Clinical trials: Intracranial Neoplasms
Adult Intracranial Neoplasm, Vascular: Intracranial
Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions
The purpose of this study is to evaluate the effectiveness of using Fluorescein Sodium and the Yellow 560 microscope to aid in treatment of intracranial tumors and vascular lesions.
- Trial name
- Fluorescein (NCT02028325)
- Testing
- Fluorescein Sodium
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Indiana University
Brain Edema, TBI (Traumatic Brain Injury)
Dynamic Decompressive Craniotomy
Prospective observational study on patients undergoing decompressive craniotomy
- Conditions
- Brain Edema, TBI (Traumatic Brain Injury), Stroke, Acute, Cerebral Hemorrhage
- Trial name
- NCT05051488
- Testing
- Dynamic craniotomy
- Volunteers
- 20 people
- Sponsor
- Rohit Khanna, MD
Brain Metastases, Adult, Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial
This pilot pragmatic trial evaluates the feasibility of avoiding radiation therapy in patients with brain metastases who demonstrate an intracranial response to systemic therapy-including immunotherapy, targeted therapy, and/or…
- Trial name
- ACTION-Brain (NCT06974370)
- Testing
- Active Surveillance
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Vermont Medical Center
Brain Tumor, Intracranial Pressure
Comparison of Two Doses of Mannitol on Brain Relaxation During Supratentorial Craniotomy
Neuroanesthesia for supratentorial surgery involves a thorough understanding of the physiopathology of intracranial pressure, cerebral homeostasis and regulation of cerebral perfusion pressure as well as the effects of anesthesia…
- Trial name
- NCT01048684
- Testing
- Mannitol
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma
Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma
This phase I trial is studying the side effects and best dose of bevacizumab and cediranib maleate in treating patients with metastatic or unresectable solid tumor, lymphoma, intracranial glioblastoma, gliosarcoma or anaplastic…
- Conditions
- Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma
- Trial name
- NCT00458731
- Testing
- bevacizumab, cediranib maleate
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Alzheimer Disease, Mild Dementia
Improving Everyday Task Performance Through Repeated Practice in Virtual Reality.
There are very few effective interventions that promote functional independence in people with Alzheimer's disease (AD) and related dementias.
- Conditions
- Alzheimer Disease, Mild Dementia, Mild Cognitive Impairment, Dementia
- Trial name
- VKI (NCT04315337)
- Testing
- Virtual Kitchen Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Temple University
Osmotherapy, Intracranial Pressure
Comparison of 20% Mannitol and 3% Hypertonic Saline for Cerebral Relaxation During Elective Supratentorial Craniotomies
Mannitol 20% has long been used to treat elevated intracranial hypertension in trauma and intensive care settings. More recent data indicate that hypertonic saline may be as effective or more effective than mannitol for this…
- Trial name
- NCT01745081
- Testing
- 20% mannitol bolus administration, Hypertonic saline 3% bolus administration
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Université de Sherbrooke
Intracranial Tumors, Glioblastoma
A Pilot Study to Evaluate PBR PET in Brain Tumor Patients Treated With Chemoradiation or Immunotherapy
This research study is studying the changes in primary and metastatic brain tumor inflammation using positron emission tomography (PET) imaging using a radioactive substance called [11C] PBR28a, which is also known as peripheral…
- Conditions
- Intracranial Tumors, Glioblastoma, Melanoma
- Trial name
- NCT02431572
- Testing
- PBR PET, Cancer Immunotherapy, Radiation and chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Intracerebral Hemorrhage, Subarachnoid Hemorrhage
Al Prediction of Sarcopenia Risk in Neurocritical ICU Patients
This prospective observational study aims to evaluate sarcopenia in intensive care patients with intracranial pathologies using ultrasound and to compare the predictive performance of different artificial intelligence models.
- Conditions
- Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Subdural Hematoma, Epidural Hematoma
- Trial name
- NCT07712198
- Testing
- Prospective Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Brain Injuries, Subarachnoid Hemorrhage
An Evaluation of a Non-invasive Brain Monitor
HS-1000 device, a proprietary new non-invasive brain monitor, is expected to safely and accurately monitor physiological signs of the brain with minimal discomfort to patients, providing information about normal or abnormal…
- Conditions
- Brain Injuries, Subarachnoid Hemorrhage, Vasospasm, Intracranial, Hydrocephalus
- Trial name
- NCT02775136
- Testing
- HS-1000 recording
- Where
- 4 sites in Germany
- Volunteers
- 160 people
- Sponsor
- HeadSense Medical
Brain Metastases, Adult
Intrafractional Head Movement During Radiosurgery
This study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head movements.
- Trial name
- NCT03896555
- Testing
- ExacTrac position verification
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University Innsbruck
Tumor, Cerebral Ventricle, Tumor, Cerebellar
Post Market Clinical Follow-Up Study on the Performance and Safety of Lyoplant®
Retrospective, single center, single arm PMCF study on the performance and safety of Lyoplant® used for the replacement and extension of connective tissue structures in neurosurgery.
- Conditions
- Tumor, Cerebral Ventricle, Tumor, Cerebellar, Aneurysm Cerebral, Trauma, Brain
- Trial name
- LYOPLACE (NCT05441618)
- Testing
- Lyoplant®
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Aesculap AG
Intracranial Meningioma
Multisession Radiosurgery in Large Meningiomas
This is a prospective observational trial consisting of robotic multisession radiosurgery (CyberKnife ®) for large and medium size and/or located at critical site benign intracranial meningiomas.
- Trial name
- MuRaLM (NCT02974127)
- Testing
- Radiotherapy
- Where
- Italy
- Volunteers
- 178 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Metastatic Melanoma
Whole Brain Radiotherapy Following Local Treatment of Intracranial Metastases of Melanoma
People with brain metastases from melanoma are offered different treatment options after local treatment of their brain metastases via surgery or stereotactic irradiation.
- Trial name
- WBRTMel (NCT01503827)
- Testing
- WBRT
- Where
- 23 sites in Australia, Norway and 1 more
- Volunteers
- 220 people
- Sponsor
- Melanoma and Skin Cancer Trials Limited
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Sodium Lactate, Intracranial Hypertension
Sodium Lactate and Brain Relaxation (LSD)
Resection surgery of brain tumors by craniotomy requires efficient brain relaxation intraoperatively in order to avoid injuries caused by the brain retractors (such as ischemic-reperfusion and cerebral oedema).
- Conditions
- Sodium Lactate, Intracranial Hypertension, Brain Relaxation
- Trial name
- LSD (NCT04488874)
- Testing
- Sodium Lactate, Mannitol 20% Infusion
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Brain and Central Nervous System Tumors
Radiation Therapy and Combination Chemotherapy in Treating Young Patients With Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Ependymoma
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00303810
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- Germany
- Volunteers
- 567 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf