Clinical trials: Intraoperative Blood Loss
Arthropathy of Hip, Arthropathy of Knee
Tranexamic Acid Dosing for Total Joint Arthroplasty
The purpose of this study is to determine the effect of increasing doses of tranexamic acid (TXA) on limiting blood loss during total knee and total hip arthroplasty as defined by a change in hemoglobin from pre-operative…
- Trial name
- NCT02584725
- Testing
- Tranexamic Acid
- Volunteers
- 84 people
- Sponsor
- Columbia University
Surgery, Surgical Blood Loss
Association of Anemia With Hospital Costs in Elective Colorectal Surgery
The objective is to measure the adjusted association between preoperative anemia and total hospital costs. We hypothesize that patients with anemia before surgery will have higher hospitalization costs than people without anemia.
- Conditions
- Surgery, Surgical Blood Loss, Anemia, Colon Cancer
- Trial name
- NCT03476707
- Testing
- Anemia
- Volunteers
- 851 people
- Sponsor
- Ottawa Hospital Research Institute
Hemorrhage, Surgical, Blood Loss, Surgical
Safe and Timely Antithrombotic Removal - Ticagrelor (STAR-T)
Prospective, multi-center, double-blind, randomized pivotal trial to evaluate the safety and effectiveness of the DrugSorb-Antithrombotic Removal (ATR) system for intraoperative removal of ticagrelor in patients undergoing urgent…
- Conditions
- Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
- Trial name
- STAR-T (NCT04976530)
- Testing
- DrugSorb-ATR system
- Where
- 29 sites in United States, Canada
- Volunteers
- 140 people
- Sponsor
- CytoSorbents, Inc
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Coronary Artery Disease, Coronary Artery Bypass
Impact of Fluid Restriction Policy in Reducing the Use of Red Cells in Cardiac Surgery
The investigators' hypothesis is that restriction of circulating fluids in comparison to a liberal fluid administration policy would lead to a reduction of allogenic red blood cells exposure in patients undergoing cardiopulmonary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Erythrocyte Transfusion
- Trial name
- NCT00600704
- Testing
- Fluid Restriction Policy, Free fluid infusion
- Where
- Greece
- Volunteers
- 192 people
- Sponsor
- Larissa University Hospital
Intraoperative Bleeding, Hemorrhage, Surgical
GATT-Patch Versus TachoSil in Liver Surgery
This is a pre-market, prospective, randomized (2:1), multicenter, multi-national pivotal clinical investigation. The purpose of this investigation is to determine the clinical safety and performance of GATT-Patch as compared with…
- Conditions
- Intraoperative Bleeding, Hemorrhage, Surgical, Liver Diseases
- Trial name
- NCT05385952
- Testing
- GATT-Patch (currently named ETHIZIA), TachoSil
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- GATT Technologies BV
Blood Loss, Surgical
Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial
The main purpose of this study is to compare blood loss at the time of laparoscopic or robotically-assisted laparoscopic myomectomy when using different amounts of dilute vasopressin solution.
- Trial name
- NCT01393704
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Brigham and Women's Hospital
Surgical Bleeding
Topical Raplixa for Surgical Bleeding in Children
The purpose of the study is to determine if Raplixa plus Gelfoam is better than Gelfoam alone in stopping mild to moderate bleeding in children having surgery.
- Trial name
- NCT02117349
- Testing
- Raplixa, Gelfoam, Rescue treatment
- Where
- 13 sites in United States
- Volunteers
- 55 people
- Sponsor
- Mallinckrodt
Bleeding Active
Effectiveness and Safety of CELSTAT for Hemostasis in Intraoperative Tissue Bleeding
The study is to evaluate the effectiveness and safety of CELSTAT vs active control.
- Trial name
- CELSTAT (NCT02640235)
- Testing
- CELSTAT, Surgicel Original
- Where
- 25 sites in United States, Czechia and 2 more
- Volunteers
- 260 people
- Sponsor
- Baxter Healthcare Corporation
Blood Loss, Surgical
Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
To examine in Arista hemostatic powder results in less post-total knee arthroplasty blood loss, hematoma formation, and improved range of motion when compared to patients who did not receive the product.
- Trial name
- NCT05522153
- Testing
- Arista
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Hemorrhage
The SURGICEL® Powder Mild or Moderate Parenchymal or Soft Tissue Intraoperative Bleeding (China Study)
This is a single blind, randomized, prospective study comparing SURGICEL Powder with SURGICEL Original (control arm) as an adjunct to achieve hemostasis in the control of capillary, venous, and small arterial hemorrhage when…
- Trial name
- NCT03783039
- Testing
- SURGICEL Powder, SURGICEL Original
- Where
- 6 sites in China
- Volunteers
- 234 people
- Sponsor
- Ethicon, LLC
Myomectomy; Surgical Blood Loss
Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time.
- Trial name
- NCT03064568
- Testing
- Misoprostol 200Mcg Tab
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Blood Loss, Surgical
Prospective, Multicenter, Multidisciplinary, Controlled Clinical Investigation Evaluating the Safety and Efficacy of PerClot® Polysaccharide Hemostatic System
This is a prospective, multicenter, multidisciplinary, controlled clinical investigation evaluating the safety and efficacy of PerClot in achieving intraoperative hemostasis compared to a similar marketed hemostatic device.
- Trial name
- CLOT (NCT02359994)
- Testing
- PerClot Polysaccharide Hemostatic System, Arista AH
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Artivion Inc.
Intraoperative Staple Line Bleeding as Measured by the Provided Bleeding Severity Scale
Endostapler Hemostasis Study
The goal of this prospective, multi-center, post-market study is to measure AEON™ Endostapler performance with the EASY/THICK MODE feature for laparoscopic bariatric surgery against the Echelon Flex™ Powered Stapler system from…
- Trial name
- NCT04149925
- Testing
- AEON Endostapler, Echelon Flex Powered Stapler
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lexington Medical Inc.
Rotator Cuff Tears, Hemorrhage, Surgical
Effect of Intravenous Tranexamic Acid on Visual Clarity During Shoulder Arthroscopy in the Beach Chair Position
Shoulder arthroscopy offers numerous advantages and has led to a continuous increase in procedural complexity. Adequate intraoperative visual clarity is essential for successful performance of the procedure and is primarily…
- Conditions
- Rotator Cuff Tears, Hemorrhage, Surgical, Shoulder Injuries
- Trial name
- NCT05397652
- Testing
- Tranexamic Acid Injectable Product
- Where
- Croatia
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Nikola Matejcic
Proliferative Diabetic Retinopathy, Vitreous Hemorrhage
Pre- and Intra-operative Intravitreal Bevacizumab Injection in Diabetic Vitrectomy
The purpose of this study is to determine the effect of pre- and intra-operative bevacizumab injection on postoperative vitreous hemorrhage after diabetic vitrectomy.
- Trial name
- IBDV (NCT00745498)
- Testing
- Bevacizumab
- Where
- South Korea
- Volunteers
- 126 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis, Intraoperative Bleeding
Use of a Novel Fibrin Sealant in Total Knee Arthroplasty
Applying a fibrin spray, after knee device implantation, will help in reducing patient blood loss and decrease the drop in both hemoglobin and hematocrit levels.
- Trial name
- NCT01656759
- Testing
- Evicel Fibrin Spray
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Intraoperative Bleeding
Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery
In endoscopic sinus surgery a clear surgical field of view is a very important aspect for good surgical outcome. This study is to evaluate the preoperative preparation to acquire best surgical field of view by comparing between…
- Trial name
- NCT05867342
- Testing
- Epinephrin, 1% lidocaine with epinephrin 1:100,000, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Intraoperative Bleeding
Adjunctive Application of BioFoam Surgical Matrix in Liver Surgery
This is a prospective, multicenter, randomized, controlled investigation. Subjects in which bleeding from the exposed parenchymal surface is observed intraoperatively following the ligature of vessels visible with the unaided eye…
- Trial name
- BARRIER (NCT01458561)
- Testing
- BioFoam Surgical Matrix, Gelfoam Plus
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- CryoLife, Inc.
Blood Loss, Surgical, Second Trimester Abortion
MisOpRostol Effect on Second Trimester Abortion Blood Loss
Although serious complications from second trimester abortion are rare hemorrhage is the most common cause of procedural abortion related morbidity and mortality.
- Trial name
- MORESTABL (NCT06078501)
- Testing
- Misoprostol 400mcg buccal
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Stanford University