Clinical trials: Intraoperative
Post-operative Infections
Reduction in IV Associated Contamination
The purpose of this study is to investigate whether implementing a novel syringe and IV stopcock cap system impregnated with alcohol will reduce IV catheter bacterial contamination and infections in patients.
- Trial name
- NCT01426217
- Testing
- Passive Bundle PSI (Problem Solving Innovations) Medical HubScrub, PSI Medical DocIt
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
General Anesthesia, Intraoperative Awareness
Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia
This prospective observational study will evaluate neuro-mimic indicators of anesthesia depth, including eyelid reflex, eyeball movements, and pupil responses, in patients undergoing elective surgery under general anesthesia.
- Conditions
- General Anesthesia, Intraoperative Awareness, Eye Movements
- Trial name
- NCT07199049
- Testing
- Neuro-Mimic Observation Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Anterior Cruciate Ligament Injuries
Infection Rates Between Using of Vancomycin Versus Gentamycin in Primary ACLR
The purpose of the study is to compare the efficacy of Vancomycin versus Gentamycin , in reducing infection rates following Anterior Cruciate Ligament Reconstruction .
- Trial name
- ACLR (NCT06050785)
- Testing
- Vancomycin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Assiut University
Work-related Injury, Physical Injury
Intraoperative Exercises & Musculoskeletal Pain in Gynecologic Surgeons
The goal of this study is to evaluate the effect of intraoperative microbreaks and exercises on gynecologic surgeon body discomfort by conducting a randomized trial.
- Trial name
- GynIEx (NCT05761288)
- Testing
- Intraoperative microbreaks and exercises
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Postoperative Atrial Fibrillation
The Effect of Intra Operative Dexmedetomidine in Prevention of Early Postoperative Atrial Fibrillation
The incidence of atrial fibrillation (AF) after lung resection varies between 12% and 30% after lobectomy and 23%-67% after pneumonectomy. The average time of onset of AF after lung resection is 2-3 days.
- Trial name
- NCT05320705
- Testing
- Intra Operative Dexmedetomidine
- Where
- Egypt
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Macular Edema, Cystoid, Vision Disorders
Intraoperative Dexamethasone Implant Improves Outcome of Cataract Surgery With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant, (Ozurdex®) in improving outcome of cataract surgery in patients with diabetic macular edema.
- Conditions
- Macular Edema, Cystoid, Vision Disorders, Diabetic Macular Edema, Cystoid Macular Edema Following Cataract Surgery
- Trial name
- NCT01546402
- Testing
- Dexamethasone Drug delivery system (Ozurdex), Cataract surgery
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Brain Neoplasms
IORT After Surgical Resection of Brain Metastases
To evaluate the feasibility and efficacy of the Intraoperative Radiation Therapy (IORT) after the resection of a brain metastases to reduce the incidence of local relapse
- Trial name
- IORT_BRAINM1 (NCT05084092)
- Testing
- Intraoperative Radiotherapy (IORT), Brain surgery
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Intraoperative Awareness, Anesthesia, General
Subconscious Effects of Intraoperative Speech: Health Professionals' Perceptions
This observational, questionnaire-based study aims to evaluate health professionals' perceptions regarding the potential subconscious effects of intraoperative conversations on patients.
- Conditions
- Intraoperative Awareness, Anesthesia, General, Consciousness
- Trial name
- NCT07396727
- Testing
- Questionnaire / Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists
Effect of Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RA) on Gastric Emptying
This study aims to assess the effect of using Glucagon-like peptide-1 receptor agonists (GLP-1) receptor agonists on gastric emptying on surgical patients and whether specific guidelines need to be established for these patients.
- Conditions
- Gastric Emptying, Glucagon-Like Peptide-1 Receptor Agonists, Intermittent Fasting, Intraoperative Complication Due to Anesthesia
- Trial name
- NCT07140289
- Testing
- Ultrasound of gastric contents
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wael Saasouh, MD
Myomectomy; Surgical Blood Loss
Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time.
- Trial name
- NCT03064568
- Testing
- Misoprostol 200Mcg Tab
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Osteoarthritis, Knee
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels.
- Trial name
- NCT02570503
- Testing
- Ropivacaine, Ketorolac, Clonidine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Retinal Diseases, Fuchs Endothelial Dystrophy
DISCOVER Study: Microscope-integrated Intraoperative OCT Study
Optical coherence tomography (OCT )provides high resolution information regarding the anatomic structure of the tissues of the eye in a cross-sectional and 3 dimensional view.
- Conditions
- Retinal Diseases, Fuchs Endothelial Dystrophy, Macular Hole, Epiretinal Membrane
- Trial name
- DISCOVER (NCT02423213)
- Where
- United States
- Volunteers
- 2,911 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Erector Spinae Plane Block
Effectiveness of Bilateral Ultrasound-Guided Erector Spinae Plane Block
The proposed mechanism of action of the ESPB is via blockade of the dorsal and ventral rami of the spinal nerves and sympathetic nerve fibers.
- Trial name
- NCT04110210
- Testing
- Bilateral Ultrasound-Guided Erector Spinae Plane Block, Morphine Consumption
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Burst Suppression, General Anesthesia
Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG
Burst suppression describes a specific EEG pattern that can generally indicate a too deep general anesthesia. The pathophysiology of anesthetic-induced Burst Suppression may be distinctly different from the pathophysiology of…
- Conditions
- Burst Suppression, General Anesthesia, Electroencephalogram
- Trial name
- NCT05508386
- Testing
- MATLAB-based interface, showing 50 EEG traces, classification of the EEG-pattern as Burst Suppression possible, yes, no.
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Intraoperative Complications, Intraoperative Hypotension
The Use of Surgical Pleth Index in Guiding Anesthesia in Gastroenterological Surgery
Surgical Pleth Index (SPI) is an intraoperative monitor aimed into detection of nociception and guidance of intraoperative opioid administration.
- Conditions
- Intraoperative Complications, Intraoperative Hypotension, Intraoperative Hypertension
- Trial name
- NCT04519203
- Testing
- SPI, Standard
- Where
- Finland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Sleep Apnea, Obstructive Sleep Apnea
Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep Apnea
The aim of this study is to substantially reduce overall postoperative morbidity and mortality associated with obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Postoperative Complications
- Trial name
- NCT03109418
- Testing
- Ketamine, Control
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cataract Surgery
Comparison of Pre-operative Measurements With Intraoperative Aberrometry in Predicting Correction for Low Toric Lens Correction in Cataract Surgery
Examination of the accuracy of toric predictive power in patients with 1.5 diopters of astigmatism or less.
- Trial name
- NCT04247152
- Testing
- Intraoperative Aberrometry vs preoperative biometry
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Postoperative Pain
Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy
A randomized controlled trial evaluating the efficacy and safety of single-shot intraoperative methadone for postoperative pain in patients undergoing tonsillectomy. Fentanyl is used as an active comparator
- Trial name
- METATONS (NCT05445856)
- Testing
- Methadone, Fentanyl
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Perioperative Pain, Perioperative Anxiety
The Use of Virtual Reality to Reduce Anxiety and Pain in Perioperative Settings
We will investigate whether the use of Virtual Reality (VR) preoperatively and intraoperatively can help treat pain and anxiety, as measured by patient feedback, vital signs trends, and the amounts of anesthetics, pain…
- Trial name
- NCT03744845
- Testing
- Virtual Reality Distraction
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco