheat on Weight Management and Gut Microbiome
This study aims to compare the effects of quinoa, buckwheat, rice, and bulgur consumption on dietary intake, anthropometric measurements, glycemic response, lipid profile, inflammatory markers, blood pressure, and intestinal…
- Trial name
- NCT07513610
- Testing
- quinoa, Buckwheat, Rice
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gastrointestinal Symptoms
Impact of Dietary Fibre Supplementation on Gut Symptoms in Healthy Participants
Fibres found in food are mainly carbohydrates that are not broken down or absorbed during human digestion but instead pass to the colon to be fermented by microbes.
- Trial name
- KiVa (NCT07587424)
- Testing
- cellulose, Oat fibre, Rye fibre
- Where
- Finland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Colorectal Cancer
Health Message Framing to Improve Uptake of Bowel Cancer Screening
The objective of this research is to investigate whether a text message (SMS message) prompting participation in the UK national bowel cancer screening programme improves uptake for those who have not responded to the test.
- Trial name
- NCT03487523
- Testing
- Text Message
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- National Heatlh Service Ayrshire and Arran
Gastric Cancer, Colorectal Cancer
Individually Tailored Strategies for the Precision Prevention of Gastric Cancer and Colorectal Cancer in the Community
Gastric cancer is a global health threat. Helicobacter pylori is now recognized as the main risk factor that initiates this process; hence, H.
- Trial name
- NCT03793335
- Where
- Taiwan
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Metabolism
Choline Source, Gut Microbiota and Trimethylamine-N-oxide Response
The purpose of this research is to determine the production of trimethylamine-N-oxide (TMAO) from different forms of choline and whether this response is modified by the gut microbiota composition.
- Trial name
- NCT04255368
- Testing
- Water-soluble choline, Fat-soluble choline, No choline control
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Utah State University
Colorectal Cancer
Colon Cancer Prevention Study
The goal of this research study is to design messages which can help people learn more about how to prevent colon cancer. Eligible participants will be asked to review a series of short cancer prevention messages and share their…
- Trial name
- NCT00924690
- Testing
- Behavioral Messages, Generic Messages
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Micronutrient Deficiencies
Effect of Sprinkles With and w/o Fe on Zn Absorption in Kenyan Toddlers
The investigators propose to study the effects of increased iron intake by home fortification of complementary foods on the gastrointestinal microbial development, inflammatory responses, and zinc (Zn) absorption.
- Trial name
- NCT02101723
- Testing
- MNP + Zn/Fe, MNP + Zn
- Where
- 2 sites in United States, Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiometabolic Risk, Weight Loss
Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora
The purpose of this study is to estimate the effects of caloric restriction and exercise on body weight, cardiovascular metabolic markers, immune function, and intestinal flora among college students, as well as the underlying…
- Conditions
- Cardiometabolic Risk, Weight Loss, Immune System, Intestinal Microbiome
- Trial name
- NCT04275440
- Testing
- Exercise, Caloric restriction
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
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